A new nonpharmacological method in fibromyalgia: the use of wool.
J Altern Complement Med. 2009 Apr;15(4):399-405. PMID: 19388862
Emine Kara Kiyak
OBJECTIVES: The aim was to assess the effect of wool use in patients with fibromyalgia. BACKGROUND: Various studies concerning the treatment of patients with fibromyalgia using nonpharmacological methods have been carried out. There are, however, no reports on the use of wool clothing and bedding in treating these patients. DESIGN AND METHODS: The study employed two-group, experimental design. A total of 50 patients with fibromyalgia, based on the criteria of the American College of Rheumatology, were selected for the study. They were distributed equally into two groups: a control group and a treatment group. The 25 patients in each group were randomly selected and the compositions of the two groups were statistically identical. The patients in the treatment group wore woolen underwear (which covered the body from the shoulders to the thighs) and used woolen bedding such as woolen bed liner, woolen quilt and pillow during the experimental period of 6 weeks. All patients were assessed at the beginning the trial (pre-test) and the end of 6th (post-test) week. Data were collected using the visual analogue scale (0-10), tender points count, and Fibromyalgia Impact Questionnaire. RESULTS: Patients in the treatment group reported significant improvements in their conditions including a reduction in pain levels, tender point counts, and all scores of the Fibromyalgia Impact Questionnaire (p <or= 0.001). CONCLUSIONS: The use of woolen underwear and woolen bedding were effective in reducing the symptoms of patients suffering from fibromyalgia. The use of wool is recommended as a means of treatment for alleviating the pain of fibromyalgia. RELEVANCE TO CLINICAL PRACTICE: Nurses provide professional support to patients with fibromyalgia. They select suitable clothes and sleeping materials for their patients with this object in mind: to keep their patients warm and to protect them from the cold.
Article Published Date : Apr 01, 2009
Managing anxiety in eating disorders with knitting.
Eat Weight Disord. 2009 Mar;14(1):e1-5. PMID: 19367130
M Clave-Brule, A Mazloum, R J Park, E J Harbottle, C L Birmingham
OBJECTIVE: Recovery from anorexia nervosa (AN) is often confounded by intrusive, anxious preoccupations with control of eating, weight and shape. These are distressing and represent a potential barrier to psychological change. Theoretical and empirical evidence suggests that performing a concurrent visuospatial task reduces the emotional intensity of distressing images. We assessed whether the visuospatial task of knitting influences the anxious preoccupation experienced by inpatients with AN. METHOD: Prospective interventional cohort. SUBJECTS: Thirty-eight women with AN admitted to a specialized eating disorder unit. INTERVENTION: All subjects were given knitting lessons and free access to supplies. MEASURE: Subjects were asked to report the qualitative effects of knitting on their psychological state using a self-report questionnaire. RESULTS: Patients reported a subjective reduction in anxious preoccupation when knitting. In particular, 28/38 (74%) reported it lessened the intensity of their fears and thoughts and cleared their minds of eating disorder preoccupations, 28/38 (74%) reported it had a calming and therapeutic effect and 20/38 (53%) reported it provided satisfaction, pride and a sense of accomplishment. DISCUSSION: This preliminary data suggests that knitting may benefit inpatients with eating disorders by reducing their anxious preoccupations about eating, weight and shape control. The specificity of this effect is yet to be determined. This preliminary outcome requires further controlled study in AN subjects. From a clinical perspective, knitting is inexpensive, easily learned, can continue during social interaction, and can provide a sense of accomplishment. The theoretical and empirical rationale for this observation, and implications for deriving alternative strategies to augment treatment in AN, are discussed.
Article Published Date : Mar 01, 2009
Determination of human γδ T cell-mediated cytotoxicity using a non-radioactive assay system.
