Abstract Title: Whole-body vibration training increases physical measures and quality of life without altering inflammatory-oxidative biomarkers in patients with moderate COPD. Abstract Source: J Appl Physiol (1985). 2018 May 3. Epub 2018 May 3. PMID: 29722619 Abstract Author(s): Camila Danielle Cunha Neves, Ana Cristina Rodrigues Lacerda, Vanessa Kelly Silva Lage, Aline Alves Soares, Maria Gabriela Abreu Chaves, Liliana Pereira Lima, Thyago José Silva, Érica Leandro Marciano Vieira, Antônio Lúcio Teixeira, Hércules Ribeiro Leite, Mariana Aguiar Matos, Vanessa Amaral Mendonça Article Affiliation: Camila Danielle Cunha Neves Abstract: The whole-body vibration training (WBVT) has been identified as an alternative intervention to improve exercise capacity and quality of life of patients with Chronic Obstructive Pulmonary Disease (COPD). However, the effect of WBVT on inflammatory-oxidative biomarkers remains unknown. The aim of this trial was to investigate the effects of WBVT on quality of life and physical and inflammatory-oxidative parameters in patients with COPD. Twenty patients were equally divided into: 1) intervention group (IG) that performed the WBVT, and 2) control group (CG) that did not receive any intervention. Intervention consisted in performing static squatting on vibrating platform, in six series of 30 seconds, 3 d.wk, for 12 weeks. Patients were evaluated for: plasma levels of IL-6, IL-8, IFN-ɣ, soluble receptors of TNF-α; white cells count; plasma levels of oxidant and antioxidant markers; the 6-minute walking distance (6MWD); peak oxygen uptake (VOpeak); handgrip strength; quality of life; timed 5-chair sit-to-stand (5STS) and timed get-up and go test (TUG). After WBVT, patients from IG showed significant increase in the 6MWD, VOpeak and handgrip strength (p<0.05). Furthermore, patients from IG reached minimal clinically important difference regarding quality of life. No significant differences were found in 5STS, TUG, inflammatory-oxidative biomarkers and white cells count in the IG. CG did not show significant improvement in all assessments (p>0.05). Taking together, our results demonstrated that the WBVT induced clinically significant benefits regarding exercise capacity, muscle strength and quality of life in patients with COPD, that were not related to inflammatory-oxidative biomarkers changes. Article Published Date : May 02, 2018

Abstract Title: Whole body vibration on people with sequelae of polio. Abstract Source: Physiother Theory Pract. 2018 Mar 29:1-11. Epub 2018 Mar 29. PMID: 29596010 Abstract Author(s): Carolyn P Da Silva, C Lauren Szot, Natasha deSa Article Affiliation: Carolyn P Da Silva Abstract: PURPOSE: The purpose was to explore the feasibility of whole body vibration (WBV) on polio survivors with/without post-polio syndrome (PPS) by studying its effects on walking speed (10-m walk test), endurance (2-min walk test), pain severity/interference (Brief Pain Inventory [BPI]), sleep quality (Pittsburg Sleep Quality Index), fatigue (Fatigue Severity Scale), leg strength (manual muscle testing and hand-held dynamometry), and muscle cramping (written logs) METHODS: Fifteen individuals completed the study, participating in eight sessions in two 4-week blocks. Participants started with ten 1-min vibration bouts/session, increasing to 20 min. Low (amplitude 4.53 mm, g force 2.21) and higher (amplitude 8.82 mm, g force 2.76) intensity blocked intervention occurred in random order crossover design. Blinded testing ensued before/after intervention blocks and at follow-up. RESULTS: No study-related adverse events occurred. Participants starting first with higher intensity intervention improved in walking speed (p = 0.017). BPI pain severity significantly improved (p = 0.049) after higher intensity intervention. No significant changes were found after low intensity vibration or in other outcome measures. CONCLUSIONS: WBV appears to be a safe exercise for this population. Long-term use in polio survivors needs to be researched, particularly in reducing barriers to participation to promote the physical aspects of health. Article Published Date : Mar 28, 2018

Abstract Title: Inflammatory biomarkers responses after acute whole body vibration in fibromyalgia. Abstract Source: Braz J Med Biol Res. 2018 Mar 1 ;51(4):e6775. Epub 2018 Mar 1. PMID: 29513791 Abstract Author(s): V G C Ribeiro, V A Mendonça, A L C Souza, S F Fonseca, A C R Camargos, V K S Lage, C D C Neves, J M Santos, L A C Teixeira, E L M Vieira, A L Teixeira Junior, B Mezêncio, J S C Fernandes, H R Leite, J R Poortmans, A C R Lacerda Article Affiliation: V G C Ribeiro Abstract: The aims of this study were 1) to characterize the intensity of the vibration stimulation in women diagnosed with fibromyalgia (FM) compared to a control group of healthy women (HW) matched by age and anthropometric parameters, and 2) to investigate the effect of a single session of whole body vibration (WBV) on inflammatory responses. Levels of adipokines, soluble tumor necrosis factor receptors (sTNFr1, sTNFr2), and brain-derived neurotrophic factor (BDNF) were determined by enzyme-linked immunosorbent assay. Oxygen consumption (VO2) was estimated by a portable gas analysis system, heart rate (HR) was measured using a HR monitor, and perceived exertion (RPE) was evaluated using the Borg scale of perceived exertion. Acutely mild WBV increased VO2 and HR similarly in both groups. There was an interaction (disease vs vibration) in RPE (P=0.0078), showing a higher RPE in FM compared to HW at rest, which further increased in FM after acute WBV, whereas it remained unchanged in HW. In addition, there was an interaction (disease vs vibration) in plasma levels of adiponectin (P=0.0001), sTNFR1 (P=0.000001), sTNFR2 (P=0.0052), leptin (P=0.0007), resistin (P=0.0166), and BDNF (P=0.0179). In conclusion, a single acute session of mild and short WBV can improve the inflammatory status in patients with FM, reaching values close to those of matched HW at their basal status. The neuroendocrine mechanism seems to be an exercise-induced modulation towards greater adaptation to stress response in these patients. Article Published Date : Feb 28, 2018

Abstract Title: Effects of Whole-Body Vibration Versus Pilates Exercise on Bone Mineral Density in Postmenopausal Women: A Randomized and Controlled Clinical Trial. Abstract Source: J Geriatr Phys Ther. 2018 Feb 12. Epub 2018 Feb 12. PMID: 29443867 Abstract Author(s): Laís Campos de Oliveira, Raphael Gonçalves de Oliveira, Deise Aparecida de Almeida Pires-Oliveira Article Affiliation: Laís Campos de Oliveira Abstract: BACKGROUND AND PURPOSE: Decreased bone mineral density (BMD) is a common condition in postmenopausal women that can be managed with impact activities. Among the activities studied are the whole-body vibration (WBV) and muscle-strengthening exercises. The purpose of this study was to compare the effects of WBV versus Pilates exercise on BMD in postmenopausal women. METHODS: In this study, 51 postmenopausal women were randomized into 3 groups: vibration (n = 17), Pilates (n = 17), and control (n = 17). Outcomes were the areal bone mineral density (aBMD) (lumbar spine, femoral neck, total hip, trochanter, intertrochanter, and ward's area) assessed by dual-energy x-ray absorptiometry at baseline and follow-up. The interventions were performed 3 times a week for 6 months, totaling 78 sessions. The analysis was performed with intention-to-treat and covariance analyses adjusted for baseline outcomes. RESULTS: After 6 months, 96.1% of the participants completed the follow-up. The analyses demonstrated significant mean between-group differences in favor of the interventions: vibration versus control, for the aBMD of the lumbar spine (0.014 g/cm; 95% confidence interval [CI], 0.006-0.022; P= .018, d = 1.21) and trochanter (0.018 g/cm; 95% CI, 0.006-0.030; P = .012, d = 1.03); and Pilates versus control, for the aBMD of the lumbar spine (0.016 g/cm; 95% CI, 0.007-0.025; P = .008, d = 1.15) and trochanter (0.020 g/cm; 95% CI, 0.010-0.031; P = .005, d = 1.28). CONCLUSION: In postmenopausal women, 3 weekly sessions of WBV or Pilates administered for 6 months provided an equal effect on BMD. Article Published Date : Feb 11, 2018

Abstract Title: The preliminary effect of whole-body vibration intervention on improving the skeletal muscle mass index, physical fitness, and quality of life among older people with sarcopenia. Abstract Source: BMC Geriatr. 2018 01 17 ;18(1):17. Epub 2018 Jan 17. PMID: 29343219 Abstract Author(s): Shu-Fang Chang, Pei-Chen Lin, Rong-Sen Yang, Rea-Jeng Yang Article Affiliation: Shu-Fang Chang Abstract: BACKGROUND: Studies have shown that sarcopenia easily leads to difficulty moving, disability, and poor quality of life. However, researches on the use of whole-body vibration for older adults with sarcopenia living in institutions have been lacking. Therefore, the main objective of the present study was to investigate the effect of whole-body vibration intervention on improving the skeletal muscle mass index, physical fitness, and quality of life of older adults with sarcopenia living in institutions. METHODS: This study adopted a quasi-experimental, single-group, pretest-posttest design. The whole-body vibration intervention was performed over a 3-month period, in which the older adults trained 3 times per week; each training lasted 60 s with a break of 30 s for 10 repetitions. The older adults' skeletal muscle mass index, physical fitness and quality of life before and after the intervention of the whole-body vibration was collected. Concerning the statistical methods adopted, nonparametric method-based tests were employed. RESULTS: According to the results of analysis, after the intervention of the 12-week whole-body vibration, the skeletal muscle mass index (z = - 3.621, p = 0.000), physical fitness on standing on one foot (z = - 2.447, p = 0.014), shoulder-arm flexibility (z = - 3.159, p = 0.002), 8-ft up and go test (z = - 2.692, p = 0.009), hand grip strength (z = - 3.388, p = 0.009), and five repeatedsit-to-stand tests (z = - 2.936, p = 0.003), all improved significantly. Furthermore, concerning the quality of life of the older adults in the pretest and posttest, the improvements were statistically significant (z = - 2.533, p = 0.011). CONCLUSIONS: The study results showed the effect of whole-body vibration intervention on improving the skeletal muscle mass index, physical fitness, and quality of life of sarcopenic older people living in institutions and could serve as a crucial reference to health care professionals. Article Published Date : Jan 16, 2018

