High-fat and ketogenic diets in amyotrophic lateral sclerosis.
J Child Neurol. 2013 Aug ;28(8):989-92. Epub 2013 May 10. PMID: 23666040
Sabrina Paganoni, Anne-Marie Wills
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease. Epidemiologic data suggest that malnutrition is a common feature in amyotrophic lateral sclerosis and being overweight or obese confers a survival advantage in this patient population. In amyotrophic lateral sclerosis mouse models, a high-fat diet has been shown to lead to weight gain and prolonged survival. However, little research has been conducted to test whether nutritional interventions might ameliorate the disease course in humans. Here we review the currently available evidence supporting the potential role of dietary interventions as a therapeutic tool for amyotrophic lateral sclerosis. Ultimately, determining whether a high-fat or ketogenic diet could be beneficial in amyotrophic lateral sclerosis will require large randomized, placebo-controlled clinical trials.
Article Published Date : Jul 31, 2013
Dietary treatment of diabetes mellitus in the pre-insulin era (1914-1922).
Perspect Biol Med. 2006;49(1):77-83. PMID: 16489278
[No authors listed]
Before the discovery of insulin, one of the most common dietary treatments of diabetes mellitus was a high-fat, low-carbohydrate diet. A review of Frederick M. Allen's case histories shows that a 70% fat, 8% carbohydrate diet could eliminate glycosuria among hospitalized patients. A reconsideration of the role of the high-fat, low-carbohydrate diet for the treatment of diabetes mellitus is in order.
Article Published Date : Jan 01, 2006