J Immunol Methods. 2019 Jan 14;:
Authors: Tagod MSO, Mizuta S, Sakai Y, Iwasaki M, Shiraishi K, Senju H, Mukae H, Morita CT, Tanaka Y
The adoptive transfer of immune effector cells, such as CD8+ killer αβ T cells, γδ T cells, NK (natural killer) cells, and genetically-modified T cells, has been receiving increasing attention. It is essential to determine cellular cytotoxicity so as to monitor the function and quality of ex vivo-expanded immune effector cells before infusion. The most common method is the [51Cr]-sodium chromate release assay. It is, however, preferable to avoid the use of radioactive materials in clinical laboratories. In order to establish a non-radioactive alternative to the standard radioactive assay, we previously synthesized a chelate-forming prodrug (BM-HT) and demonstrated that a combination of BM-HT and europium (Eu3+) was useful to determine NK cell-mediated cytotoxicity. In the present study, we examined whether or not this improved assay system could be used to determine the cellular cytotoxicity exhibited by Vγ2Vδ2+ γδ T cells. In addition, we compared Eu3+ and terbium (Tb3+) in the measurement of cellular cytotoxicity. Our assay system using BM-HT could be used successfully for the analysis of both γδ T cell receptor (TCR)- and CD16-mediated cytotoxicity. When the intensity of fluorescence was compared between Eu3+ and Tb3+, Tb3+ chelate was more sensitive than Eu3+ chelate, suggesting that the detection system using Tb3+ is superior to Eu3+ when tumor cells are not efficiently labeled with BM-HT. The method established herein is expected to promote the development of novel adoptive cell therapies for cancer.
PMID: 30654042 [PubMed - as supplied by publisher]
Phyto-polyphenols as potential inhibitors of breast cancer metastasis.
Mol Med. 2018 06 05;24(1):29
Authors: Avtanski D, Poretsky L
Breast cancer is the most common cancer among women as metastasis is currently the main cause of mortality. Breast cancer cells undergoing metastasis acquire resistance to death signals and increase of cellular motility and invasiveness.Plants are rich in polyphenolic compounds, many of them with known medicinal effects. Various phyto-polyphenols have also been demonstrated to suppress cancer growth. Their mechanism of action is usually pleiotropic as they target multiple signaling pathways regulating key cellular processes such as proliferation, apoptosis and differentiation. Importantly, some phyto- polyphenols show low level of toxicity to untransformed cells, but selective suppressing effects on cancer cells proliferation and differentiation.In this review, we summarize the current information about the mechanism of action of some phyto-polyphenols that have demonstrated anti-carcinogenic activities in vitro and in vivo. Gained knowledge of how these natural polyphenolic compounds work can give us a clue for the development of novel anti-metastatic agents.
PMID: 30134816 [PubMed - indexed for MEDLINE]
The Impact of Music on the Self in Dementia.
J Alzheimers Dis. 2018;61(3):827-841
Authors: Baird A, Thompson WF
In this review, we consider how the onset and progression of dementia can disrupt one's sense of self, and propose that music is an ideal tool for alleviating this distressing symptom. Various aspects of the self can be impaired in people with dementia, depending on how the self is defined. There are anecdotal reports that music can 'bring people back to themselves' in the face of dementia, but there have been scarce empirical investigations of this topic. Motivated by a consideration of the existing literature, we outline a novel theoretical framework that accounts for the relationship between music and the self in people with dementia. We propose that music has a number of 'design features' that make it uniquely equipped to engage multiple aspects of the self. We suggest that each design feature interacts with different aspects of the self to varying degrees, promoting overall wellbeing. We discuss how existing research on music and dementia fits within this framework, and describe two case studies in which music was an ideal stimulus for reaffirming their sense of self. Our framework may be useful for the diagnosis and treatment of impairments of self in people with dementia, and highlights how music, given its ability to engage all aspects of the self simultaneously, can result in an overall enhanced sense of self.
PMID: 29332051 [PubMed - indexed for MEDLINE]
Auditory speed tasks as potential candidates for the study of cognitive ageing.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2018 03;25(2):167-185
Authors: Zajac IT, Nettelbeck T
Speed of information processing is an important cognitive ability. It facilitates the efficient operation of higher order cognitive functions, such as reasoning, and is implicated in various models of cognitive decline. The present study considers the potential benefits of expanding the measurement of processing speed to include the auditory modality. It examines the reliability and factorial structure of a variety of auditory and visual speed tasks in a sample of N = 138 older adults aged between 51 and 82 years. Our findings demonstrate that auditory measures can be used to assess processing speed as indexed by existing widely used tests of this ability. Moreover, the inclusion of auditory tasks significantly increases the relationship between processing speed and general cognitive ability. This novel research provides strong evidence of the suitability of auditory speed tasks for the study of cognitive function in older people, and demonstrates the importance of expanding cognitive measurement to include alternate modalities.
PMID: 28019125 [PubMed - indexed for MEDLINE]