Postmenopausal breast cancer
risk and dietary patterns in the E3N-EPIC prospective cohort study.
Am J Epidemiol. 2009 Nov 15;170(10):1257-67. Epub 2009 Oct 14. PMID: 19828509
Vanessa Cottet, Mathilde Touvier, Agnès Fournier, Marina S Touillaud, Lionel Lafay, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault
Since evidence relating diet to breast cancer
risk is not sufficiently consistent to elaborate preventive proposals, the authors examined the association between dietary patterns and breast cancer
risk in a large French cohort study. The analyses included 2,381 postmenopausal invasive breast cancer
cases diagnosed during a median 9.7-year follow-up period (1993-2005) among 65,374 women from the E3N-EPIC cohort. Scores for dietary patterns were obtained by factor analysis, and breast cancer
hazard ratios were estimated by Cox proportional hazards regression for the highest quartile of dietary pattern score versus the lowest. Two dietary patterns were identified: "alcohol/Western" (essentially meat products, French fries, appetizers, rice/pasta, potatoes, pulses, pizza/pies, canned fish, eggs, alcoholic beverages, cakes, mayonnaise, and butter/cream) and "healthy/Mediterranean" (essentially vegetables, fruits, seafood, olive oil, and sunflower oil). The first pattern was positively associated with breast cancer
risk (hazard ratio = 1.20, 95% confidence interval (CI): 1.03, 1.38; P = 0.007 for linear trend), especially when tumors were estrogen receptor-positive/progesterone receptor-positive. The "healthy/Mediterranean" pattern was negatively associated with breast cancer risk (hazard ratio = 0.85, 95% CI: 0.75, 0.95; P = 0.003 for linear trend), especially when tumors were estrogen receptor-positive/progesterone receptor-negative. Adherence to a diet comprising mostly fruits, vegetables, fish, and olive/sunflower oil, along with avoidance of Western-type foods, may contribute to a substantial reduction in postmenopausal breast cancer risk.
Article Published Date : Nov 15, 2009