Abstract Title: Comparison of the Effectiveness of Whole Body Vibration in Stroke Patients: A Meta-Analysis. Abstract Source: Biomed Res Int. 2018 ;2018:5083634. Epub 2018 Jan 2. PMID: 29487869 Abstract Author(s): Yoo Jung Park, Sun Wook Park, Han Suk Lee Article Affiliation: Yoo Jung Park Abstract: Objectives: The goals of this study were to assess the effectiveness of WBV (whole body vibration) training through an analysis of effect sizes, identify advantages of WBV training, and suggest other effective treatment methods. Methods: Four databases, namely, EMBASE, PubMed, EBSCO, and Web of Science, were used to collect articles on vibration. Keywords such as"vibration"and"stroke"were used in the search for published articles. Consequently, eleven studies were selected in the second screening using meta-analyses. Results: The total effect size of patients with dementia in the studies was 0.25, which was small. The effect size of spasticity was the greatest at 1.24 (high), followed by metabolism at 0.99 (high), balance, muscle strength, gait, and circulation in the decreasing order of effect size. Conclusions: The effect sizes for muscle strength and balance and gait function, all of which play an important role in performance of daily activities, were small. In contrast, effect sizes for bone metabolism and spasticity were moderate. This suggests that WBV training may provide a safe, alternative treatment method for improving the symptoms of stroke in patients. Article Published Date : Dec 31, 2017

Abstract Title: Whole Body Vibration Retards Progression of Atherosclerosis via Insulin-Like Growth Factor 1 in Apolipoprotein E-Deficient Mice. Abstract Source: Biomed Res Int. 2018 ;2018:4934861. Epub 2018 Mar 7. PMID: 29707570 Abstract Author(s): He Wu, Yibo Zhang, Xuan Yang, Xian Li, Zhenya Shao, Zipeng Zhou, Yuanlong Li, Shuwen Pan, Chang Liu Article Affiliation: He Wu Abstract: Whole body vibration (WBV) has a marked impact on lipid metabolism and the endocrine system, which is related to the progression of atherosclerosis (AS). To investigate the effects of WBV, we measured the atherosclerotic plaque area of apolipoprotein E-knockout (ApoE) AS mice, which were trained by WBV (15 Hz, 30 min) for 12 weeks. Simultaneously, serum levels of lipids, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 1 receptor (IGF-1R), interleukin 6 (IL-6), and the mRNA and protein levels of the same in the aorta were compared between the control and WBV groups. The results indicated that WBV significantly reduced the atherosclerotic plaque area with lower very low-density lipoprotein (VLDL) and oxidized low-density lipoprotein (ox-LDL) in the blood. Moreover, the levels of IGF-1 in serum and expression of IL-6, IGF-1R, and p-IGF-1R protein in the mice aorta decreased significantly in the WBV group. In addition, we found that serum IGF-1 in mice increased to the highest concentration in 30 min after WBV for 10, 30, 60, and 120 minutes. These results suggested that appropriate WBV may delay the progression of AS, which was associated with acutely elevated serum IGF-1 and lower levels of IGF-1 and IL-6 in the aorta for long-term treatment. Article Published Date : Dec 31, 2017

Abstract Title: Effect of whole-body vibration exercise in preventing falls and fractures: a systematic review and meta-analysis. Abstract Source: BMJ Open. 2017 Dec 29 ;7(12):e018342. Epub 2017 Dec 29. PMID: 29289937 Abstract Author(s): Ditte Beck Jepsen, Katja Thomsen, Stinus Hansen, Niklas Rye Jørgensen, Tahir Masud, Jesper Ryg Article Affiliation: Ditte Beck Jepsen Abstract: OBJECTIVE: To investigate the effect of whole-body vibration exercise (WBV) on fracture risk in adults≥50 years of age. DESIGN: A systematic review and meta-analysis calculating relative risk ratios, fall rate ratio and absolute weighted mean difference using random effects models. Heterogeneity was estimated using I2 statistics, and the Cochrane Collaboration's risk of bias tool and the GRADE approach were used to evaluate quality of evidence and summarise conclusions. DATA SOURCES: The databases PubMed, Embase and the Cochrane Central Register from inception to April 2016 and reference lists of retrieved publications. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Randomised controlled trials examining the effect of WBV on fracture risk in adults≥50 years of age. The primary outcomes were fractures, fall rates and the proportion of participants who fell. Secondary outcomes were bone mineral density (BMD), bone microarchitecture, bone turnover markers and calcaneal broadband attenuation (BUA). RESULTS: 15 papers (14 trials) met the inclusion criteria. Only one study had fracture data reporting a non-significant fracture reduction (risk ratio (RR)=0.47, 95% CI 0.14 to 1.57, P=0.22) (moderate quality of evidence). Four studies (n=746) showed that WBV reduced the rate of falls with a rate ratio of 0.67 (95% CI 0.50 to 0.89, P=0.0006; I2=19%) (moderate quality of evidence). Furthermore, data from three studies (n=805) found a trend towards falls reduction (RR=0.76, 95% CI 0.48 to 1.20, P=0.24; I2=24%) (low quality of evidence). Finally, moderate to low quality of evidence showed no overall effect on BMD and only sparse data were available regarding microarchitecture parameters, bone turnover markers and BUA. CONCLUSIONS: WBV reduces fall rate but seems to have no overall effect on BMD or microarchitecture. The impact of WBV on fractures requires further larger adequately powered studies. This meta-analysis suggests that WBV may prevent fractures by reducing falls. PROSPERO REGISTRATION NUMBER: CRD42016036320; Pre-results. Article Published Date : Dec 28, 2017

Abstract Title: Home-based vibration assisted exercise as a new treatment option for scoliosis - A randomised controlled trial. Abstract Source: J Musculoskelet Neuronal Interact. 2017 Dec 1 ;17(4):259-267. PMID: 29199184 Abstract Author(s): S Langensiepen, C Stark, R Sobottke, O Semler, J Franklin, M Schraeder, J Siewe, P Eysel, E Schoenau Article Affiliation: S Langensiepen Abstract: OBJECTIVES: The aim of this study was to evaluate the effect of scoliosis specific exercises (SSE) on a side-alternating whole body vibration platform (sWBV) as a home-training program in girls with adolescent idiopathic scoliosis (AIS). METHODS: 40 female AIS patients (10-17 years) wearing a brace were randomly assigned to two groups. The intervention was a six months, home-based, SSE program on a sWBV platform five times per week. Exercises included standing, sitting and kneeling. The control group received regular SSE (treatment as usual). The Cobb angle was measured at start and after six months. Onset of menarche was documented for sub-group analysis. RESULTS: The major curve in the sWBV group decreased significantly by -2.3° (SD±3.8) (95% CI -4.1 to -0.5; P=0.014) compared to the difference in the control group of 0.3° (SD±3.7) (95% CI -1.5 to 2.2; P=0.682) (P=0.035). In the sWBV group 20% (n=4) improved, 75% (n=15) stabilized and 5% (n=1) deteriorated by ≥5°. In the control group 0% (n=0) improved, 89% (n=16)stabilized and 11% (n=2) deteriorated. The clinically largest change was observed in the 'before-menarche' sub-group. CONCLUSIONS: Home-based SSE combined with sWBV for six months counteracts the progression of scoliosis in girls with AIS; the results were more obvious before the onset of the menarche. Article Published Date : Nov 30, 2017

Abstract Title: Efficacy and safety of whole body vibration in maintenance hemodialysis patients - A pilot study. Abstract Source: J Musculoskelet Neuronal Interact. 2017 Dec 1 ;17(4):268-274. PMID: 29199185 Abstract Author(s): L Seefried, F Genest, N Luksche, M Schneider, G Fazeli, M Brandl, U Bahner, A A Heidland Article Affiliation: L Seefried Abstract: OBJECTIVES: The aim of this study was to assess safety and effectiveness of Whole Body Vibration exercise (WBV) to improve physical performance and parameters of inflammation in patients on maintenance hemodialysis (MHD). METHODS: Prospective, open-label trial in n=14 patients on maintenance hemodialysis. Participants performed WBV twice weekly for 12 weeks before (n=8) or after (n=6) hemodialysis sessions. The primary endpoint was physical performance assessed by the Short-Physical-Performance-Battery (SPPB). Secondary endpoints included established parameters of musculoskeletal assessment and blood chemistry. RESULTS: As compared to baseline, physical performance (SPPB) improved significantly (p=0.035). Moderate advances were also seen for 6-Minute-Walking test, Timed-up-and-go test, jumping height and handgrip strength. Improvements were particularly pronounced in subjects with seriously impaired baseline performance. Skeletal muscle index showed a tendency to better values. Laboratory data exhibited a significant reduction of white blood cell count and a trend to lower levels of hsCRP. WBV was generally well tolerated. Two events of clinically significant blood pressure decline occurred in patients exercising after dialysis sessions. CONCLUSIONS: Results of this pilot study suggest effectiveness and safety of WBV in hemodialysis patients. Beneficial effects may affect both, parameters of physical performance and systemic inflammatory activity, which should be verified in larger scale clinical trials. Article Published Date : Nov 30, 2017

