CYBERMED LIFE - ORGANIC  & NATURAL LIVING

Cybermedlife - Therapeutic Actions Watchful Waiting

Risk factors for persistent cervical intraepithelial neoplasia grades 1 and 2: managed by watchful waiting. 📎

Abstract Title: Risk factors for persistent cervical intraepithelial neoplasia grades 1 and 2: managed by watchful waiting. Abstract Source: J Low Genit Tract Dis. 2011 Oct ;15(4):268-75. PMID: 21811178 Abstract Author(s): Gloria Y F Ho, Mark H Einstein, Seymour L Romney, Anna S Kadish, Maria Abadi, Magdy Mikhail, Jayasri Basu, Benjamin Thysen, Laura Reimers, Prabhudas R Palan, Shelly Trim, Nafisseh Soroudi, Robert D Burk, Article Affiliation: Departments of Epidemiology&Population Health, Albert Einstein College of Medicine, NY, USA. This email address is being protected from spambots. You need JavaScript enabled to view it. Abstract: OBJECTIVE: : This study examines risk factors for persistent cervical intraepithelial neoplasia (CIN) and examines whether human papillomavirus (HPV) testing predicts persistent lesions. MATERIALS AND METHODS: : Women with histologically diagnosed CIN 1 or CIN 2 (n = 206) were followed up every 3 months without treatment. Human papillomavirus genotyping, plasma levels of ascorbic acid, and red blood cell folate levels were obtained. Cervical biopsy at 12 months determined the presence of CIN. Relative risk (RR) was estimated by log-linked binomial regression models. RESULTS: : At 12 months, 70% of CIN 1 versus 54% of CIN 2 lesions spontaneously regressed (p<.001). Levels of folate or ascorbic acid were not associated with persistent CIN at 12 months. Compared with HPV-negative women, those with multiple HPV types (RRs ranged from 1.68 to 2.17 at each follow-up visit) or high-risk types (RRs range = 1.74-2.09) were at increased risk for persistent CIN; women with HPV-16/18 had the highest risk (RRs range = 1.91-2.21). Persistent infection with a high-risk type was also associated with persistent CIN (RRs range = 1.50-2.35). Typing for high-risk HPVs at 6 months only had a sensitivity of 46% in predicting persistence of any lesions at 12 months. CONCLUSIONS: : Spontaneous regression of CIN 1 and 2 occurs frequently within 12 months. Human papillomavirus infection is the major risk factor for persistent CIN. However, HPV testing cannot reliably predict persistence of any lesion. Article Published Date : Sep 30, 2011

Spontaneous partial regression of hepatocellular carcinoma in a cirrhotic patient.

Abstract Title: Spontaneous partial regression of hepatocellular carcinoma in a cirrhotic patient. Abstract Source: Ann Hepatol. 2007 Jan-Mar;6(1):66-9. PMID: 17297433 Abstract Author(s): Judith Meza-Junco, Aldo J Montaño-Loza, Braulio Martinez-Benítez, Tatiana Cabrera-Aleksandrova Article Affiliation: Department of Oncology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City. This email address is being protected from spambots. You need JavaScript enabled to view it. Abstract: Spontaneous regression of a malignant tumor is an exceptional phenomenon. A 56-year-old woman with liver cirrhosis related to chronic hepatitis C presented with a liver tumor. Partial regression of a hepatocellular carcinoma was diagnosed by imaging studies that showed progressive diminution of the size of the tumor and changes in the tumor markers. However, because of the persistence of the tumor and uncertainty in the diagnosis we recommended surgery. A hepatectomy was performed and a hepatocellular carcinoma moderately differentiated was found. The patient is now doing well and without any evidence of recurrence at 25 months after surgery. We found 61 case reports that have been published from 1982 to September 2006, with apparently spontaneous regression of hepatocellular carcinoma. The precise mechanism regarding the spontaneous regression of this tumor is not fully understood, either ischemia due to rapid growth of the neoplasia or particular inflammatory and immunologic mechanisms may be involved in the regression of the hepatocellular carcinoma. Article Published Date : Jan 01, 2007

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