Cybermedlife - Therapeutic Actions Loving

Raised plasma nerve growth factor levels associated with early-stage romantic love.

Abstract Title: Raised plasma nerve growth factor levels associated with early-stage romantic love. Abstract Source: Psychoneuroendocrinology. 2006 Apr;31(3):288-94. Epub 2005 Nov 10. PMID: 16289361 Abstract Author(s): Enzo Emanuele, Pierluigi Politi, Marika Bianchi, Piercarlo Minoretti, Marco Bertona, Diego Geroldi Article Affiliation: Interdepartmental Center for Research in Molecular Medicine, CIRMC, University of Pavia, Viale Taramelli 24, I-27100 Pavia, Italy. This email address is being protected from spambots. You need JavaScript enabled to view it. Abstract: Our current knowledge of the neurobiology of romantic love remains scanty. In view of the complexity of a sentiment like love, it would not be surprising that a diversity of biochemical mechanisms could be involved in the mood changes of the initial stage of a romance. In the present study, we have examined whether the early romantic phase of a loving relationship could be associated with alterations in circulating levels of neurotrophins (NTs). Plasma levels of NGF, BDNF, NT-3 and NT-4 were measured in a total of 58 subjects who had recently fallen in love and compared with those of two control groups, consisting of subjects who were either single or were already engaged in a long-lasting relationship. NGF level was significantly higher (p<0.001) in the subjects in love [mean (SEM): 227 (14) pg/ml] than in either the subjects with a long-lasting relationship [123 (10) pg/ml] or the subjects with no relationship [149 (12) pg/ml]. Notably, there was also a significant positive correlation between levels of NGF and the intensity of romantic love as assessed with the passionate love scale (r = 0.34; p = 0.007). No differences in the concentrations of other NTs were detected. In 39 subjects in love who-after 12-24 months-maintained the same relationship but were no longer in the same mental state to which they had referred during the initial evaluation, plasma NGF levels decreased and became indistinguishable from those of the control groups. Taken together, these findings suggest that some behavioural and/or psychological features associated with falling in love could be related to raised NGF levels in the bloodstream. Article Published Date : Apr 01, 2006
Therapeutic Actions Loving

NCBI pubmed

Golimumab in the treatment of psoriatic arthritis.

Related Articles Golimumab in the treatment of psoriatic arthritis. Expert Rev Clin Immunol. 2018 Sep 17;: Authors: Love TJ, Kavanaugh A Abstract INTRODUCTION: Psoriatic arthritis is an inflammatory arthritis that can be aggressive and destructive, resulting in significant morbidity. While many new agents have been approved for the treatment of psoriatic arthritis over the past decade, TNF inhibitors remain an anchor treatment, in part based on extensive clinical experience. Recently, the TNF inhibitor golimumab was approved for intravenous use in psoriatic arthritis. Areas covered: This expert review presents an overview of the currently available treatment options for psoriatic arthritis with a focus on the evidence from clinical trials supporting the use of golimumab in psoriatic arthritis. This information is placed in context with recent advances in the understanding of psoriatic arthritis pathogenesis and treatment. Expert commentary: The rapid growth of treatment options available for psoriatic arthritis has brought the prospect of personalized treatment selection closer to reality but improved understanding of the domains of psoriatic arthritis and new biomarkers may be needed before such changes reach the clinic. Until patients who are most likely to benefit from a given agent can be identified and then treated accordingly, TNF inhibitors will likely remain a central option and their further development, such as the introduction of an intravenous form of golimumab, remains an important part of treatment improvement. PMID: 30221556 [PubMed - as supplied by publisher]

"I Feel It In My Heart When My Parents Fight": Experiences of 7-9-Year-Old Children of Alcoholics.