Abstract Title: Whole body vibration added to treatment as usual is effective in adolescents with depression: a partly randomized, three-armed clinical trial in inpatients. Abstract Source: Eur Child Adolesc Psychiatry. 2017 Nov 8. Epub 2017 Nov 8. PMID: 29119301 Abstract Author(s): Heidrun Lioba Wunram, Stefanie Hamacher, Martin Hellmich, Maxi Volk, Franziska Jänicke, Franziska Reinhard, Wilhelm Bloch, Philipp Zimmer, Christine Graf, Eckhard Schönau, Gerd Lehmkuhl, Stephan Bender, Oliver Fricke Article Affiliation: Heidrun Lioba Wunram Abstract: There is growing evidence for the effectiveness of exercise in the treatment of adult major depression. With regard to adolescents, clinical trials are scarce. Due to the inherent symptoms of depression (lack of energy, low motivation to exercise), endurance training forms could be too demanding especially in the first weeks of treatment. We hypothesized that an easy-to-perform passive muscular training on a whole body vibration (WBV) device has equal anti-depressive effects compared to a cardiovascular training, both administered as add-ons to treatment as usual (TAU). Secondly, we presumed that both exercise interventions would be superior in their response, compared to TAU. In 2 years 64 medication-naïve depressed inpatients aged 13-18, were included. Both exercise groups fulfilled a supervised vigorous training for 6 weeks. Depressive symptoms were assessed by self-report ("Depressions Inventar für Kinder und Jugendliche"-DIKJ) before intervention and after weeks 6, 14 and 26. Compared to TAU, both groups responded earlier and more strongly measured by DIKJ scores, showing a trend for the WBV group after week 6 (p = 0.082). The decrease became statistically significant for both intervention groups after week 26 (p = 0.037 for ergometer and p = 0.042 for WBV). Remission rates amounted to 39.7% after week 6 and 66% after week 26, compared to 25% after week 26 in TAU. These results provide qualified support for the effectiveness of exercise as add-on treatment for medication-naïve depressed adolescents. The present results are limited by the not randomized control group. Article Published Date : Nov 07, 2017

Abstract Title: The effects of whole body vibration combined biofeedback postural control training on the balance ability and gait ability in stroke patients. Abstract Source: J Phys Ther Sci. 2017 Nov ;29(11):2022-2025. Epub 2017 Nov 24. PMID: 29200649 Abstract Author(s): Yo-Han Uhm, Dae-Jung Yang Article Affiliation: Yo-Han Uhm Abstract: [Purpose] The purpose of this study was to examine the effect of biofeedback postural control training using whole body vibration in acute stroke patients on balance and gait ability. [Subjects and Methods] Thirty stroke patients participated in this study and were divided into a group of 10, a group for biofeedback postural control training combined with a whole body vibration, one for biofeedback postural control training combined with an aero-step, and one for biofeedback postural control training. Biorescue was used to measure the limits of stability, balance ability, and Lukotronic was used to measure step length, gait ability. [Results] In the comparison of balance ability and gait ability between the groups for before and after intervention, Group I showed a significant difference in balance ability and gait ability compared to Groups II and III. [Conclusion] This study showed that biofeedback postural control training using whole body vibration is effective for improving balance ability and gait ability in stroke patients. Article Published Date : Oct 31, 2017

Abstract Title: Effects of whole body vibration therapy in pain, function and depression of the patients with fibromyalgia. Abstract Source: Complement Ther Clin Pract. 2017 Aug ;28:200-203. Epub 2017 Jun 30. PMID: 28779930 Abstract Author(s): Alp Alev, Adalı Mihriban, Efe Bilge, Elyıldırım Ayça, Karabulut Merve, Coşkun Şeyma, Ertem Uğur, Bilgiç Adnan, Karakullukçuoğlu Zeynel, Günay Selim Mahmut Article Affiliation: Alp Alev Abstract: AIM: Aim of the study is to search the effects of whole body vibration (WBV) in fibromyalgia patients. MATERIALS AND METHODS: In this single blind study 20 fibromyalgia patients were diagnosed according to 2010 American College of Rheumatology criteria whom participated in the study with the mean age of 57 ± 7 (years). Participants were randomized into 2 equal groups. In the intervention group (n = 10), 6 different types of exercises were combined with 30 hz frequency, 2 mm amplitude WBV for 4 weeks, The control group (n = 10) performed the same exercises on the same platform without vibration. The patients were assessed at baseline, at the 3rd and 6th months by Visual Analogue Scale (VAS), Fibromyalgia Impact Questionnaire (FIQ) and Beck Depression Inventory (BDI). RESULTS: Only FIQ score was significantly better in the treatment group at the 6th month evaluation (p = 0.043). CONCLUSION: WBV is found to be effective in reducing symptoms of fibromyalgia. Article Published Date : Jul 31, 2017

Abstract Title: The effects of milk intake and whole-body vibration exercise on bone mineral density in elderly women in nursing homes. Abstract Source: J Phys Ther Sci. 2017 Jul ;29(7):1125-1128. Epub 2017 Jul 15. PMID: 28744030 Abstract Author(s): So Min Lee, Sungchul Kim, Chae-Gil Lim Article Affiliation: So Min Lee Abstract: [Purpose] This study was designed to investigate the effects of lactose-free milk intake and whole-body vibration exercises on bone density in elderly female nursing home residents who had difficulty exercising outdoors and had not consumed milk. [Subjects and Methods] Twenty seven elderly women aged 70 or older from 3 nursing homes located in Incheon, Korea participated in the study. The experimental group (n=13) carried out whole-body vibration exercises and drank lactose-free milk, while the control group (n=14) continued to live their ordinary nursing home lives. Weight, BMI, T-scores, and Z-scores were compared between the experimental and control groups after 12 weeks. [Results] The comparison of changes in weight and BMI in the control group before and after the 12-week experiment found no statistically significant differences. However, bone mineral density was significantly different, with the T-score significantly decreasing from -2.99 to -3.48 and the Z-score decreasing from -1.87 to -2.58. The other comparisons of physical changes in the control group before and after the 12-week experiment found no statistical significance. [Conclusion] The results indicate that regular consumption of lactose-free milk and performing whole-body vibration exercises can delay the progression of bone density loss in older adults in nursing homes; adequate exercise and calcium intake could eventually help prevent fractures. Article Published Date : Jun 30, 2017

Abstract Title: [Effects of Low-magnitude Whole Body Vibration (WBV) on Knee Osteoarthritis in Rabbits]. Abstract Source: Sichuan Da Xue Xue Bao Yi Xue Ban. 2017 Jul ;48(4):537-542. PMID: 28752971 Abstract Author(s): Jun-Bo Wang, Si-Jia Liu, Hong-Ying Chen, Pu Wang Article Affiliation: Jun-Bo Wang Abstract: OBJECTIVE: To determine the effects of low-magnitude whole body vibration (WBV) on the structure and function of subchondral trabecular bones, cartilage degradation, bone/cartilage turnover, and osteoarthritis (OA) joint function. METHODS: Knee osteoarthritis model was established in 96 rabbits through left anterior cruciate ligament transaction (ACLT). The rabbits were randomly divided into six groups: ACLT control group, WBV+ACLT group (five subgroups, each comprising 16 rabbits receiving 5 Hz, 10 Hz, 20 Hz, 30 Hz and 40 Hz WBV, respectively, with 2-4 mm amplitude for 40 min/d and 5 d/week over a period of 8 weeks). Joint function was tested via weight-bearing asymmetry. The microarchitecture of subchondral trabecular bones was examined using vivo micro-computed tomography (micro-CT). Cartilage samples from knee joints were taken for gross morphology and histology examinations. Serum samples were taken to detect cartilage oligomeric matrix protein (COMP), C-terminal telopeptide of typeⅠ collagen (CTX)-Ⅰ and urine CTX-Ⅱ. RESULTS: Knee joint pain decreased with 10 Hz (P<0.05) and 20 Hz WBV treatment (P<0.05) , but increased with 40 Hz treatment (P<0.05). The micro-CT results showed that articular cartilage increased first, peaked at 20 Hz, and then decreased (P<0.05) . With increased frequency of WBV, the trabecular number, subchondral bone thickness and bone volume fraction increased, serum CTX-Ⅰ decreased, COMP and CTX-Ⅱ increased, especially at 20 Hz (P<0.05). CONCLUSION: Lower frequency (20 Hz) WBV can improve bone microstructure, increase bone turnover, delay cartilage degeneration and improve limb function of rabbits with OA. Article Published Date : Jun 30, 2017

