Cybermedlife - Therapeutic Actions Electrotherapy

Assessment of the Effects of Extremely Low Frequency Electromagnetic Fields on Toxoplasma gondii. 📎

Abstract Title: Assessment of the Effects of Extremely Low Frequency Electromagnetic Fields on Toxoplasma gondii. Abstract Source: Iran J Parasitol. 2016 Apr-Jun;11(2):159-167. PMID: 28096849 Abstract Author(s): Sercin Ozlem-Caliskan, Hatice Ertabaklar, Mehmet Dincer Bilgin, Sema Ertug Article Affiliation: Sercin Ozlem-Caliskan Abstract: BACKGROUND: The effects of extremely low frequency electromagnetic fields (ELF-EMF) on Toxoplasma gondii have not been explained yet. The aim of this study was to assess the possible effects of ELF-EMF on growth, survival time and viability of Toxoplasma gondii. In addition, the life span of Toxoplasma infected animals was investigated. METHODS: Sixty adult male BALB/c mice were used for in vivo and in vivo experiments in Laboratory of Biopyhsics and Parasitology of Medical Faculty, Adnan Menderes University, Turkey, in 2010. During in vivo experiments, pulsed and continuous EMFs were applied for 5 d to the infected mice. During in vivo experiments, pulsed and continuous EMF was applied to the tachyzoites within peritoneal exudates for 8 h/d at 4°C and the tachyzoites were then injected to mice. In both experiments, the number of T. gondii in peritoneal exudates was counted and T. gondii protein bands patterns were investigated with polyacrylamide gel electrophoresis and Western Blotting. RESULTS: Pulsed and continuous EMF exposure reduced the number of T. gondii tachyzoites in comparison to controls. However, no statistically significant differences were observed at the patterns of protein bands among the samples. CONCLUSION: EMF exposure induces a decrease in the number of T. gondii. Further studies are required to understand the mechanism of EMF on intracellular parasites. Article Published Date : Mar 31, 2016

A clinical study of acupuncture and SSP (silver spike point) electro-therapy for dry eye syndrome.

Abstract Title: A clinical study of acupuncture and SSP (silver spike point) electro-therapy for dry eye syndrome. Abstract Source: Am J Chin Med. 2006;34(2):197-206. PMID: 16552832 Abstract Author(s): Kuo-Lieh Tseng, Hsu-Jan Liu, Kam-Yuen Tso, Lin-Chung Woung, Yi-Chang Su, Jaung-Geng Lin Article Affiliation: Graduate Institute of Integration Chinese and Western Medicine, China Medical University, Taichung, Taiwan. Abstract: The present study was designed as a clinical trial to assess the efficacy of acupuncture and silver spike point (SSP) electro-therapy on dry eye syndrome. A total of 43 dry eye syndrome patients participated in the present study. Subjects were divided into control, acupuncture and SSP electro-therapy groups. The three groups were all given artificial tears treatment. Patients in the treatment groups were given two 20-minute treatments of either acupuncture or SSP. Assessment was carried out using the Basal Schirmer test, tear break-up time (BUT), visual analog scale (VAS) and an overall score of eye condition. After four weeks of treatment, both the acupuncture and SSP treatment groups showed improvements over the control group, in Schirmer tests of the left eye and average tearing of both eyes. After 8 weeks of treatment, both treatment groups showed improvements over the control group both in Schirmer tests and VAS. For the right eye, treatment groups showed significant improvements in Schirmer test and VAS versus the control group averages for both eyes. There was no significant difference in BUT at any time. Comparing scores before and after treatment, the acupuncture and SSP groups showed a significant improvement compared to the control group. The acupuncture group showed a greater 8-week improvement in Schirmer tests scores compared to the SSP group. However, the SSP group patients used fewer applications of artificial tears. Acupuncture and SSP electro-therapy were effective in increasing tear secretion in patients with dry eye syndrome. The SSP electro-therapy not only alleviated dry eye syndrome, but also reduced the number of applications of artificial tears necessary. Article Published Date : Jan 01, 2006
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[Optimal acupoint combination of transcutaneous electrical stimulation in artificial abortion operation].

