CYBERMED LIFE - ORGANIC  & NATURAL LIVING

Dietary Modification - Low Carbohydrate-Ketogenic

Control of seizures by ketogenic diet-induced modulation of metabolic pathways.

Written by CYBERMED LIFE NEWS
facebook Share on Facebook
Abstract Title:

Control of seizures by ketogenic diet-induced modulation of metabolic pathways.

Abstract Source:

Amino Acids. 2016 Sep 28. Epub 2016 Sep 28. PMID: 27683025

Abstract Author(s):

Ryan M Clanton, Guoyao Wu, Gamal Akabani, Rodolfo Aramayo

Article Affiliation:

Ryan M Clanton

Abstract:

Epilepsy is too complex to be considered as a disease; it is more of a syndrome, characterized by seizures, which can be caused by a diverse array of afflictions. As such, drug interventions that target a single biological pathway will only help the specific individuals where that drug's mechanism of action is relevant to their disorder. Most likely, this will not alleviate all forms of epilepsy nor the potential biological pathways causing the seizures, such as glucose/amino acid transport, mitochondrial dysfunction, or neuronal myelination. Considering our current inability to test every individual effectively for the true causes of their epilepsy and the alarming number of misdiagnoses observed, we propose the use of the ketogenic diet (KD) as an effective and efficient preliminary/long-term treatment. The KD mimics fasting by altering substrate metabolism from carbohydrates to fatty acids and ketone bodies (KBs). Here, we underscore the need to understand the underlying cellular mechanisms governing the KD's modulation of various forms of epilepsy and how a diverse array of metabolites including soluble fibers, specific fatty acids, and functional amino acids (e.g., leucine, D-serine, glycine, arginine metabolites, and N-acetyl-cysteine) may potentially enhance the KD's ability to treat and reverse, not mask, these neurological disorders that lead to epilepsy.


We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.