Abstract Title: The effect of a whole-body vibration therapy on the sitting balance of subacute stroke patients: a randomized controlled trial. Abstract Source: Top Stroke Rehabil. 2017 Mar 23:1-6. Epub 2017 Mar 23. PMID: 28335701 Abstract Author(s): Jong Hwa Lee, Sang Beom Kim, Kyeong Woo Lee, Sook Joung Lee, Hyuntae Park, Dong Won Kim Article Affiliation: Jong Hwa Lee Abstract: BACKGROUND: The use of a whole-body vibration (WBV) therapy has recently been applied and investigated as a rehabilitation method for subacute stroke patients. OBJECTIVE: To evaluate the effects of a WBV therapy on recovery of balance in subacute stroke patients who were unable to gain sitting balance. METHODS: The conventional rehabilitation group (CG) received conventional physical therapy, including sitting balance training by a physical therapist, for 30 min a one session, for twice a day for five days a week for two weeks. The whole-body vibration group (VG) received one session of conventional physical therapy, and received WBV therapy instead of conventional physical therapy for 30 min a day for five days a week for two weeks. RESULTS: There were 15 patients in the CG and 15 patients in the VG who completed the two-week therapy. After the two-week therapy, both groups showed functional improvement. Patients in the VG improved functional ambulation categories, Berg balance scale, trunk impairment scale scores. But, no statistically significant correlations between the therapeutic methods and outcomes were observed in either group. CONCLUSION: Our results suggest that WBV therapy led to improvement of the recovery in balance recovery for subacute stroke patients. Because the WBV therapy was as effective as conventional physical therapy, we can consider a WBV therapy as a clinical method to improve the sitting balance of subacute stoke patients. Article Published Date : Mar 22, 2017

Abstract Title: Whole-body vibration mimics the metabolic effects of exercise in male leptin receptor deficient mice. Abstract Source: Endocrinology. 2017 Mar 15. Epub 2017 Mar 15. PMID: 28323991 Abstract Author(s): Meghan E McGee-Lawrence, Karl H Wenger, Sudipta Misra, Catherine L Davis, Norman K Pollock, Mohammed Elsalanty, Kehong Ding, Carlos M Isales, Mark W Hamrick, Joanna R Erion, Marlena Wosiski-Kuhn, Phonepasong Arounleut, Mark P Mattson, Roy G Cutler, Jack C Yu, Alexis M Stranahan Article Affiliation: Meghan E McGee-Lawrence Abstract: Whole-body vibration has gained attention as a potential exercise mimetic, but direct comparisons with the metabolic effects of exercise are scarce. To determine whether whole-body vibration recapitulates the metabolic and osteogenic effects of physical activity, we exposed male wildtype (Wt) and leptin receptor deficient (db/db) mice to daily treadmill exercise or whole-body vibration for three months. Body weights were analyzed and compared with Wt and db/db mice that remained sedentary. Glucose and insulin tolerance testing revealed comparable attenuation of hyperglycemia and insulin resistance in db/db mice following treadmill exercise or whole-body vibration. Both interventions reduced body weight in db/db mice and normalized muscle fiber diameter. Treadmill exercise and whole-body vibration also attenuated adipocyte hypertrophy in visceral adipose tissue and reduced hepatic lipid content in db/db mice. Although the effects of leptin receptor deficiency on cortical bone structure were not eliminated by either intervention, exercise and whole-body vibration increased circulating levels of osteocalcin in db/db mice. In the context of increased serum osteocalcin, the modest effects of TE and WBV on bone geometry, mineralization, and biomechanics may reflect subtle increases in osteoblast activity in multiple areas of the skeleton. Taken together, these observations indicate that whole-body vibration recapitulates the effects of exercise on metabolism in type 2 diabetes. Article Published Date : Mar 14, 2017

Abstract Title: Whole-body vibration training as a workplace-based sports activity for employees with chronic low-back pain. Abstract Source: Scand J Med Sci Sports. 2017 Feb 10. Epub 2017 Feb 10. PMID: 28185300 Abstract Author(s): Tobias S Kaeding, Annika Karch, Rebecca Schwarz, Tatjana Flor, Torge-Christian Wittke, Momme Kück, Georg Böselt, Uwe Tegtbur, Lothar Stein Article Affiliation: Tobias S Kaeding Abstract: INTRODUCTION: The goal of this randomized and controlled study is to examine whether whole-body vibration (WBV) training is able to reduce back pain and physical disability in seated working office employees with chronic low-back pain in a real-world setting. MATERIALS AND METHODS: A total of 41 subjects (68.3% female/mean age 45.5± 9.1 years/mean BMI 26.6 ± 5.2) were randomly allocated to an intervention group (INT (n= 21)) or a control group (CON (n=20). The INT participated in WBV training 2.5 times per week for 3 months. The primary outcome was the change in the Roland and Morris disability questionnaire (RMQ) score over the study period. In addition, secondary outcomes included changes in the Oswestry Disability Index (ODI), the Work-Ability-Index Questionnaire (WAI), the quality of life questionnaire SF-36, the Freiburger activity questionnaire and an isokinetic test of the musculature of the trunk. RESULTS: Compliance with the intervention in the INT reached a mean of 81.1%± 31.2% with no long-lasting unwanted side effects. We found significant positive effects of 3 months of WBV training in the INT compared to the CON regarding the RMQ (p=0.027), the ODI (p=0.002), the SF-36 (p=0.013), the Freiburger activity questionnaire (p=0.022), the post-interventional sick leave in the INT (p=0.008) and trends regarding a positive effect of the intervention on the muscular capacity of the muscles of the trunk in flexion. CONCLUSIONS: WBV training seems to be an effective, safe and suitable intervention for seated working employees with chronic low-back pain. This article is protected by copyright. All rights reserved. Article Published Date : Feb 09, 2017

Abstract Title: Effects of 24 Weeks of Whole Body Vibration Versus Multicomponent Training on Muscle Strength and Body Composition in Postmenopausal Women: A Randomized Controlled Trial. Abstract Source: Rejuvenation Res. 2017 Jan 19. Epub 2017 Jan 19. PMID: 27998241 Abstract Author(s): Elena Marín-Cascales, Pedro E Alcaraz, Jacobo A Rubio-Arias Article Affiliation: Elena Marín-Cascales Abstract: The purposes of this study were to analyze the impact of 24 weeks of vibratory and multicomponent training (MT) and to determine what type of training creates greater adaptations on body composition and isokinetic strength of the knee and ankle joints in postmenopausal women. Thirty-eight women (60.0 ± 6.3 years) were randomly assigned to whole body vibration group (WBVG), multicomponent training group (MTG), or a control group. A significant decrease in total fat mass was observed in experimental groups. There were no changes in total lean mass and total bone mineral density in both groups. WBVG and MTG showed significant increases in isokinetic strength for knee extensors at 60°/s and at 270°/s. Regarding the ankle joint, there were significant increments in strength for plantar flexion at 60°/s in WBVG and at 120°/s in the two trainings groups. MTG showed a significant increase in strength for dorsiflexion at 60°/s. With respect to eversion and inversion, WBVG and MTG improved strength at 60°/s. Also, the WBVG showed increased strength in the ankle evertors at 120°/s and both groups showed increased strength in the ankle invertors at 120°/s. Twenty-four weeks of whole body vibration or MTs result in positive modifications in total fat mass. These trainings are effective in improving knee extension and stabilizer muscles of the ankle joint strength. Article Published Date : Jan 18, 2017

Abstract Title: QUALITY OF LIFE OF PATIENTS WITH METABOLIC SYNDROME IS IMPROVED AFTER WHOLE BODY VIBRATION EXERCISES. Abstract Source: Afr J Tradit Complement Altern Med. 2017 ;14(4 Suppl):59-65. Epub 2017 Jul 7. PMID: 28740945 Abstract Author(s): Rafaelle Pacheco Carvalho-Lima, Danúbia C Sá-Caputo, Eloá Moreira-Marconi, Carla Dionello, Laisa Liane Paineiras-Domingos, Cintia Renata Sousa-Gonçalves, Daniele Soares Morel, Eric Heleno Frederico, Mario F Neves, Ricardo Oliveira, Wille Oigman, Pedro J Marin, Dulciane N Paiva, Mario Bernardo-Filho Article Affiliation: Rafaelle Pacheco Carvalho-Lima Abstract: BACKGROUND: Whole body vibration exercises (WBVE) improve the quality of life (QoL) of different populations. Metabolic syndrome patients (MetS) may be favored by physical activity. Questionnaires are used to assess the QoL. The aim was to evaluate the QoL of patients with MetS that have undergone WBVE with a brief WHOQOL (WHOQOL-BREF). MATERIAL AND METHODS: MetS patients were randomly divided into three groups: (i) control group (CG), (ii) treated with WBVE once per week (WBVE1) and (iii) treated with WBVE twice per week (WBVE2). In the first session, the patient was sat in a chair in front of the platform with the feet on its base in 3 peak to peak displacements (2.5, 5.0 and 7.5 mm) and frequency of 5 Hz was used. From the second to the last session, patients were subjected to the same protocol, however they were standing on the base of the platform and the frequency was increased up to 14 Hz. The patients fulfilled the WHOQOL-BREF before the first and after the last sessions. Cronbach coefficients were determined to each domain of the WHOQOL-BREF and test Wilcoxon (p<0.05) was used. RESULTS: The patients of the WBVE1 group had improvements in the physical, psychological and environment domains while in the WBVE2, the improvements were in the physical and social relationships domain of the WHOQOL-BREF. CONCLUSION: It was observed that the WBVE in a protocol (one or two times per week) with a progressive and increased frequency improves the QoL of patients with MetS in different domains of the WHOQOL-BREF. Article Published Date : Dec 31, 2016