Related Articles [Optimal acupoint combination of transcutaneous electrical stimulation in artificial abortion operation]. Zhongguo Zhen Jiu. 2017 Feb 12;37(2):175-179 Authors: Chen C, Xie W, Wang Z, Zeng L, Liu P, Li C Abstract OBJECTIVE: To observe the clinical effects on analgesia, tranquilization and prevention of abortion syndrome of artificial abortion operation treated with transcutaneous electrical acupoint stimulation (TEAS) with different acupoint combination and explore the optimal acupoint combination of TEAS in artificial abortion operation. METHODS: Two hundred patients intended to artificial operation were randomized into No.1 group[Sanyinjiao (SP 6) + Zusanli (ST 36)], No.2 group[Sanyinjiao (SP 6) + Diji (SP 8)], No.3 group[Sanyinjiao (SP 6) + Taichong (LR 3)], No.4 group (cervical blockage anesthesia with lidocaine) and No.5 group (blank group, without any analgesia measure applied), 40 cases in each one. In the No.1, No.2 and No.3 groups, Sanyinjiao (SP 6) was the main acupoint, combined with Zusanli (ST 36), Dijin (SP 8) and Taichong (LR 3) respectively. TEAS was given 30 min before the operation till the end of operation. Mean arterial pressure, heart rate and oxygen saturation during operation, as well as bleeding amount were observed in the five groups. The visual analogue scale (VAS) score was observed during and 30 min after operation, and Ramsay score was observed during operation. Cervical relaxation degree and the incidence of artificial abortion syndrome were recorded. RESULTS: For VAS score during and 30 min after operation and Ramsay score during operation, the differences were significant statistically in the No. 1, No.2, No.3 and No.4 groups as compared with the No.5 group (P<0.01, P<0.05). The results in the No.2 group were better than those in the No.1, No.3 and No.4 groups (all P<0.05). For cervical relaxationdegree, the result in the No.2 group was better than that in each of the rest groups (P<0.01, P<0.05). For artificial abortion syndrome, the incidences in the No.2 and No.3 groups were lower than those in the No.4 and No.5 groups (all P<0.05). For bleeding amount and hemodynamic changes, the differences were not significant statistically among the five groups (all P>0.05). CONCLUSIONS: TEAS apparently reduces pain score during and 30 min after artificial abortion operation and achieves the satisfactory tranguilization effects. The combination of Sanyinjiao (SP 6) and Diji (SP 8) achieves the optimal effect of analgesia, tranquilization, dilating cervix and preventing from artificial abortion syndrome in the operation. PMID: 29231482 [PubMed - indexed for MEDLINE]

[Effects of electroacupuncture on synaptic plasticity in hippocampal CA3 area of rats with chronic stress depression].

Related Articles [Effects of electroacupuncture on synaptic plasticity in hippocampal CA3 area of rats with chronic stress depression]. Zhongguo Zhen Jiu. 2017 Feb 12;37(2):162-168 Authors: Wang L, Zhang D, Tian X, Liu D, Sun X, Li Y, Wang C, Ma M, Li D, Sun Z Abstract OBJECTIVE: To explore the effects of electroacupuncture (EA) on behavioral function and synaptic plasticity in hippocampal CA3 area in rats with chronic stress depression. METHODS: According to the random number table method, 144 SD male rats were assigned into a blank group, a model group, an EA group and a fluoxetine group, then each group was divided into a 7 d subgroup, a 14 d subgroup and a 21 d subgroup, 12 rats in each subgroup. The chronic mild unpredictable stress stimulus combined with lonely breeding were applied to establish the depression model of rats, which was performed simultaneously with intervention treatment. The rats in the EA group were treated with EA (dilatational wave) at "Shenting" (GV 24) and "Baihui" (GV 20), while the rats in fluoxetine group were treated with intragastric administration of fluoxetine, once daily. With open-field test, sugar consumption experiment and transmission electron microscope, the changes of behavior and neuronal synapse inhippocampal CA3 area were observed. RESULTS: On 7 d, 14 d and 21 d, compared with the blank group, the open-field test score, sugar consumption and body mass were significantly lower in the model group (all P<0.01); compared with the model group, the open-field test score, sugar consumption and body mass were significantly higher in the EA group and the fluoxetine group on 14 d and 21 d (P<0.01, P<0.05). On 14 d and 21 d, compared with the blank group, the synapse in hippocampal CA3 area was significantly lower in the model group (both P<0.01); compared with the model group, the synapse in hippocampal CA3 area was significantly higher in the EA group and the fluoxetine group (P<0.01, P<0.05). The neurons cells in hippocampal CA3 area in the model group showed pyknosis and deformation from 7 d with fusion structure and unclear boundary of synapse, which were significantly improved on 21 d; the neurons cells in hippocampal CA3 area in the EA group and the fluoxetine group were significantly improved from 14 d and restored to normal level on 21 d, in addition, the structure of synapse restored to normal level. CONCLUSIONS: EA is involved in the regulation of synaptic plasticity in hippocampal CA3 area, and promotes the recovery of depression symptoms. PMID: 29231480 [PubMed - indexed for MEDLINE]

