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Structured physical exercise improves neuropsychiatric symptoms in acute dementia care: a hospital-based RCT.
Alzheimers Res Ther. 2017 Aug 29 ;9(1):68. Epub 2017 Aug 29. PMID: 28851451
Tim Fleiner
BACKGROUND: The primary objective of this trial is to investigate the effects of a short-term exercise program on neuropsychiatric signs and symptoms in acute hospital dementia care.
METHODS: Within a hospital-based randomized controlled trial, the intervention group conducted a 2-week exercise program with four 20-min exercise sessions on 3 days per week. The control group conducted a social stimulation program. Effects on neuropsychiatric signs and symptoms were measured via the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change, the Neuropsychiatric Inventory, and the Cohen-Mansfield Agitation Inventory. Theantipsychotic and sedative dosage was quantified by olanzapine and diazepam equivalents.
RESULTS: Eighty-five patients were randomized via minimization to an intervention group (IG) and a control group (CG). Seventy patients (82%) (mean age 80 years, 33 females, mean Mini Mental State Examination score 18.3 points) completed the trial. As compared to the CG (n = 35), the IG (n = 35) showed significantly reduced neuropsychiatric signs and symptoms. Especially, agitated behavior and lability improved. There were no between-group differences concerning antipsychotic and benzodiazepine medication.
CONCLUSIONS: This exercise program is easily applicable in hospital dementia care and significantly reduces neuropsychiatric signs and symptoms in patients suffering from predominantly moderate stages of dementia.
TRIAL REGISTRATION: German Clinical Trial Register DRKS00006740 . Registered 28 October 2014.