Abstract Title: A randomized exploratory phase 2 study in patients with chemotherapy-related peripheral neuropathy evaluating whole-body vibration training as adjunct to an integrated program including massage, passive mobilization and physical exercises. Abstract Source: Exp Hematol Oncol. 2017 ;6:5. Epub 2017 Feb 7. PMID: 28194306 Abstract Author(s): Stefan S Schönsteiner, Heidi Bauder Mißbach, Axel Benner, Silja Mack, Thomas Hamel, Michael Orth, Bernhard Landwehrmeyer, Sigurd D Süßmuth, Carolin Geitner, Regine Mayer-Steinacker, Anneliese Riester, Andrea Prokein, Elfriede Erhardt, Jelena Kunecki, Anna M Eisenschink, Rainer Rawer, Hartmut Döhner, Elisabeth Kirchner, Richard F Schlenk Article Affiliation: Stefan S Schönsteiner Abstract: BACKGROUND: Chemotherapy-induced polyneuropathy (CIPN) is a common toxicity after chemotherapy, immunomodulatory drugs or proteasome inhibitors, which is difficult to treat and may also have impact on quality of life. The objective of the study was to evaluate whole-body vibration (WBV) on the background of an integrated program (IP) including massage, passive mobilization and physical exercises on CIPN. PATIENTS AND METHODS: In an exploratory phase-2 study patients with CIPN (NCI CTC grade 2/3) were randomized for WBV plus IP (experimental) to IP alone (standard). 15 training sessions within 15 weeks were intended. As primary endpoint we used chair-rising test (CRT) to assess physical fitness and coordination. In addition, locomotor and neurological tests and self-assessment tools were performed. RESULTS: A total 131 patients with CIPN were randomized (standard, n = 65; experimental, n = 66). The median age was 60 (range 24-71) years; 44 patients had haematological neoplasms and 87 solid tumors. At baseline, all patients presented with an abnormal CRT. Fifteen (standard) and 22 (experimental) patients left the program due to progression/relapse or concomitant disease. There was no significant difference in the proportion of patients with normal CRT (<10 s) at follow up between experimental (68%) and standard (56%) (p = 0.20). All patients experienced less symptoms and pain (p < 0.001) and had improved CRT (p < 0.001) over time. WBV was significantly associated with a higher reduction of time needed for CRT (p = 0.02) and significantly improved warm-detection-threshold comparing baseline to follow-up assessment (p = 0.02). CONCLUSION: Whole-body vibration on the background of an IP may improve physical fitness and coordination in patients suffering from CIPN. Trial registration Retrospectively registered at http://www.iscrtn.com (ISRCTN 51361937) and http://www.clinicaltrials.gov (NCT02846844). Article Published Date : Dec 31, 2016

Abstract Title: Cardiopulmonary response during whole-body vibration training in patients with severe COPD. Abstract Source: ERJ Open Res. 2017 Jan ;3(1). Epub 2017 Mar 14. PMID: 28326310 Abstract Author(s): Rainer Gloeckl, Petra Richter, Sandra Winterkamp, Michael Pfeifer, Christoph Nell, Jeffrey W Christle, Klaus Kenn Article Affiliation: Rainer Gloeckl Abstract: Several studies in patients with chronic obstructive pulmonary disease (COPD) have shown that whole-body vibration training (WBVT) has beneficial effects on exercise capacity. However, the acute cardiopulmonary demand during WBVT remains unknown and was therefore investigated in this study. Ten patients with severe COPD (forced expiratory volume in 1 s: 38±8% predicted) were examined on two consecutive days. On day one, symptom-limited cardiopulmonary exercise testing was performed on a cycle ergometer. The next day, six bouts of repeated squat exercises were performed in random order for one, two or three minutes either with or without WBVTwhile metabolic demands were simultaneously measured. Squat exercises with or without WBVT induced comparable ventilatory efficiency (minute ventilation (VE)/carbon dioxide production (V'CO2 ): 38.0±4.4 with WBVT versus 37.4±4.1 without, p=0.236). Oxygen uptake after 3 min of squat exercises increased from 339±40 mL·min(-1) to 1060±160 mL·min(-1) with WBVT and 988±124 mL min(-1) without WBV (p=0.093). However, there were no significant differences between squat exercises with and without WBVT in oxygen saturation (90±4% versus 90±4%, p=0.068), heart rate (109±13 bpm versus110±15 bpm, p=0.513) or dyspnoea (Borg scale 5±2 versus 5±2, p=0.279). Combining squat exercises with WBVT induced a similar cardiopulmonary response in patients with severe COPD compared to squat exercises without WBVT. Bearing in mind the small sample size, WBVT might be a feasible and safeexercise modality even in patients with severe COPD. Article Published Date : Dec 31, 2016

Abstract Title: Whole-body vibration training improves balance control and sit-to-stand performance among middle-aged and older adults: a pilot randomized controlled trial. Abstract Source: Eur Rev Aging Phys Act. 2017 ;14:11. Epub 2017 Jul 18. PMID: 28729887 Abstract Author(s): Ming-Chen Ko, Long-Shan Wu, Sangwoo Lee, Chien-Chun Wang, Po-Fu Lee, Ching-Yu Tseng, Chien-Chang Ho Article Affiliation: Ming-Chen Ko Abstract: BACKGROUND: Aging is associated with decreased balance, which increases falling risk. The objective of the current study was to determine the feasibility and effects of whole-body vibration (WBV) training on knee extensor muscle power, limits of stability, and sit-to-stand performance among community-dwelling middle-aged and older adults in the United States. METHODS: A randomized pilot study with participant blinding was conducted. Feasibility outcomes included recruitment and compliance rate. Twenty-nine community-dwelling older adults were randomly assigned to perform body-weight exercises with either an individualized vibration frequency and amplitude, a fixed vibration frequency and amplitude, or no vibration. Isokinetic knee extensor power, limits of stability, and sit-to-stand tests were conducted before beginning the exercises (baseline) and after 8 weeks of training. RESULTS: With a favorable recruitment rate (58%) and compliance rates (attrition 9%; adherence 85%), the intervention was deemed feasible. The limits of stability endpoint excursion score for the individualized frequency-amplitude group was increased by 8.8 (12.9%; P = 0.025) after training, and that group's maximum excursion score was increased by 9.2 (11.5%; P = 0.006) after training. The average weight transfer time score was significantly decreased by 0.2 s in the fixed group. The participants in the individualized group demonstrated a significant increase (3.2%) in weight rising index score after 8 weeks of WBV training. CONCLUSIONS: WBV training is feasible for use with elderly people, and this study achieved good recruitment and compliance. The present paper suggests that 8 weeks of WBV training improves limits of stability and sit-to-stand performance. Future studies must determine whether WBV training improves other factors that affect posture control. TRIAL REGISTRATION: This study was registered at the Texas Woman's University Institutional Review Board [TWU IRB 17632] on the 3rd of November 2014. Article Published Date : Dec 31, 2016

Abstract Title: WHOLE-BODY VIBRATION EXERCISE IS WELL TOLERATED IN PATIENTS WITH DUCHENNE MUSCULAR DYSTROPHY: A SYSTEMATIC REVIEW. Abstract Source: Afr J Tradit Complement Altern Med. 2017 ;14(4 Suppl):2-10. Epub 2017 Jul 7. PMID: 28740938 Abstract Author(s): Eloá Moreira-Marconi, Danubia C Sá-Caputo, Carla F Dionello, Eliane O Guedes-Aguiar, Cintia R Sousa-Gonçalves, Danielle S Morel, Laisa L Paineiras-Domingos, Patricia L Souza, Cristiane R Kütter, Rebeca G Costa-Cavalcanti, Glenda Costa, Patricia C Paiva, Claudia Figueiredo, Samuel Brandão-Sobrinho-Neto, Christina Stark, Marianne Unger, Mario Bernardo-Filho Article Affiliation: Eloá Moreira-Marconi Abstract: BACKGROUND: Duchenne muscular dystrophy (DMD) is caused by a defective gene located on the X-chromosome, responsible for the production of the dystrophin protein. Complications in the musculoskeletal system have been previously described in DMD patients. Whole body vibration exercise (WBVE) is a treatment that improves musculoskeletal function in movement disorders. The aim of this study was to review the effects of WBVE on functional mobility, bone and muscle in DMD patients. MATERIALS AND METHODS: Four databases were searched. Three eligible studies were found; all three conclude the management of DMD patients with WBV was clinically well tolerated. The studies used a side-alternating WBV system, frequencies 7 - 24 Hz; and amplitudes 2 - 4 mm. RESULTS: A work indicates that a temporary increase in creatine kinase in DMD during the first days of WBV was observed, but other authors did not find changes. No significant changes in bone mass, muscle strength or bone markers. Some patients reported subjective functional improvement during training. Interpretation. CONCLUSION: It is concluded that WBV seems to be a feasible and well tolerated exercise modality in DMD patients. Article Published Date : Dec 31, 2016

