×

Message

EU e-Privacy Directive

This website uses cookies to manage authentication, navigation, and other functions. By using our website, you agree that we can place these types of cookies on your device.

View e-Privacy Directive Documents

You have declined cookies. This decision can be reversed.

Dietary Modification - Mediterranean Diet

Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population📎

Written by CYBERMED LIFE NEWS
Attachments:
Download this file (Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population..pdf)Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population..pdf[Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population.]517 kB
Abstract Title:

Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population.

Abstract Source:

Genes Nutr. 2015 Sep ;10(5):480. Epub 2015 Jul 17. PMID: 26183162

Abstract Author(s):

Antonella Agodi, Martina Barchitta, Annalisa Quattrocchi, Andrea Maugeri, Carolina Canto, Anna Elisa Marchese, Manlio Vinciguerra

Article Affiliation:

Antonella Agodi

Abstract:

Several dietary agents, such as micronutrient and non-nutrient components, the so-called bioactive food components, have been shown to display anticancer properties and influence genetic processes. The most common epigenetic change is DNA methylation. Hypomethylation of long interspersed elements (LINE-1) has been associated with an increased risk of several cancers, although conflicting findings have also been observed. The aim of the present study was to test the hypothesis that a low adherence to the Mediterranean diet (MD) and folate deficiency may cause LINE-1 hypomethylation in blood leukocytes of healthy women, and thus genomic instability. One hundred and seventy-seven non-pregnant women were enrolled. Mediterranean diet score (MDS) and folate intake were calculated using a food frequency questionnaire. LINE-1 methylation level was measured by pyrosequencing analysis in three CpG sites of LINE-1 promoter. According to MDS, only 9.6 % of subjects achieved a high adherence to MD. Taking into account the use of supplements, there was a high prevalence of folate deficiency (73.4 %). Women whose consumption of fruit was below the median value (i.e.,<201 gr/day) were 3.7 times more likely to display LINE-1 hypomethylation than women whose consumption was above the median value (OR 3.7; 95 % CI 1.4-9.5). Similarly, women with folate deficiency were 3.6 times more likely to display LINE-1 hypomethylation than women with no folate deficiency (OR 3.6; 95 % CI 1.1-12.1). A dietary pattern characterized by low fruit consumption and folate deficiency is associated with LINE-1 hypomethylation and with cancer risk.