[Effects of electroacupuncture preconditioning on expression of aquaporin-1 and activity of protein kinase C in myocardium of rats with acute myocardial ischemia-reperfusion injury].

Related Articles [Effects of electroacupuncture preconditioning on expression of aquaporin-1 and activity of protein kinase C in myocardium of rats with acute myocardial ischemia-reperfusion injury]. Zhongguo Zhen Jiu. 2017 Feb 12;37(2):157-161 Authors: Cai R, Hu L, Shen G, Yu Q, Wang J, Wu Z, Li M Abstract OBJECTIVE: To explore the partial action mechanism and the myocardial protective effect differences between electroacupuncture (EA) preconditioning at "Neiguan"(PC 6) and "Taiyuan"(LU 9) in rats with acute myocardial ischemia-reperfusion injury. METHODS: Ninety-six Wistar rats were randomly assigned into a sham-operation group, a model group, a Neiguan group and a Taiyuan group, 24 rats in each one. The rats in the Neiguan group and Taiyuan group were treated with EA (2 Hz in frequency, 1 mA in intensity) at "Neiguan" (PC 6) and "Taiyuan" (LU 9) respectively, 20 min per treatment, once a day for consecutive 7 days. The rats in the sham-operation group and model group were treated with immobilization for the same time, and no EA was given. The model of myocardial ischemia-reperfusion injury was established in the model group, Neiguan group and Taiyuan group 24 h after the end of EA, while the rats in the sham-operation group were treated with sham operation (no ligation was made during surgery). The myocardial ischemic size, infarction size, activity of protein kinase C (PKC) and expression of aquaporin1 (AQP1) in each group were detected. RESULTS: Compared with sham-operation group, the myocardial ischemic size, infarction size, AQP1 expression and PKC activity in the model group were significantly increased (all P<0.01); compared with the model group and Taiyuan group, the myocardial ischemic size, infarction size, PKC activity and AQP1 expression were significantly decreased in the Neiguan group (P<0.01, P<0.05). By Pearson correlation analysis, the changes of AQP1 expression were positively correlated with those of PKC activity after EA preconditioning. CONCLUSIONS: EA preconditioning at "Neiguan" (PC 6) could significantly decrease myocardial AQP1 expression and PKC activity in rats with acute myocardial ischemia-reperfusion injuing, but the effect of EA preconditioning at "Taiyuan"(LU 9) is not obvious; its protective effect is likely to be achieved by inhibiting PKC activity and AQP1 expression. PMID: 29231479 [PubMed - indexed for MEDLINE]

[Transcutaneous electrical nerve stimulation at Neiguan(PC 6) and Zusanli(ST 36) for clinical symptoms and life quality of gastroesophageal reflux patients].