Abstract Title: Effects of controlled whole-body vibration training in improving fall risk factors among individuals with multiple sclerosis: A pilot study. Abstract Source: Disabil Rehabil. 2016 Dec 15:1-8. Epub 2016 Dec 15. PMID: 27976932 Abstract Author(s): Feng Yang, Marcia Finlayson, Francois Bethoux, Xiaogang Su, Loretta Dillon, Hector M Maldonado Article Affiliation: Feng Yang Abstract: PURPOSE: The purpose of this study was to systematically examine the effect of an 8-week controlled whole-body vibration training on improving fall risk factors and the bone mineral density among people with multiple sclerosis (PwMS). METHODS: This study adopted a single group pre-test-post-test design. Twenty-five PwMS (50.3 years SD 14.1) received vibration training on a side-alternating vibration platform. Each training session was repeated three times every week for 8 weeks. Prior to and following the 8-week training course, a battery of fall risk factors were evaluated: the body balance, functional mobility, muscle strength, range of motion, and fear of falling. Bone density at both calcanei was also assessed. RESULTS: Twenty-two participants completed the study. Compared with pre-test, almost all fall risk factors and the bone density measurement were significantly improved at post-test, with moderate to large effect sizes varying between 0.571 and 1.007. CONCLUSIONS: The 8-week vibration training was well accepted by PwMS and improved their fall risk factors. The important findings of this study were that vibration training may increase the range of motion of ankle joints on the sagittal plane, lower the fear of falling, and improve bone density. IMPLICATIONS FOR REHABILITATION An 8-week vibration training course could be well-accepted by people with multiple sclerosis (MS). Vibration training improves the risk factors of falls in people living with MS. Vibration training could be a promising rehabilitation intervention in individuals with MS. Article Published Date : Dec 14, 2016

Abstract Title: Whole Body Vibration Increases Subsequent Sprint Performance in Well-Trained Cyclists. Abstract Source: Int J Sports Physiol Perform. 2016 Dec 14:1-18. Epub 2016 Dec 14. PMID: 27967282 Abstract Author(s): Bent R Rønnestad, Gunnar Slettaløkken Falch, Stian Ellefsen Article Affiliation: Bent R Rønnestad Abstract: PURPOSE: Postactivation potentiation (PAP) exercise with added whole-body vibration (WBV) has been suggested as a potential way to acutely improve sprint performance. In cycling, there are many competitions and situations where sprinting abilities are important. In the present study we investigated the effect of adding WBV to warm-up procedures on subsequent cycle sprint performance. METHODS: Eleven well-trained cyclists participated in the study. All cyclists performed a familiarization session before two separate test sessions in randomized order. Each session included a standardized warm-up followed by one of the following preconditioning exercises; 30 s of half-squats without WBV or 30 s of half-squats with WBV at 40 Hz. A 15 s Wingate sprint was performed one minute after the preconditioning exercise. RESULTS: Performing preconditioning exercise with WBV at 40 Hz resulted in superior peak power output compared to preconditioning exercise without WBV (1413±257 W vs. 1353±213 W, p=0.04) and a tendency towards superior mean power output during a 15 s all-out sprint (850±119 W vs. 828±101 W, p=0.08). Effect sizes showed a moderate practical effect of WBV vs. no WBV on both peak and mean power output. CONCLUSIONS: In conclusion, preconditioning exercise performed with WBV at 40 Hz seems to have a positive effect on cycling sprint performance in young well-trained cyclists. This suggests that athletes can incorporate body-loaded squats with WBV into preparations to specific sprint training to improve the quality of the sprint training and also in order to improve sprint performance in relevant competitions. Article Published Date : Dec 13, 2016

Abstract Title: Low-Volume Whole-Body Vibration Training Improves Exercise Capacity in Subjects With Mild to Severe COPD. Abstract Source: Respir Care. 2016 Dec 6. Epub 2016 Dec 6. PMID: 27923937 Abstract Author(s): Marc Spielmanns, Tobias Boeselt, Rainer Gloeckl, Anja Klutsch, Henrike Fischer, Henryk Polanski, Christoph Nell, Jan H Storre, Wolfram Windisch, Andreas R Koczulla Article Affiliation: Marc Spielmanns Abstract: BACKGROUND: The objective of this study was to investigate the benefits of a low-volume out-patient whole-body vibration training (WBVT) program on exercise capacity in comparison with a calisthenics training program in subjects with COPD. METHODS: In this single-center randomized controlled trial, 29 subjects with mild to severe COPD were randomized to WBVT or to calisthenics training, including relaxation and breathing retraining in combination with calisthenics exercises. Both groups equally exercised for a duration of 3 months with 2 sessions of 30 min/week. Outcome parameters were 6-min walk distance (6MWD, primary outcome), 5-repetition sit-to-stand test, leg press peak force, Berg balance scale, St George Respiratory Questionnaire, and COPD assessment test. RESULTS: Twenty-seven subjects completed the study (WBVT, n = 14; calisthenics training program, n = 13). Baseline characteristics between groups were comparable. Subjects in the WBVT group significantly improved median (interquartile range) 6MWD (+105 [45.5-133.5] m, P = .001), sit-to-stand test (-2.3 [-3.1 to -1.3] s, P = .001), peak force (28.7 [16.7-33.3] kg, P = .001), and Berg balance scale (1.5 [0.0-4.0]points, P = .055). Changes in 6MWD, sit-to-stand test, and leg press peak force were also found to be significantly different between groups in favor of the WBVT group. Only the between-group difference of the COPD assessment test score was in favor of the calisthenics training group (P = .02). CONCLUSIONS: A low-volume WBVT program resulted in significantly and clinically relevant larger improvements in exercise capacity compared with calisthenics exercises in subjects with mild to severe COPD. Article Published Date : Dec 05, 2016

Abstract Title: Whole-Body Vibration Training Improves Heart Rate Variability and Body Fat Percentage in Obese Hispanic Postmenopausal Women. Abstract Source: J Aging Phys Act. 2016 Dec 5:1-25. Epub 2016 Dec 5. PMID: 27918705 Abstract Author(s): Gregory Severino, Marcos Sanchez-Gonzalez, Michelle Walters-Edwards, Michael Nordvall, Oksana Chernykh, Jason Adames, Alexei Wong Article Affiliation: Gregory Severino Abstract: The present study examined the effects of a 6-week whole body vibration training (WBVT) regimen on heart rate variability (HRV) and body composition in obese Hispanic postmenopausal women. Participants were randomly assigned to either WBVT (n=13) or non-exercising control group (n=14). HRV and body composition were measured before and after 6 weeks. There was a significant group x time interaction (P<0.05) for heart rate, sympathovagal balance and body fat percentage (BF%) such that all significantly decreased (P<0.05); and R-R intervals which significant increased (P<0.05) following WBVT compared to no changes after control. The changes in sympathovagal balance were correlated with changes in BF% (r=0.63, P<0.05). Our findings indicate that WBVT improves HRV and BF% in obese Hispanic postmenopausal women. The improvement in BF% partially explained the decrease in sympathovagal balance. Since obese and older individuals are at increased risk of developing cardiovascular diseases, they could potentially benefit from WBVT. Article Published Date : Dec 04, 2016

Abstract Title: Whole-Body Vibration Exercise Therapy Improves Cardiac Autonomic Function and Blood Pressure in Obese Pre- and Stage 1 Hypertensive Postmenopausal Women. Abstract Source: J Altern Complement Med. 2016 Dec ;22(12):970-976. Epub 2016 Sep 22. PMID: 27656953 Abstract Author(s): Alexei Wong, Stacey Alvarez-Alvarado, Amber W Kinsey, Arturo Figueroa Article Affiliation: Alexei Wong Abstract: OBJECTIVE: Whole-body vibration (WBV) is an unconventional exercise therapy that appears to provide the same benefits of resistance training in postmenopausal women while being more safe and gentle on the joints. This study evaluated the effect of an 8-week WBV exercise regimen on heart rate variability (HRV) and blood pressure (BP) in obese postmenopausal women. DESIGN: Randomized controlled study with two parallel groups. PARTICIPANTS: Twenty-five (age 50-65 years) obese (body-mass index>30 and<40 kg/m(2)) postmenopausal women. INTERVENTION: Participants were randomly assigned to a WBV training group or nonexercising control group. Participants in the WBV group completed the supervised training 3 times a week. WBV training consisted of four static and four dynamic leg exercises (normal, high, and wide-stance squats and calf-raises) with vertical vibration (25-40 Hz and low-high amplitude) progressed throughout the 8 weeks. OUTCOME MEASURES: Brachial systolic BP (SBP) and diastolic BP (DBP) and HRV: sympathovagal balance (natural logarithm of low frequency [LnLF]/natural logarithm of high frequency [LnHF]; normalized low frequency [nLF]/normalized high frequency [nHF]), parasympathetic tone (LnHF, nHF, natural logarithm of root mean square of successive differences [LnRMSSD]), sympathetic tone (LnLF, nLF), natural logarithm of total power, and heart rate (HR). RESULTS: There were significant group × time interactions (p < 0.05) for brachial SBP, DBP, LnLF/LnHF, and nLF/nHF that significantly decreased (p < 0.01) after WBV, compared with no changes after control. There was a significant (p < 0.05) increase in nHF and decrease in nLF in the WBV group compared with baseline, yet the changes were not different than those in the control group. No significant changes were observed in LnTP, LnLF, LnHF, LnRMSSD, or HR after 8 weeks in either group. CONCLUSIONS: WBV training for 8 weeks is an adequate unconventional exercise intervention for improving sympathovagal balance and BP in previously sedentary obese postmenopausal women. Article Published Date : Nov 30, 2016

