Cybermedlife - Therapeutic Actions Dietary Modification - Low Carbohydrate-High Protein

The effects of high-protein, low-carbohydrate diet on body weight and the expression of gastrointestinal hormones in diet-induced obesity rat

Abstract Title: [The effects of high-protein, low-carbohydrate diet on body weight and the expression of gastrointestinal hormones in diet-induced obesity rat]. Abstract Source: Zhonghua Yu Fang Yi Xue Za Zhi. 2011 Feb;45(2):132-5. PMID: 21426792 Abstract Author(s): Hai-yan Chen, Li-chuan Ma, Yin-yin Li, Jia-jun Zhao, Ming-long Li Article Affiliation: Department of Health-Care Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China. Abstract: OBJECTIVE: To investigate the effects of long-term high-protein, low-carbohydrate diet on body weight and the expression of gastrointestinal hormones in diet-induced obesity rats. METHODS: Twenty-four diet-induced obesity rat models were established by feeding fat-enriched diet, then were randomly divided into two groups by stratified sampling method by weight: the high-protein diet group (HP, 36.7% of energy from protein), and the normal chow group (NC, 22.4% of energy from protein), 12 rats in each group. The total calorie intake of each rat per day was similar and was maintained for 24 weeks, then body weight, visceral fat mass, fasting plasma ghrelin and glucagon-like peptide-1 (GLP-1) were determined, as well as protein expression of ghrelin in stomach, GLP-1 in ileum were detected by immunohistochemistry. RESULTS: After 24 weeks, body weight of HP, NC groups were (490.92± 39.47) g and (545.55 ± 31.08) g, respectively (t = -3.664, P<0.01); visceral fat mass were (22.42± 7.04) g and (32.33 ± 9.27) g, respectively (t = -2.503, P<0.05); plasma ghrelin level were (2.36± 0.82) and (1.95 ± 0.64) ng/ml, respectively (t = 1.337, P>0.05), and plasma ghrelin level was negatively correlated to body weight (r = -0.370, t = -1.899, P<0.05), visceral fat mass (r = -0.454, t = -2.52, P<0.01); plasma GLP-1 concentration were (0.52± 0.13) and (0.71 ± 0.19) ng/ml, respectively(t = -2.758, P<0.05); ghrelin protein expression in stomach were 25 473± 8701 and 10 526 ± 6194, respectively (t = 2.501, P<0.05); GLP-1 protein expression in ileum were 27 431± 5813 and 36 601 ± 5083, respectively (t = -1.833, P = 0.081). CONCLUSION: Long-term isocaloric high-protein, low-carbohydrate diet can reduce body weight and visceral fat, increase the expression of ghrelin, and decline GLP-1 expression in diet-induced obesity rats. Article Published Date : Feb 01, 2011
Therapeutic Actions DIETARY MODIFICATION Low Carbohydrate-High Protein

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Suppression of Postprandial Blood Glucose Fluctuations by a Low-Carbohydrate, High-Protein, and High-Omega-3 Diet via Inhibition of Gluconeogenesis.

Related Articles Suppression of Postprandial Blood Glucose Fluctuations by a Low-Carbohydrate, High-Protein, and High-Omega-3 Diet via Inhibition of Gluconeogenesis. Int J Mol Sci. 2018 Jun 21;19(7): Authors: Wang B, Smyl C, Chen CY, Li XY, Huang W, Zhang HM, Pai VJ, Kang JX Abstract Hyperglycemia significantly contributes to the development and progression of metabolic diseases. Managing postprandial blood glucose fluctuations is of particular importance for patients with hyperglycemia, but safe and effective means of reducing blood glucose levels are still lacking. Five diets with varying macronutrient ratios and omega-3 fatty acid amounts were tested for their blood glucose-lowering effects in male C57BL/6J mice. The diets with potent blood glucose-lowering effects were further investigated for their underlying mechanisms and their beneficial effects on hyperglycemia models. Mice given the low-carbohydrate, high-protein, and high-omega-3 (LCHP+3) diet exhibited a rapid reduction of the blood glucose levels that remained consistently low, regardless of feeding. These effects were associated with reduced amino acid gluconeogenesis, due to the inhibition of hepatic alanine transaminase (ALT). Furthermore, the LCHP+3 intervention was effective in reducing the blood glucose levels in several disease conditions, including type 1 diabetes mellitus, hormone-induced hyperglycemia, and diet-induced metabolic syndrome. Our findings identify the LCHP+3 diet as a potent blood glucose-lowering diet that suppresses postprandial blood glucose fluctuations through the inhibition of gluconeogenesis and may have great clinical utility for the management of metabolic diseases with hyperglycemia. PMID: 29933567 [PubMed - indexed for MEDLINE]