Related Articles [Transcutaneous electrical nerve stimulation at Neiguan(PC 6) and Zusanli(ST 36) for clinical symptoms and life quality of gastroesophageal reflux patients]. Zhongguo Zhen Jiu. 2017 Feb 12;37(2):139-142 Authors: Wu L, Lin Z, Lin L, Zhang H, Wang M Abstract OBJECTIVE: To explore the effect of transcutaneous electrical nerve stimulation(TENS) for symptoms,life quality and sleep quality in patients with gastroesophageal reflux disease(GERD). METHODS: A total of 46 GERD patients were randomly assigned into an observation group and a control group,23 cases in each one. The conventional medication and nursing were applied in the two groups. TENS was used at Neiguan(PC 6) and Zusanli(ST 36) in the observation group for 4 weeks,20 min a time,twice a day. The indexes were compared between the two groups before and after treatment,including reflux disease questionnaire,the MOS 36-item short-form,Pittsburgh sleep quality index(PSQI). RESULTS: Except the factor score of gengral health in the control group, the symptoms,life quality and sleep quality were superior to those before treatment in the two group (all P<0.01). The symptom and PSQI scores in the observation group were lower than those in the control group(P<0.01,P<0.05). The scores of general health, life vitality and mental health in the observation group were more apparently improved than those in the control group (all P<0.05). CONCLUSIONS: TENS at Neiguan(PC 6) and Zusanli(ST 36) can improve the clinical symptoms,life quality and sleep quality of GERD based on the conventional treatment. PMID: 29231475 [PubMed - indexed for MEDLINE]

[Effect and mechanism of electroacupuncture for postoperative ileus at perioperative stage].

Related Articles [Effect and mechanism of electroacupuncture for postoperative ileus at perioperative stage]. Zhongguo Zhen Jiu. 2017 Mar 12;37(3):291-296 Authors: Fang J, Wang W, Shao X, Du J, Fang J, Liu Z Abstract OBJECTIVE: To observe the intervention effect of electroacupuncture (EA) on small intestinal motility in the rats of postoperative ileus (POI) at perioperative stage and explore the mechanism on the regulation of interstitial cells of Cajal (ICC) in the treatment of POI. METHODS: Sixty heathy male SD rats were randomized into a sham-operation group, a model group, an EA group and a sham-EA group, 15 rats in each one. Except the sham-operation group, POI modeling was done in the rest groups. In the EA group, separately, 48 h, 24 h and 0.5 h before modeling, during modeling and 6 h, 12 h and 24 h after modeling, EA was given bilaterally to "Zusanli" (ST 36), 5 Hz, 1-2 mA, for 30 min. The sham-EA stimulation was given in the sham-EA group at the same time points. The same fixation was the only intervention in the model group. No intervention was applied in the sham-operation group. Five rats were selected randomly from each group 6 h, 12 h and 24 h after modeling for the determination of small intestine motility and they were sacrificed. Afterwards, the small intestinal muscular layer was collected for the determination of c-kit and P2X7 mRNA. In 24 h of modeling, the immunofluorescence test was done for c-kit determination. RESULTS: In 6 h, 12 h and 24 h of modeling, in the model group, the EA groupand the sham-EA group, the small intestine motility was apparently lower than that in the sham-operation group at the same time points (all P<0.01). In 6 h and 12 h of modeling, the small intestine motility in the EA group was not different significantly as compared with that in the model group (both P>0.05). In 24 h of modeling, the small intestine motility in the EA group was better than that in the model group and the sham-EA group at the same time points (both P<0.05). The difference was not significant between the sham-EA group and the model group (P>0.05). In 6 h, 12 h and 24 h of modeling, c-kit mRNA expression of small intestine muscular layer was reduced apparently in the model group (all P<0.01) and P2X7 mRNA expression did not change apparently (all P>0.05). In 24 h of modeling, as compared with the model group and the sham-EA group, c-kit mRNA expression and positive cell area in the small intestine muscular layer were increased in the EA group (all P<0.01). CONCLUSIONS: EA effectively increases the small intestinal motility in POI rats, shortens the recovery time, which is probably closely relevant with the increase of ICC count in small intestinal muscular layer. PMID: 29231437 [PubMed - indexed for MEDLINE]

[Protective effect of acupuncture preconditioning on oxidative stress injury induced by myocardial ischemia-reperfusion injury in rats].