Abstract Title: Stochastic resonance whole body vibration increases perceived muscle relaxation but not cardiovascular activation: A randomized controlled trial. Abstract Source: World J Orthop. 2016 Nov 18 ;7(11):758-765. Epub 2016 Nov 18. PMID: 27900274 Abstract Author(s): Achim Elfering, Christian Burger, Volker Schade, Lorenz Radlinger Article Affiliation: Achim Elfering Abstract: AIM: To investigate the acute effects of stochastic resonance whole body vibration (SR-WBV), including muscle relaxation and cardiovascular activation. METHODS: Sixty-four healthy students participated. The participants were randomly assigned to sham SR-WBV training at a low intensity (1.5 Hz) or a verum SR-WBV training at a higher intensity (5 Hz). Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and self-reported muscle relaxation were assessed before and immediately after SR-WBV. RESULTS: Two factorial analyses of variance (ANOVA) showed a significant interaction between pre- vs post-SR-WBV measurements and SR-WBV conditions for muscle relaxation in the neck and back [F(1,55) = 3.35, P = 0.048,η(2) = 0.07]. Muscle relaxation in the neck and back increased in verum SR-WBV, but not in sham SR-WBV. No significant changes between pre- and post-training levels of SBD, DBD and HR were observed either in sham or verum SR-WBV conditions. With verum SR-WBV, improved muscle relaxation was the mostsignificant in participants who reported the experience of back, neck or shoulder pain more than once a month (P<0.05). CONCLUSION: A single session of SR-WBV increased muscle relaxation in young healthy individuals, while cardiovascular load was low. An increase in musculoskeletal relaxation in the neck and back is a potential mediator of pain reduction in preventive worksite SR-WBV trials. Article Published Date : Nov 17, 2016

Abstract Title: [Effect of mechanical vibration on transcutaneous oxygen levels in the feet of type 2 diabetes mellitus patients]. Abstract Source: Med Clin (Barc). 2016 Nov 18. Epub 2016 Nov 18. PMID: 27871769 Abstract Author(s): Gerardo Rodríguez Reyes, Lidia Núñez Carrera, Aldo Alessi Montero, Adriana Solís Vivanco, Ivett Quiñones Uriostegui, Alberto Isaac Pérez Sanpablo Article Affiliation: Gerardo Rodríguez Reyes Abstract: BACKGROUND AND OBJECTIVE: Foot conditions in patients with diabetes mellitus (DM) are major causes of morbidity and disability. Whole body vibration may promote blood circulation in the lower limbs, hence facilitating perfusion and promoting the supply of nutrients and oxygen to comprised tissues. Transcutaneous oxygen levels (TcPO2)>40mmHg in cases of diabetic foot syndrome are associated with a good prognosis in the resolution of ulcers. The objective of this study was to determine whether whole body vibration favors some parameters of interest related to complications associated with the diabetic foot syndrome. PATIENTS AND METHODS: Fifty-four patients with DM were included in a 12-week exercise program based on whole body vibration. Glycemic control was determined on the basis of the patients' levels of glycated hemoglobin (HbA1c); sensitivity and TcPO2 levels of each foot were also recorded. Assessments were performed prior to initiating the whole body vibration program and at the end of it. RESULTS: No significant changes were observed in the patients' HbA1c (P=.442) levels or sensitivity (P=.07). A significant 7mmHg increase (P<.0001; effect size: d=0.53) was observed in the concentration of TcPO2. CONCLUSIONS: Whole body vibration may increase TcPO2 levels with useful implications for the prevention or management of complications associated with restricted blood perfusion in the diabetic foot syndrome. Article Published Date : Nov 17, 2016

Abstract Title: The effects of visual control whole body vibration exercise on balance and gait function of stroke patients. Abstract Source: J Phys Ther Sci. 2016 Nov ;28(11):3149-3152. Epub 2016 Nov 29. PMID: 27942138 Abstract Author(s): Eon-Tak Choi, Yong-Nam Kim, Woon-Soo Cho, Dong-Kyu Lee Article Affiliation: Eon-Tak Choi Abstract: [Purpose] This study aims to verify the effects of visual control whole body vibration exercise on balance and gait function of stroke patients. [Subjects and Methods] A total of 22 stroke patients were randomly assigned to two groups; 11 to the experimental group and 11 to the control group. Both groups received 30 minutes of Neuro-developmental treatment 5 times per week for 4 weeks. The experimental group additionally performed 10 minutes of visual control whole body vibration exercise 5 times per week during the 4 weeks. Balance was measured using the Functional Reach Test. Gait was measured using the Timed Up and Go Test. [Results] An in-group comparison in the experimental group showed significant differences in the Functional Reach Test and Timed Up and Go Test. In comparing the groups, the Functional Reach Test and Timed Up and Go Test of the experimental group were more significantly different compared to the control group. [Conclusion] These results suggest that visual control whole body vibration exercise has a positive effect on the balance and gait function of stroke patients. Article Published Date : Oct 31, 2016

Abstract Title: Does Whole-Body Vibration Improve the Functional Exercise Capacity of Subjects With COPD? A Meta-Analysis. Abstract Source: Respir Care. 2016 Sep 20. Epub 2016 Sep 20. PMID: 27651524 Abstract Author(s): Adriane B Cardim, Patrícia Em Marinho, Jasiel F Nascimento, Helen Kb Fuzari, Armèle Dornelas de Andrade Article Affiliation: Adriane B Cardim Abstract: Whole-body vibration (WBV) is considered a type of physical activity based on the assumption that it results in an increase in muscle strength and performance and, therefore, may be a promising way to exercise patients with COPD. A comprehensive database search (PubMed/MEDLINE, LILACS, CINAHL, Web of Science, Scopus, and COCHRANE Library) for randomized trials, including original articles, that compared WBV groups versus control groups was conducted and studies were selected for comparison. The effect of WBV treatment was compared for minimum clinically important differences. The statistical heterogeneity among the studies was assessed using the I(2) statistic; the results are expressed as percentages. Inconsistencies of up to 25% were considered low, those between 50 and 75% were considerate moderate, and those>75% were considered high. Risk of bias was classified based on the Cochrane Collaboration tool, the meta-analysis was conducted using RevMan 5.3 software, and the level of evidence was assessed using the GRADE system. The primary outcome was functional exercise capacity. Secondary outcomes were quality of life, performance in activities of daily living, muscle strength of the lower limbs, and possible adverse effects assessed clinically or by subject reports. We included 4 articles involving 185 subjects for analysis. All subjects in the groups undergoing WBV showed improvement in distance walked in the 6-min walk test compared with the control group (57.85 m, 95% CI 16.36-99.33 m). Regarding the secondary end points, just one article reported improved quality of life and activities of daily living. The only article that assessed muscle strength found no difference between the groups. The quality of evidence for functional exercise capacity outcome was considered moderate. WBV seems to benefit subjects with COPD by improving their functional exercise capacity, without producing adverse effects. The quality of evidence is moderate, but the degree of recommendation is strong. Article Published Date : Sep 19, 2016

Abstract Title: Effects of whole body vibration exercises on bone mineral density of women with postmenopausal osteoporosis without medications: novel findings and literature review. Abstract Source: J Musculoskelet Neuronal Interact. 2016 Sep 7 ;16(3):193-203. Epub 2016 Sep 7. PMID: 27609034 Abstract Author(s): C F Dionello, D Sá-Caputo, H Vfs Pereira, C R Sousa-Gonçalves, A I Maiworm, D S Morel, E Moreira-Marconi, L L Paineiras-Domingos, D Bemben, M Bernardo-Filho Article Affiliation: C F Dionello Abstract: OBJECTIVES: The aim of this study was to review the literature about the effect of whole body vibration exercise in the BMD in patients with postmenopausal osteoporosis without medications. METHODS: A systematic review was performed. RESULTS: The frequency of the mechanical vibration used in the protocols has varied from 12 to 90 Hz. The time used in the protocols varied from 2 up to 22 months. Techniques with X-rays were used in nine of the twelve publications analyzed, the Dual energy X-ray absorptiometry (DEXA) in eight studies and the High resolution peripheral quantitative computed tomography (HR-pQCT) in one publication. The concentration of some biomarkers was determined, as the sclerostin, the bone alkaline phosphatase, N-telopeptide X and 25-hydroxyvitamin D. Among the twelve articles analyzed, seven of them have shown an improvement of the BMD of some bone of postmenopausal women exposed to whole body vibration exercises not associated to medications; as well as modifications in biomarkers. Article Published Date : Sep 06, 2016

Abstract Title: Role of the Whole Body Vibration Machine in the Prevention and Management of Osteoporosis in Old Age: A Systematic Review. Abstract Source: Malays J Med Sci. 2016 Sep ;23(5):8-16. Epub 2016 Oct 5. PMID: 27904420 Abstract Author(s): Myint Swe, Biju Benjamin, Aye Aye Tun, Sandheep Sugathan Article Affiliation: Myint Swe Abstract: A literature search of related articles was carried out in electronic data sources. Initially, 276 randomised controlled trials related to the title were collected, after which 44 were selected using the keywords. Overlapping articles, articles with a study duration of less than six months, and studies involving young participants were removed from the list. The remaining 20 articles were checked for entitlement using the PEDro scale. A total of nine eligible articles with 1486 participants were analysed. Seven trials used dual-energy x-ray absorptiometry (DXA) to measure bone mineral density (BMD). The six trials published from 2005 to 2013 found a significant increase in BMD. In the remaining one trial, there was no significant increase in BMD. One study published in 2013 reported a significant increase in BMD measured with peripheral qualitative computed tomography, whereas another trial published in 2014 stated that there was a reduction in calcaneal bone density measured by peripheral qualitative ultrasound. From these findings it can be concluded that the whole body vibration machine is a good adjunctive therapy for the prevention and management of osteoporosis in postmenopausal women. However, further investigations are necessary before the same can be recommended for elderly men. Article Published Date : Aug 31, 2016

