CYBERMED LIFE - ORGANIC  & NATURAL LIVING

Laser Treatment - Low-Level

Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits. 📎

Written by CYBERMED LIFE NEWS
Attachments:
Download this file (Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits..pdf)Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits..pdf[Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits.]925 kB
facebook Share on Facebook
Abstract Title:

Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits.

Abstract Source:

Stroke. 2006 Oct;37(10):2620-4. Epub 2006 Aug 31. PMID: 16946145

Abstract Author(s):

Amir Oron, Uri Oron, Jieli Chen, Anda Eilam, Chunling Zhang, Menachem Sadeh, Yair Lampl, Jackson Streeter, Luis DeTaboada, Michael Chopp

Article Affiliation:

Department of Orthopedics, Assaf Harofeh Medical Center, Zerifin 70300, Israel. This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract:

BACKGROUND AND PURPOSE: Low-level laser therapy (LLLT) modulates various biological processes. In the present study, we assessed the hypothesis that LLLT after induction of stroke may have a beneficial effect on ischemic brain tissue.

METHODS: Two sets of experiments were performed. Stroke was induced in rats by (1) permanent occlusion of the middle cerebral artery through a craniotomy or (2) insertion of a filament. After induction of stroke, a battery of neurological and functional tests (neurological score, adhesive removal) was performed. Four and 24 hours poststroke, a Ga-As diode laser was used transcranially to illuminate the hemisphere contralateral to the stroke at a power density of 7.5 mW/cm2.

RESULTS: In both models of stroke, LLLT significantly reduced neurological deficits when applied 24 hours poststroke. Application of the laser at 4 hours poststroke did not affect the neurological outcome of the stroke-induced rats as compared with controls. There was no statistically significant difference in the stroke lesion area between control and laser-irradiated rats. The number of newly formed neuronal cells, assessed by double immunoreactivity to bromodeoxyuridine and tubulin isotype III as well as migrating cells (doublecortin immunoactivity), was significantly elevated in the subventricular zone of the hemisphere ipsilateral to the induction of stroke when treated by LLLT.

CONCLUSIONS: Our data suggest that a noninvasive intervention of LLLT issued 24 hours after acute stroke may provide a significant functional benefit with an underlying mechanism possibly being induction of neurogenesis.


We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.