Related Articles [Protective effect of acupuncture preconditioning on oxidative stress injury induced by myocardial ischemia-reperfusion injury in rats]. Zhongguo Zhen Jiu. 2017 Mar 12;37(3):285-290 Authors: Shao M, Li Y, Cui H, Jiang M, Tan Q Abstract OBJECTIVE: To observe the protective effect of acupuncture preconditioning at "Jiaji" (EX-B 2) on acute myocardial ischemia-reperfusion injury (MIRI) in the rats and explore the mechanism. METHODS: Fifty Wistar rats were randomly divided into a control group, a model group, a Jiaji group, a Neiguan group and a Quchi group, 10 rats in each one. In the Jiaji group, the Neiguan group and the Quchi group, electroacupuncture was given for preconditioning at "Jiaji" T4~T5 (EX-B 2), "Neiguan" (PC 6) and "Quchi" (LI 11) for 7 days before modeling. In the control group and the model group, the regular feeding was given, without any acupuncture. At the end of acupuncture, except the control group, ligating the left anterior descending coronary artery (LAD) was adopted to duplicate MIRI models in the rest groups. Electrocardio-gram (ECG) was monitored and ST-segment shift was analyzed. HE staining method was adopted to observe the morphology of cardiac tissue in the rats of the groups. The transmission electron microscope was used to observe myocardial cell ultrastructure. WST-1 method was used to determine the activity of serum superoxide dismutase (SOD), TBA method was used to determine the content of serum malondialehyde (MDA) and the real-time fluorescent quantitative PCR method to determine the expressions of Nrf 2 in ischemic myocardial tissue and downstream HO-1 gene. RESULTS: Compared with the control group, after LAD ligation, ST-segment was elevated and depressed in ECG apparently after reperfusion in the rest groups (all P<0.05). The ST-segment elevation in the Jiaji group and the Neiguan group was less than that in the model group (both P<0.05). Compared with the model group, SOD activity was increased apparently in the Jiaji group and the Neiguan group (both P<0.05), and MDA content was reduced apparently (both P<0.05). The effects in the Jiaji group were better than those in the Neiguan group (both P<0.05). Pathologically, "Jiajia" (EX-B 2) and "Neiguan" (PC 6) all improved the morphology of cardiac tissue and cell ultrastructure. The effects in the Jiaji group were much more significant and the improvements in the Quchi group were not apparent. Compared with the control group, the expressions of Nrf 2 and HO-1 gene in myocardial tissue were down-regulated in the model group (both P<0.05). Those were up-regulated apparently in the Jiaji group and the Neiguan group as compared with the model group (P<0.05, P<0.01). The up-regulation times of the expressions of Nrf 2 and HO-1 gene in the Jiajia group were the highest in comparison. CONCLUSIONS: Acupuncture preconditioning at "Jiaji" (EX-B 2) has the protective effect on cardiac ischemia and reperfusion damage, which is probably relevant with the up-regulation of Nrf 2-ARE pathway expression, the activation of endogenous anti-oxidative pathway, the improvement of oxygen free radical scavenging capacity and the alleviation of lipid peroxide damage. PMID: 29231436 [PubMed - indexed for MEDLINE]

[Transcutaneous vagus nerve stimulation for primary insomnia and affective disorder:a report of 35 cases].

Related Articles [Transcutaneous vagus nerve stimulation for primary insomnia and affective disorder:a report of 35 cases]. Zhongguo Zhen Jiu. 2017 Mar 12;37(3):269-273 Authors: Luo M, Qu X, Li S, Zhao J, Zhao Y, Jiao Y, Rong P Abstract OBJECTIVE: To observe and evaluate the clinical efficacy of transcutaneous vagus nerve stimulation (taVNS) at auricular concha for primary insomnia (PI) and affective disorder. METHODS: A total of 35 patients who met the diagnosis standard of PI in Diagnostic and statistical manual of mental disorders (5th edition) were included. The self-developed auricular vagus nerve stimulator (TENS-200A) was applied at auricular concha, 30 min per treatment, twice a day, 5 days a week for consecutive 4 weeks. The follow-up visit was conducted at the end of 6th week. The Pittsburg sleep quality index scale (PSQI), 17-items Hamilton depression scale (17HAMD) and Hamilton anxiety scale (HAMA) were applied for evaluation. The PSQI, HAMA and 17HAMD were observed before and after treatment; the safety was also observed. RESULTS: Compared before treatment, the PSQI was significantly decreased to (13.20±3.61) at the end of 2nd week (P<0.05); compared before treatment, the 17HAMD and HAMA were significantly decreased at the end of 4th week and 6th week (all P<0.05). No adverse reaction was observed. CONCLUSIONS: The taVNS could not only relieve PI symptoms, but also improve the depressive and anxiety symptoms, in addition, it may have positive long-term efficacy and safety. PMID: 29231433 [PubMed - indexed for MEDLINE]

[Transcutaneous electrical acupoint stimulation for pregnancy of in vitro fertilization-embryo transfer].

