Effectiveness of a noninvasive digital infrared thermal imaging system in the detection of breast cancer.
Am J Surg. 2008 Oct;196(4):523-6. PMID: 18809055
Nimmi Arora, Diana Martins, Danielle Ruggerio, Eleni Tousimis, Alexander J Swistel, Michael P Osborne, Rache M Simmons
Department of Surgery, New York Presbyterian Hospital-Cornell, New York, NY, USA.
BACKGROUND: Digital infrared thermal imaging (DITI) has resurfaced in this era of modernized computer technology. Its role in the detection of breast cancer is evaluated.
METHODS: In this prospective clinical trial, 92 patients for whom a breast biopsy was recommended based on prior mammogram or ultrasound underwent DITI. Three scores were generated: an overall risk score in the screening mode, a clinical score based on patient information, and a third assessment by artificial neural network.
RESULTS: Sixty of 94 biopsies were malignant and 34 were benign. DITI identified 58 of 60 malignancies, with 97% sensitivity, 44% specificity, and 82% negative predictive value depending on the mode used. Compared to an overall risk score of 0, a score of 3 or greater was significantly more likely to be associated with malignancy (30% vs 90%, P<.03).
CONCLUSION: DITI is a valuable adjunct to mammography and ultrasound, especially in women with dense breast parenchyma.
Article Published Date : Oct 01, 2008
Efficacy of computerized infrared imaging analysis to evaluate mammographically suspicious lesions.
AJR Am J Roentgenol. 2003 Jan;180(1):263-9. PMID: 12490517
Y R Parisky, A Sardi, R Hamm, K Hughes, L Esserman, S Rust, K Callahan
USC/Norris Cancer Center, 1441 Eastlake Ave., Los Angeles, CA 90033, USA.
OBJECTIVE: The purpose of this clinical trial was to determine the efficacy of a dynamic computerized infrared imaging system for distinguishing between benign and malignant lesions in patients undergoing biopsy on the basis of mammographic findings.
SUBJECTS AND METHODS: A 4-year clinical trial was conducted at five institutions using infrared imaging of patients for whom breast biopsy had been recommended. The data from a blinded subject set were obtained in 769 subjects with 875 biopsied lesions resulting in 187 malignant and 688 benign findings. The infrared technique records a series of sequential images that provides an assessment of the infrared information in a mammographically identified area. The suspicious area is localized on the infrared image by the radiologist using mammograms, and an index of suspicion is determined, yielding a negative or positive result.
RESULTS: In the 875 biopsied lesions, the index of suspicion resulted in a 97% sensitivity, a 14% specificity, a 95% negative predictive value, and a 24% positive predictive value. Lesions that were assessed as false-negative by infrared analysis were microcalcifications, so an additional analysis was performed in a subset excluding lesions described only as microcalcification. In this restricted subset of 448 subjects with 479 lesions and 110 malignancies, the index of suspicion resulted in a 99% sensitivity, an 18% specificity, a 99% negative predictive value, and a 27% positive predictive value. Analysis of infrared imaging performance in all 875 biopsied lesions revealed that specificity was statistically improved in dense breast tissue compared with fatty breast tissue.
CONCLUSION: Infrared imaging offers a safe noninvasive procedure that would be valuable as an adjunct to mammography in determining whether a lesion is benign or malignant.
Article Published Date : Jan 01, 2003
Study Type : Human Study
Retrospective Outcome Evaluation of Cervical Nucleoplasty Using Digital Infrared Thermographic Imaging.
Neurospine. 2018 Oct 07;:
Authors: Kim DH, Kim YS, Shin SJ, Kang H, Kim S, Shin HY
Purpose: Percutaneous cervical nucleoplasty (PCN) is used to treat cervical disc herniation. Radiological imaging studies, including, plain radiography, computed tomography (CT), and magnetic resonance imaging (MRI), have been used to make early predictions of cervical spinal surgery outcomes. However, simple radiological studies do not provide sufficiently detailed information; moreover, CT and MRI are highly expensive. Here we aimed to elucidate the usefulness of digital infrared thermography imaging (DITI) as an outcome marker after cervical nucleoplasty by correlating the changes in thermal differences (ΔTD) with the changes in pain intensity after PCN expressed as visual analogue scale (ΔVAS) scores.
Materials and Methods: For this study, 255 patients treated with PCN in *** Spine Hospital between March 2012 and August 2014 were included. In each patient, demographic data, including preoperative MRI results, ΔVAS, and ΔTD at the corresponding disc level treated with PCN, subjective symptom improvement, procedure-related discomfort, overall satisfaction, and adverse effects, were collected and evaluated up to 3 months retrospectively.
Results: TD and VAS scores were improved after PCN (P < 0.05), but ΔTD had no significant correlation with ΔVAS. If the preoperative TD was larger, the postoperative VAS was worse and the pain relief (ΔVAS) after PCN was smaller (P < 0.05). Only few adverse effects were noticeable after PCN.
Conclusion: DITI, which was used to evaluate the outcomes after cervical nucleoplasty showed that the ΔTD does not seem to reflect the ΔVAS after PCN. However, preoperative DITI findings could be useful for predicting the VAS reduction and clinical improvement after PCN.
PMID: 30653911 [PubMed - as supplied by publisher]
Safety and effectiveness of stereotactic laser ablation for epileptogenic cerebral cavernous malformations.
Epilepsia. 2019 Jan 17;:
Authors: Willie JT, Malcolm JG, Stern MA, Lowder LO, Neill SG, Cabaniss BT, Drane DL, Gross RE
OBJECTIVE: Magnetic resonance (MR) thermography-guided laser interstitial thermal therapy, or stereotactic laser ablation (SLA), is a minimally invasive alternative to open surgery for focal epilepsy caused by cerebral cavernous malformations (CCMs). We examined the safety and effectiveness of SLA of epileptogenic CCMs.
METHODS: We retrospectively analyzed 19 consecutive patients who presented with focal seizures associated with a CCM. Each patient underwent SLA of the CCM and adjacent cortex followed by standard clinical and imaging follow-up.
RESULTS: All but one patient had chronic medically refractory epilepsy (median duration 8 years, range 0.5-52 years). Lesions were located in the temporal (13), frontal (five), and parietal (one) lobes. CCMs induced magnetic susceptibility artifacts during thermometry, but perilesional cortex was easily visualized. Fourteen of 17 patients (82%) with >12 months of follow-up achieved Engel class I outcomes, of which 10 (59%) were Engel class IA. Two patients who were not seizure-free from SLA alone became so following intracranial electrode-guided open resection. Delayed postsurgical imaging validated CCM involution (median 83% volume reduction) and ablation of surrounding cortex. Histopathologic examination of one previously ablated CCM following open surgery confirmed obliteration. SLA caused no detectable hemorrhages. Two symptomatic neurologic deficits (visual and motor) were predictable, and neither was permanently disabling.
SIGNIFICANCE: In a consecutive retrospective series, MR thermography-guided SLA was an effective alternative to open surgery for epileptogenic CCM. The approach was free of hemorrhagic complications, and clinically significant neurologic deficits were predictable. SLA presents no barrier to subsequent open surgery when needed.
PMID: 30653657 [PubMed - as supplied by publisher]