Colon irrigation causes lymphocyte movement from gut-associated lymphatic tissues to peripheral blood.
Biomed Res. 2009 Oct;30(5):311-4. PMID: 19887728
It is well established that the intestine is an important site responsible for the local immune system. It is speculated that people suffering from constipation and carrying fecal residues in the intestine may have a decreased function of this immune system. In this study, colon irrigation, which is cleansing of the colon using a simple hydrotherapy instrument, was performed in 10 subjects with or without the disease. The number of leukocytes and their demarcation were then evaluated. The number and ratio of lymphocytes increased significantly after irrigation. This result suggested that colon irrigation might induce lymphocyte transmigration from gut-associated lymphatic tissues into the circulation, which may improve colon and immune system function.
Article Published Date : Oct 01, 2009
Mechanical colon cleansing for screening colonoscopy: a randomized controlled trial.
J Dig Dis. 2017 Nov 21;:
Authors: Ayub K, Ketwaroo G, Abudayyeh S, Ibrahim A, Cole RA, Brumfield-Brown R, Qureshi WA, Rabeneck L, Graham DY
AIMS: Effective screening colonoscopy depends on the quality of colon preparation. To compare pulsed irrigation evacuation (PIE), polyethylene glycol (PEG) and sodium phosphate colon preps.
METHODS: Outpatients at a VA hospital were randomized using sealed envelopes. Preparations consisted of: 4 liters Golytely; 90 mL of Fleet sodium phosphate with 4-6 glasses water b.i.d., and 296 mL of Mg citrate in the evening with PIE prior to colonoscopy. Colon cleansing was assessed blindly using a 5-point scale: 0 = very poor to 4 = excellent.
RESULTS: 391 patients participated (PEG = 129, sodium phosphate = 127, PIE = 135); mean age: 62 years, 75% men. PIE and sodium phosphate were superior to PEG: median cleansing = 4 (excellent) vs. 3 with PEG (p <0.01). Inadequate preps were more common with PEG than PIE (18% vs. 5%) (p <0.01). Side effects including: vomiting: 37% with the sodium phosphate vs. 5% with PEG and 2% with PIE (p<0.01). The 3 preps were judged as intolerable in <5%.
CONCLUSIONS: PIE and sodium phosphate were superior to PEG for colon preparations. PIE would be the preferred preparation for those at high risk for unsatisfactory preparations or with unsatisfactory traditional preparations.
PMID: 29160622 [PubMed - as supplied by publisher]