Cybermedlife - Therapeutic Actions Measles Infection

Allergic disease and atopic sensitization in children in relation to measles vaccination and measles infection.

Abstract Title: Allergic disease and atopic sensitization in children in relation to measles vaccination and measles infection. Abstract Source: Pediatrics. 2009 Mar;123(3):771-8. PMID: 19255001 Abstract Author(s): Helen Rosenlund, Anna Bergström, Johan S Alm, Jackie Swartz, Annika Scheynius, Marianne van Hage, Kari Johansen, Bert Brunekreef, Erika von Mutius, Markus J Ege, Josef Riedler, Charlotte Braun-Fahrländer, Marco Waser, Göran Pershagen, Article Affiliation: Karolinska Institutet, Institute of Environmental Medicine, Department of Environmental Epidemiology, Box 210, SE-171 77 Stockholm, Sweden. This email address is being protected from spambots. You need JavaScript enabled to view it. Abstract: OBJECTIVE: Our aim was to investigate the role of measles vaccination and measles infection in the development of allergic disease and atopic sensitization. METHODS: A total of 14 893 children were included from the cross-sectional, multicenter Prevention of Allergy-Risk Factors for Sensitization in Children Related to Farming and Anthroposophic Lifestyle study, conducted in 5 European countries (Austria, Germany, the Netherlands, Sweden, and Switzerland). The children were between 5 and 13 years of age and represented farm children, Steiner-school children, and 2 reference groups. Children attending Steiner schools often have an anthroposophic (holistic) lifestyle in which some immunizations are avoided or postponed. Parental questionnaires provided information on exposure and lifestyle factors as well as symptoms and diagnoses in the children. A sample of the children was invited for additional tests, and 4049 children provided a blood sample for immunoglobulin E analyses. Only children with complete information on measles vaccination and infection were included in the analyses (84%). RESULTS: In the whole group of children, atopic sensitization was inversely associated with measles infection, and a similar tendency was seen for measles vaccination. To reduce risks of disease-related modification of exposure, children who reported symptoms of wheezing and/or eczema debuting during first year of life were excluded from some analyses. After this exclusion, inverse associations were observed between measles infection and "any allergic symptom" and "any diagnosis of allergy by a physician." However, no associations were found between measles vaccination and allergic disease. CONCLUSION: Our data suggest that measles infection may protect against allergic disease in children. Article Published Date : Mar 01, 2009
Therapeutic Actions Measles Infection

NCBI pubmed

The Epidemiology of Otosclerosis in a British Cohort.

The Epidemiology of Otosclerosis in a British Cohort. Otol Neurotol. 2019 Jan;40(1):22-30 Authors: Crompton M, Cadge BA, Ziff JL, Mowat AJ, Nash R, Lavy JA, Powell HRF, Aldren CP, Saeed SR, Dawson SJ Abstract OBJECTIVE: To analyse the epidemiology of otosclerosis in a British cohort collected between 2011 and 2017. DESIGN: Retrospective cohort study. SETTING: Five UK ENT Departments. PATIENTS: Patients with surgically confirmed otosclerosis. MAIN OUTCOME MEASURES: Questionnaire data documented family history of otosclerosis, age of onset, medical history, and information on associated risk factors for 657 patients. Pre and post-surgical pure-tone audiometry was collected for 154 of these patients. RESULTS: The age of onset, incidence of bilateral disease, tinnitus and vertigo, a higher prevalence of women (65%) than men (35%) are similar to those reported previously for otosclerosis cohorts. No association with measles infection was detected. Patients with a family history (40%) have an earlier age of onset and a higher incidence of bilateral disease and vertigo than non-familial subjects. Pedigree analysis is consistent with an autosomal dominant inheritance with reduced penetrance being apparent in 44/91 pedigrees studied. Women who associate their hearing loss with pregnancy have an earlier age of onset than those that do not (p = 6 × 10). CONCLUSIONS: This study confirms that otosclerosis is an early adult onset disease that is more prevalent in women than men with a large minority of patients having a family history of otosclerosis. We report new evidence to support a relationship between pregnancy and otosclerosis progression in a proportion of women. In addition, this is the first study to identify differences in severity between familial and non-familial cases of otosclerosis, highlighting the possibility that more than one etiology may be involved. PMID: 30540696 [PubMed - in process]

p53 regulates CD46 expression and measles virus infection in myeloma cells.