Related Articles [Transcutaneous electrical acupoint stimulation for pregnancy of in vitro fertilization-embryo transfer]. Zhongguo Zhen Jiu. 2017 Mar 12;37(3):253-255 Authors: Zhong J, Zhang L Abstract OBJECTIVE: To observe the impact of transcutaneous electrical acupoint stimulation (TEAS) before and after embryo transfer for the pregnancy of in vitro fertilization-embryo transfer (IVF-ET) patients. METHODS: A total of 1761 IVF-ET patients of natural cycle or hormone replacement cycle were randomly assigned into an observation group (735 cases) and a control group (1026 cases). IVF-ET was applied in the two groups. TEAS was used for 30 min separately in the observation group on 24 h before transfer and within 2 h after transfer. The acupoints were Zigong (EX-CA 1), Xuehai (SP 10) and Diji (SP 8); Zhongwan (CV 12), Guanyuan (CV 4), Zusanli (ST 36) and Taixi (KI 3). TEAS was not used in the control group. Biochemical pregnancy rate and clinical pregnancy rate were observed 14 d and 4-5 weeks after transfer in the two groups. RESULTS: The biochemical pregnancy rate in the observation group was 62.0% (456/735), which was better than 57.3% (588/1026) in the control group (P<0.05). The clinical pregnancy rate in the observation group was 51.2% (376/735), and it was better than 44.9% (461/1026) in the control group (P<0.05). CONCLUSIONS: TEAS could improve the pregnancy rate of IVF-ET patients, and it may be a safe and new assisted method for reproduction without pain. PMID: 29231430 [PubMed - indexed for MEDLINE]

[Comparison between manual acupuncture and electroacupuncture for hot flashes and sex hormone of perimenopausal syndrome].

Related Articles [Comparison between manual acupuncture and electroacupuncture for hot flashes and sex hormone of perimenopausal syndrome]. Zhongguo Zhen Jiu. 2017 Mar 12;37(3):247-252 Authors: Cao Z, Tang J, Xue Y, Wang Q, Li S, Zhou Y, Zhang W Abstract OBJECTIVE: To compare the effect and differences sex the influence of hormone levels of perimenopau-sal syndrome patients between manual acupuncture and electroacupuncture (EA). METHODS: A total of 50 cases with perimenopausal syndrome were randomly assigned into an manual acupuncture group (27 cases) and an EA group (23 cases), and 1 case dropped in the EA group. The acupoints in the two groups were Guanyuan (CV 4), Zigong (EX-CA 1), Tianshu (ST 25), and Sanyinjiao (SP 6). Acupuncture with 3-time small and even manipulation of lifting, thrusting and twirling was used in the acupuncture group, once 10 min. EA with sparse-dense wave and 10 Hz/50 Hz was applied in the EA group for 30 min. The treatments in the two groups were for continuous 8 weeks (24 times in total), once the other day, 3 times a week. The scores of 24-hour hot flashes even, menopausal rating scale (MRS) and menopause-specific quality of life questionnaire (MENQOL) were recorded before treatment and after 4-week and 8-week treatment, as well as 12 and 24 weeks after treatment. Serum sex hormone levels were tested before and after 8-week treatment as well as 12 weeks after treatment, including serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estracliol (E2). RESULTS: Compared with those before treatment, the 24-hour hot flashes even score, MRS and MENQOL scores were significantly lower after 4-week and 8-week treatments, 12 and 24 weeks after treatment (all P<0.05). All the above scores after 8-week treatment were lower than those after 4-week treatment (all P<0.05); and the scores 12 and 24 weeks after treatment were lower than those after 4-week and 8-week treatments (all P<0.05); all the scores after treatment were not significantly different at any time between the two groups (all P>0.05). Compared with those before treatment, serum FSH and E2 apparently improved in the two groups after 8-week treatment and 12 weeks after treatment (all P<0.05). LH levels did not significantly change in the two groups (all P>0.05). All the serum sex hormone levels showed no significant difference between the two groups (all P>0.05). CONCLUSIONS: Both acupuncture and EA can improve perimenopausal symptoms and serum sex hormone. The effects are similar. PMID: 29231429 [PubMed - indexed for MEDLINE]

[Electroacupuncture combined with catgut implantation for postoperative pain of mixed hemorrhoids].

