 Vitamin D and non-Hodgkin lymphoma risk in adults - a review..pdf | [Vitamin D and non-Hodgkin lymphoma risk in adults: a review.] | 91 kB |
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Vitamin D and non-Hodgkin lymphoma risk in adults: a review.
Department of Community and Preventive Medicine, University of Rochester, Rochester, NY 14642, USA. This email address is being protected from spambots. You need JavaScript enabled to view it.
Animal and human studies support a protective effect of vitamin D sufficiency related to malignancy by uncovering paracrine and autocrine effects of extra-renal 25-hydroxyvitamin D (25(OH)D) activation including regulation of cell cycle proliferation, apoptosis induction, and increased cell differentiation signaling. Recent epidemiologic studies demonstrate a reduction in non-Hodgkin lymphoma (NHL) risk with increased sunlight exposure. As sunlight is a major vitamin D source, it has been suggested that vitamin D status may mediate this observed association. This review provides a comprehensive discussion of the current epidemiologic evidence with regard to the investigation of an association between vitamin D status and NHL risk.
