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Neurominidase Inhibitor

Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.

Written by CYBERMED LIFE NEWS
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Abstract Title:

Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.

Abstract Source:

Bioorg Med Chem Lett. 2015 Aug 15 ;25(16):3256-60. Epub 2015 May 31. PMID: 26077494

Abstract Author(s):

Byung Soon Hwang, In-Kyoung Lee, Hwa Jung Choi, Bong-Sik Yun

Article Affiliation:

Byung Soon Hwang

Abstract:

Five polyphenols were isolated from the ethanolic extract of the fruiting bodies of Phellinus baumii. These compounds were identified by various spectroscopic methods as hispidin, hypholomine B, inoscavin A, davallialactone, and phelligridin D. All compounds inhibited noncompetitively H1N1, H5N1, and H3N2 neuraminidase activity and reduced the amount of virally-induced cytopathic effect (CPE) according to an MDCK cell-based assay.

Article Published Date : Aug 14, 2015
Category: Micotherapy
Polyphenols, H3N2 Infection, H5N1 Infection, Influenza A, Neurominidase Inhibitor, Medicinal Mushrooms, Mushrooms: All, In Vitro Study, Micotherapy