Related Articles p53 regulates CD46 expression and measles virus infection in myeloma cells. Blood Adv. 2018 Dec 11;2(23):3492-3505 Authors: Lok A, Descamps G, Tessoulin B, Chiron D, Eveillard M, Godon C, Le Bris Y, Vabret A, Bellanger C, Maillet L, Barillé-Nion S, Gregoire M, Fonteneau JF, Le Gouill S, Moreau P, Tangy F, Amiot M, Moreau-Aubry A, Pellat-Deceunynck C Abstract In this study, we assessed the sensitivity of myeloma cells to the oncolytic measles virus (MV) in relation to p53 using 37 cell lines and 23 primary samples. We showed that infection and cell death were correlated with CD46 expression, which was associated with TP53 status; TP53 abn cell lines highly expressed CD46 and were preferentially infected by MV when compared with the TP53 wt cell lines (P = .046 and P = .045, respectively). Infection of myeloma cells was fully dependent on CD46 expression in both cell lines and primary cells. In the TP53 wt cell lines, but not the TP53 abn cell lines, activation of the p53 pathway with nutlin3a inhibited both CD46 expression and MV infection, while TP53 silencing reciprocally increased CD46 expression and MV infection. We showed using a p53 chromatin immunoprecipitation assay and microRNA assessment that CD46 gene expression was directly and indirectly regulated by p53. Primary myeloma cells overexpressed CD46 as compared with normal cells and were highly infected and killed by MV. CD46 expression and MV infection were inhibited by nutlin3a in primary p53-competent myeloma cells, but not in p53-deficient myeloma cells, and the latter were highly sensitive to MV infection. In summary, myeloma cells were highly sensitive to MV and infection inhibition by the p53 pathway was abrogated in p53-deficient myeloma cells. These results argue for an MV-based clinical trial for patients with p53 deficiency. PMID: 30530776 [PubMed - in process]

Stochastic Periodic Solution of a Susceptible-Infective Epidemic Model in a Polluted Environment under Environmental Fluctuation.

Related Articles Stochastic Periodic Solution of a Susceptible-Infective Epidemic Model in a Polluted Environment under Environmental Fluctuation. Comput Math Methods Med. 2018;2018:7360685 Authors: Zhao Y, Li J, Ma X Abstract It is well known that the pollution and environmental fluctuations may seriously affect the outbreak of infectious diseases (e.g., measles). Therefore, understanding the association between the periodic outbreak of an infectious disease and noise and pollution still needs further development. Here we consider a stochastic susceptible-infective (SI) epidemic model in a polluted environment, which incorporates both environmental fluctuations as well as pollution. First, the existence of the global positive solution is discussed. Thereafter, the sufficient conditions for the nontrivial stochastic periodic solution and the boundary periodic solution of disease extinction are derived, respectively. Numerical simulation is also conducted in order to support the theoretical results. Our study shows that (i) large intensity noise may help the control of periodic outbreak of infectious disease; (ii) pollution may significantly affect the peak level of infective population and cause adverse health effects on the exposed population. These results can help increase the understanding of periodic outbreak patterns of infectious diseases. PMID: 29853987 [PubMed - indexed for MEDLINE]

Cytomegaloviruses in a Community of Wild Nonhuman Primates in Taï National Park, Côte D'Ivoire.

Related Articles Cytomegaloviruses in a Community of Wild Nonhuman Primates in Taï National Park, Côte D'Ivoire. Viruses. 2017 12 29;10(1): Authors: Anoh AE, Murthy S, Akoua-Koffi C, Couacy-Hymann E, Leendertz FH, Calvignac-Spencer S, Ehlers B Abstract Cytomegaloviruses (CMVs) are known to infect many mammals, including a number of nonhuman primates (NHPs). However, most data available arose from studies led on captive individuals and little is known about CMV diversity in wild NHPs. Here, we analyzed a community of wild nonhuman primates (seven species) in Taï National Park (TNP), Côte d'Ivoire, with two PCR systems targeting betaherpesviruses. CMV DNA was detected in 17/87 primates (4/7 species). Six novel CMVs were identified in sooty mangabeys, Campbell's monkeys and Diana monkeys, respectively. In 3/17 positive individuals (from three NHP species), different CMVs were co-detected. A major part of the glycoprotein B coding sequences of the novel viruses was amplified and sequenced, and phylogenetic analyses were performed that included three previously discovered CMVs of western red colobus from TNP and published CMVs from other NHP species and geographic locations. We find that, despite this locally intensified sampling, NHP CMVs from TNP are completely host-specific, pinpointing the absence or rarity of cross-species transmission. We also show that on longer timescales the evolution of CMVs is characterized by frequent co-divergence with their hosts, although other processes, including lineage duplication and host switching, also have to be invoked to fully explain their evolutionary relationships. PMID: 29286318 [PubMed - indexed for MEDLINE]
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