Related Articles "I Feel It In My Heart When My Parents Fight": Experiences of 7-9-Year-Old Children of Alcoholics. Child Adolesc Social Work J. 2018;35(5):531-540 Authors: Tinnfält A, Fröding K, Larsson M, Dalal K Abstract Children are vulnerable when exposed to parental alcohol abuse. Although much is known about children of alcoholics (COA), research examining the experiences of younger COA is scarce. To gain knowledge of the consequences for these children, it is important to ask the children themselves. This study explored the consequences for a child of having an alcoholic parent, from the point of view of 7-9-year-old COA. Eighteen children were interviewed, whose alcoholic parent was undergoing treatment, using a vignette. In the analysis, using qualitative content analysis, the findings show that the children of this young age had much experiences and took a great responsibility for their alcoholic parent, and the family. The most significant feeling of the children was a feeling of sadness. They tried to control the situation in different ways. They wished for a change in the future, but despite problems in the family they described things they did together with a loving parent. Implications include the importance of listening to and supporting all COA, also children as young as 7-9 years old. Further studies should address the support that can and should be offered to COA. PMID: 30220781 [PubMed]

Women Who Love: An Explorative Study on Experiences of Lesbian and Bisexual Women with a Mild Intellectual Disability in The Netherlands.

Related Articles Women Who Love: An Explorative Study on Experiences of Lesbian and Bisexual Women with a Mild Intellectual Disability in The Netherlands. Sex Disabil. 2018;36(3):249-264 Authors: Stoffelen JMT, Schaafsma D, Kok G, Curfs LMG Abstract Empirical research that addresses sexual orientation in people with an intellectual disability (ID) is limited, and very little is known regarding the personal experiences of lesbian and bisexual women with ID. This study set out to answer the question: What are the experiences of lesbian and bisexual women with a mild intellectual disability in the Netherlands? Ten lesbian and bisexual women (average age of 33 years) with a mild intellectual disability took part in our study comprising of semi-structured interviews. Participants reported that they had found it hard to talk to others about sensitive subjects such as their sexuality, and had been left to figure out information regarding their sexual orientation without support or guidance. Our results point to a lack of information, sexual education and role models when it comes to lesbian sex and women with an intellectual disability. Social contact was often limited, and participants experienced difficulties finding a partner. Furthermore, participants often had to cope with mental health problems and had struggled with loneliness, depression and addiction. Last but not least, our participants reported that they had been discriminated against. Coming out (revealing your sexual orientation) is not easy when you have an intellectual disability. To enable women with ID who have lesbian or bisexual feelings to understand and secure their sexual rights in their daily lives is important. Therefore, it is necessary to provide support in the following domains: sexual education and training, social contact and assertiveness. PMID: 30220750 [PubMed]

Low prevalence of hepatitis E in Iceland: a seroepidemiological study.

Related Articles Low prevalence of hepatitis E in Iceland: a seroepidemiological study. Scand J Gastroenterol. 2018 Mar;53(3):293-296 Authors: Löve A, Björnsdottir TB, Olafsson S, Björnsson ES Abstract OBJECTIVE: Hepatitis E virus (HEV) infection has been reported to be more prevalent in the developed countries than previously thought. HEV infection is an important differential diagnosis in patients with drug-induced liver injury (DILI). The prevalence of hepatitis E was investigated in the general population of Iceland, among pig farmers and patients with DILI. MATERIALS AND METHODS: Serum samples were tested for hepatitis E IgG, with two commercial ELISA tests: Diagnostic Bioprobes Srl. (Dia Pro) and the Wantai HEV IgG and subjects repeatedly reactive were tested with an immunoblot assay (RecomLINE). Three groups were tested: (1) healthy volunteers (HV), (2) pig farm workers (PFWs) and (3) patients participating in a nationwide prospective study on DILI. RESULTS: Overall 291 individuals were tested, HV (n = 195), PFW (n = 21) and DILI (n = 75). Only 6/291 (2.1%) tested positive for IgG antibodies to HEV in all three tests. Three HV were HEV IgG antibody positive and three in the DILI group. One PFW tested positive in the Dia Pro and Wantai tests but not in the immunoblot assay. All but one of the positive individuals in all three tests was either of foreign national origin or had spent extended period of time outside of Iceland. CONCLUSIONS: The seroprevalence of hepatitis E appears to be lower in Iceland than majority of recent studies in other western countries have demonstrated. This may be due to relative isolation and severe restriction on import of livestock from other countries. PMID: 29310474 [PubMed - indexed for MEDLINE]

Single-cell analysis at the threshold.

Related Articles Single-cell analysis at the threshold. Nat Biotechnol. 2016 11 08;34(11):1111-1118 Authors: Chen X, Love JC, Navin NE, Pachter L, Stubbington MJ, Svensson V, Sweedler JV, Teichmann SA PMID: 27824834 [PubMed - indexed for MEDLINE]