Related Articles [Electroacupuncture combined with catgut implantation for postoperative pain of mixed hemorrhoids]. Zhongguo Zhen Jiu. 2017 Mar 12;37(3):243-246 Authors: Wen Y, Li J, Long Q, Lan X, Chen Y Abstract OBJECTIVE: To compare the clinical effect differences among electroacupuncture (EA) combined with catgut implantation, simple EA and simple catgut implantation for postoperative pain of mixed hemorrhoids. METHODS: A total of 120 patients were randomly assigned into a combination group, an EA group, and a catgut implantation group, 40 cases in each one. All the interventions were applied for 30 min before the operation. The acupoints were Changqiang (GV 1) and Chengshan (BL 57). The pain scores were compared among the three groups 4 h, 12 h, 3 d, and 7 d after operation, as well as the score of maximum pain score within 24 h (24 h Max) after operation, the pain duration score within 24 h after operation, and the total dose of aulin to relieve pain within 7 d after the operation. RESULTS: The scores in the combination group were better than those in the other two groups, including the pain scores at all the time points after operation, the 24 h Max score and the pain duration score within 24 h after the operation, as well as the dose of aulin within 7 d after the operation (all P<0.05). The pain scores 4 h and 12 h after operation and the 24 h Max socre in the EA group were better than those in the catgut implantation group (all P<0.05). The pain scores 3 d and 7 d after operation in the catgut implantation group were superior to those in the EA group (both P<0.05). The pain duration score within 24 h after operation in the EA group was better than that in the catgut implantation group (P<0.05). As for the aulin dose within 7 d after operation, the dosage in the catgut implantation group was less than that in the EA group (P<0.05). CONCLUSIONS: EA combined with catgut implantation is more effective than simple EA and simple catgut implantation for postoperative pain of mixed hemorrhoid. The analgesic effect of EA is stronger and works faster, but the duration of analgesia of catgut implantation is longer. The combination of the two Methods can achieve better analgesia. PMID: 29231428 [PubMed - indexed for MEDLINE]

Feasibility and safety of nerve stimulator attachment to energy-based devices: A porcine model study.

Related Articles Feasibility and safety of nerve stimulator attachment to energy-based devices: A porcine model study. Int J Surg. 2017 Dec;48:155-159 Authors: Shin SC, Sung ES, Choi SW, Kim SD, Jung DW, Kim SH, Ro JH, Lee JC, Lee BJ Abstract BACKGROUND: Recently, several energy-based devices (EBDs) have been developed and applied in the context of thyroid surgery. EBDs can reduce operation time, blood loss, and postoperative pain. Compared to conventional electrocautery, EBDs operate at a relatively lower temperature and produce minimal lateral tissue damage. Yet, during device operation, the tip of the EBD is hot enough to cause thermal nerve damage, increasing the need for surgeons to be cautious about EBD application. To increase the safety of EBDs, we attached nerve stimulators to the tips of two EBDs and compared them to conventional monopolar nerve stimulation using a porcine model. METHODS: Three piglets (30-40 kg) underwent total thyroidectomy after orotracheal intubation with a nerve integrity monitor (NIM) electromyography (EMG) endotracheal tube. Nerve stimulators were attached to two EBDs (Harmonic Focus®+ and LigaSure™). After dissection and identification of six recurrent laryngeal nerves in the three piglets, both of the EBDs with attached nerve stimulators and a conventional monopolar nerve stimulator were applied near the nerve and EMG parameters were recorded using the NIM 3.0 system. The stimulus intensity was varied from 5 mA to 1 mA and the maximum distance and amplitude at which nerve detection was achieved were measured. RESULTS: There were no statistically significant differences between the maximum distance or mean amplitude obtained from nerve stimulators attached to EBDs and those obtained from the conventional nerve stimulator. Additionally, there were no adverse EMG events related to the use of nerve stimulators attached to EBDs. CONCLUSIONS: Attachment of a nerve stimulator to an EBD for nerve detection during thyroidectomy was as safe and effective as attachment of a conventional nerve stimulator. Use of a nerve stimulator attachment may reduce the likelihood of EBD-associated nerve damage during thyroid surgery. PMID: 29100907 [PubMed - indexed for MEDLINE]

Outcome of vagus nerve stimulation for drug-resistant epilepsy: the first three years of a prospective Japanese registry.