Abstract Title: Optimal frequency/time combination of whole-body vibration training for improving muscle size and strength of people with age-related muscle loss (sarcopenia): A randomized controlled trial. Abstract Source: Geriatr Gerontol Int. 2016 Aug 31. Epub 2016 Aug 31. PMID: 27578535 Abstract Author(s): Ning Wei, Marco Yc Pang, Shamay Sm Ng, Gabriel Yf Ng Article Affiliation: Ning Wei Abstract: AIM: To determine the optimal combination of frequency and exposure time of a whole-body vibration (WBV) training program for improving muscle performance of older people with age-related muscle loss. METHODS: A total of 80 community-dwelling older adults with age-related muscle loss were randomly divided into four equal groups, namely, low-frequency long duration (20 Hz × 720 s), medium-frequency medium duration (40 Hz × 360 s), high-frequency short duration (60 Hz × 240 s) and control (no training) for 12-week WBV training and 12-week follow up. Assessments were carried out at baseline, mid-intervention, post-intervention, mid-followup, follow up for the cross-sectional area of the vastus medialis, isometric knee extension strength at 90°, and isokinetic knee extension at 60°/s and 180°/s. RESULTS: There was a significant time × group interaction effect in isokinetic knee extension at 180°/s. Significant time effects were found in all muscle strength outcome variables. Group differences in percentage change from baseline were significant between medium-frequency medium duration and control on isokinetic knee extension at 180°/s and 60°/s. No changes were found in the cross-sectional area of the vastus medialis. CONCLUSIONS: With the total number of vibrations controlled, the combination of 40 Hz and 360 s of WBV exercise had the best outcome among all other combinations tested. The improvements in knee extension performance can be maintained for 12 weeks after cessation of WBV training. Geriatr Gerontol Int 2016; ••: ••-••. Article Published Date : Aug 30, 2016

Abstract Title: The effects of long-term whole-body vibration and aerobic exercise on body composition and bone mineral density in obese middle-aged women. Abstract Source: J Exerc Nutrition Biochem. 2016 Jun ;20(2):19-27. Epub 2016 Jun 30. PMID: 27508150 Abstract Author(s): Sang-Seok Nam, Sub Sunoo, Hun-Young Park, Hwang-Woon Moon Article Affiliation: Sang-Seok Nam Abstract: PURPOSE: The purpose of this study was to determine the effectiveness of whole-body passive vibration exercise and its differences from aerobic exercise on body composition, bone mineral density (BMD) and bone mineral content (BMC). METHODS: Obese middle-aged women (n=33 out of 45) with 34±3% body fat completed the training protocol. They were randomly assigned into diet (n=9; control group), diet plus whole-body vibration exercise (n=13; vibration group), and diet plus aerobic exercise (n=11; aerobic group) groups and we compared their body composition, BMD, and BMC before and after 9 months of training. There were no significant differences in nutrient intake among groups during the training period. RESULTS: Relative body fat (%) decreased significantly (p<.05) in all three groups and the exercise groups showed a greater reduction in fat mass than the diet only group. BMD in the whole body, lumbar spine, hip and forearm were not significantly different among the three groups. Total body BMC increased significantly in the vibration group throughout the first 6 months of training. CONCLUSION: Results suggest that long- term vibration training when used in conjunction with a diet program is as effective as aerobic exercise with a diet program in improving body composition of obese middle-aged women without compromising BMC or BMD. Thus, it can be considered a novel and effective method for reducing body fat. Article Published Date : May 31, 2016

Abstract Title: Whole Body Vibration Treatments in Postmenopausal Women Can Improve Bone Mineral Density: Results of a Stimulus Focussed Meta-Analysis. Abstract Source: PLoS One. 2016 ;11(12):e0166774. Epub 2016 Dec 1. PMID: 27907000 Abstract Author(s): Antonio Fratini, Tecla Bonci, Anthony M J Bull Article Affiliation: Antonio Fratini Abstract: Whole body vibration treatment is a non-pharmacological intervention intended to stimulate muscular response and increase bone mineral density, particularly for postmenopausal women. The literature related to this topic is controversial, heterogeneous, and unclear despite the prospect of a major clinical effect.The aim of this study was to identify and systematically review the literature to assess the effect of whole body vibration treatments on bone mineral density (BMD) in postmenopausal women with a specific focus on the experimental factors that influence the stimulus. Nine studies fulfilled the inclusion criteria, including 527 postmenopausal women and different vibration delivery designs. Cumulative dose, amplitudes and frequency of treatments as well as subject posture during treatment vary widely among studies. Some of the studies included an associated exercise training regime. Both randomized and controlled clinical trials were included. Whole body vibration was shown to produce significant BMD improvements on the hip and spine when compared to no intervention. Conversely, treatment associated with exercise training resulted in negligible outcomes when compared to exercise training or to placebo. Moreover, side-alternating platforms were more effective in improving BMD values than synchronous platforms and mechanical oscillations of magnitude higher than 3 g and/or frequency lower than 25 Hz were also found to be effective. Treatments with a cumulative dose over 1000 minutes in the follow-up period were correlated to positive outcomes.Our conclusion is that whole body vibration treatments in elderly women can reduce BMD decline.However, many factors (e.g., amplitude, frequency and subject posture) affect the capacity of the vibrations to propagate to the target site; the adequate level of stimulation required to produce these effects has not yet been defined. Further biomechanical analyses to predict the propagation of the vibration waves along the body and assess the stimulation levels are required. Article Published Date : Dec 31, 2015

Abstract Title: Effects of Three Weeks of Whole-Body Vibration Training on Joint-Position Sense, Balance, and Gait in Children with Cerebral Palsy: A Randomized Controlled Study. Abstract Source: Physiother Can. 2016 ;68(2):99-105. PMID: 27909356 Abstract Author(s): Myung-Sook Ko, Yon Ju Sim, Do Hyun Kim, Hye-Seon Jeon Article Affiliation: Myung-Sook Ko Abstract: Purpose : To observe the effects of whole-body vibration (WBV) training in conjunction with conventional physical therapy (PT) on joint-position sense (JPS), balance, and gait in children with cerebral palsy (CP). Methods: In this randomized controlled study, 24 children with CP were randomly selected either to continue their conventional PT or to receive WBV in conjunction with their conventional PT programme. Exposure to the intervention was intermittent (3 min WBV, 3 min rest) for 20 minutes, twice weekly for 3 weeks. JPS, balance, and gait were evaluated before and after treatment. Results: Ankle JPS was improved after 3 weeks of WBV training (p=0.014). Participants in the WBV group showed greater improvements in speed (F1,21=5.221, p=0.035) and step width (F1,21=4.487, p=0.039) than participants in the conventional PT group. Conclusion: Three weeks of WBV training was effective in improving ankle JPS and gait variables in children with CP. Article Published Date : Dec 31, 2015

Abstract Title: Whole-body vibration training decreases ankle systolic blood pressure and leg arterial stiffness in obese postmenopausal women with high blood pressure. Abstract Source: Menopause. 2015 Apr ;22(4):423-7. PMID: 25225715 Abstract Author(s): Arturo Figueroa, Roy Kalfon, Alexei Wong Article Affiliation: Arturo Figueroa Abstract: OBJECTIVE: High ankle systolic blood pressure (SBP;≥175 mm Hg) is associated with arterial stiffness (pulse wave velocity [PWV]) and cardiac events. This study aims to investigate the effects of whole-body vibration (WBV) training on ankle SBP and its associations with changes in PWV and aortic SBP in postmenopausal women. METHODS: Thirty-six postmenopausal women were randomized to a control group (n = 12) or a WBV training group (3 d/wk) that was stratified by ankle SBP into WBV-high (n = 12) and WBV-normal (n = 12). Ankle SBP, brachial SBP, aortic SBP, femoral-ankle PWV (legPWV), carotid-femoral PWV, and brachial-ankle PWV (baPWV) were examined before and after 12 weeks. RESULTS: Baseline ankle SBP was higher (P<0.05) in the WBV-high group compared with the WBV-normal group. WBV-high reduced mean (SEM) ankle SBP (-24 [7] mm Hg, P<0.05) compared with WBV-normal and control. Both WBV groups decreased (P<0.05) mean (SEM) brachial SBP (-11 [2] mm Hg), aortic SBP (-11 [3] mm Hg), legPWV (-0.80 [0.17] m/s), and baPWV (-1.18 [0.27] m/s) compared with the control group. Reductions in legPWV were correlated (P<0.05) with decreases in ankle SBP (r = 0.43), brachial SBP (r = 0.42), aortic SBP (r = 0.42), and baPWV (r = 0.75). CONCLUSIONS: WBV training decreases ankle SBP in postmenopausal women with high ankle SBP. WBV training reduces aortic SBP, legPWV, and baPWV, but not carotid-femoral PWV, in postmenopausal women independently of ankle SBP. Therefore, reductions in peripheral and central SBP induced by WBV training are explained by a reduction in peripheral PWV. Article Published Date : Mar 31, 2015