Related Articles Outcome of vagus nerve stimulation for drug-resistant epilepsy: the first three years of a prospective Japanese registry. Epileptic Disord. 2017 Sep 01;19(3):327-338 Authors: Kawai K, Tanaka T, Baba H, Bunker M, Ikeda A, Inoue Y, Kameyama S, Kaneko S, Kato A, Nozawa T, Maruoka E, Osawa M, Otsuki T, Tsuji S, Watanabe E, Yamamoto T Abstract Vagus nerve stimulation (VNS) is an established option of adjunctive treatment for patients with drug-resistant epilepsy, however, evidence for long-term efficacy is still limited. Studies on clinical outcomes of VNS in Asia are also limited. We report the overall outcome of a national, prospective registry that included all patients implanted in Japan. The registry included patients of all ages with all seizure types who underwent VNS implantation for drug-resistant epilepsy in the first three years after approval of VNS in 2010. The registry excluded patients who were expected to benefit from resective surgery. Efficacy analysis was assessed based on the change in frequency of all seizure types and the rate of responders. Changes in cognitive, behavioural and social status, quality of life (QOL), antiepileptic drug (AED) use, and overall AED burden were analysed as other efficacy indices. A total of 385 patients were initially registered. Efficacy analyses included data from 362 patients. Age range at the time of VNS implantation was 12 months to 72 years; 21.5% of patients were under 12 years of age and 49.7% had prior epilepsy surgery. Follow-up rate was >90%, even at 36 months. Seizure control improved over time with median seizure reduction of 25.0%, 40.9%, 53.3%, 60.0%, and 66.2%, and responder rates of 38.9%, 46.8%, 55.8%, 57.7%, and 58.8% at three, six, 12, 24, and 36 months of VNS therapy, respectively. There were no substantial changes in other indices throughout the three years of the study, except for self/family-accessed QOL which improved over time. No new safety issues were identified. Although this was not a controlled comparative study, this prospective national registry of Japanese patients with drug-resistant epilepsy, with >90% follow-up rate, indicates long-term efficacy of VNS therapy which increased over time, over a period of up to three years. The limits of such trials, in terms of AED modifications and during follow-up and difficulties in seizure counting are also discussed. PMID: 28832004 [PubMed - indexed for MEDLINE]

Radiofrequency Thermocoagulation in Relieving Refractory Pain of Knee Osteoarthritis.

Related Articles Radiofrequency Thermocoagulation in Relieving Refractory Pain of Knee Osteoarthritis. Am J Ther. 2017 Nov/Dec;24(6):e693-e700 Authors: Shen WS, Xu XQ, Zhai NN, Zhou ZS, Shao J, Yu YH Abstract To investigate the efficacy of radiofrequency thermocoagulation (RFTC) in relieving refractory pain of knee osteoarthritis (OA), we selected 54 patients with chronic knee OA pain, 27 treated with RFTC (case group) and 27 receiving regular treatments (control group). Response evaluations were conducted before treatment, and at the termination of treatment, and 3-month follow-up, applying the visual analog scale, the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), and American Knee Society Score (AKSS). Data analyses were performed with SPSS 21.0. At the termination of treatments and 3-month follow-ups, cases gained significantly increased scores in vitality, bodily pain, general health perceptions, physical functioning, and social role functioning by SF-36 scaling and in pain, range of motion, stability, walking, and stair climbing by AKSS (all P < 0.05). Controls received higher scores by AKSS in pain at the termination of treatments and in pain, range of motion, and walking at the termination of 3-month follow-ups (all P < 0.05). Both cases and controls presented significant difference between visual analog scale scores before treatments and those at the termination of 3-month follow-ups (both P < 0.05). All patients felt less pain after treatments, cases presenting better improvement (P < 0.05). Pain was stronger in females compared with males and in a positive correlation with age while had no obvious relation to disease course. In conclusion, RFTC may have better efficacy in relieving refractory pain and promoting function recovery in patients with knee OA than regular treatment. PMID: 26938761 [PubMed - indexed for MEDLINE]