Cybermedlife - Therapeutic Actions Measles Infection

Allergic disease and atopic sensitization in children in relation to measles vaccination and measles infection.

Abstract Title: Allergic disease and atopic sensitization in children in relation to measles vaccination and measles infection. Abstract Source: Pediatrics. 2009 Mar;123(3):771-8. PMID: 19255001 Abstract Author(s): Helen Rosenlund, Anna Bergström, Johan S Alm, Jackie Swartz, Annika Scheynius, Marianne van Hage, Kari Johansen, Bert Brunekreef, Erika von Mutius, Markus J Ege, Josef Riedler, Charlotte Braun-Fahrländer, Marco Waser, Göran Pershagen, Article Affiliation: Karolinska Institutet, Institute of Environmental Medicine, Department of Environmental Epidemiology, Box 210, SE-171 77 Stockholm, Sweden. This email address is being protected from spambots. You need JavaScript enabled to view it. Abstract: OBJECTIVE: Our aim was to investigate the role of measles vaccination and measles infection in the development of allergic disease and atopic sensitization. METHODS: A total of 14 893 children were included from the cross-sectional, multicenter Prevention of Allergy-Risk Factors for Sensitization in Children Related to Farming and Anthroposophic Lifestyle study, conducted in 5 European countries (Austria, Germany, the Netherlands, Sweden, and Switzerland). The children were between 5 and 13 years of age and represented farm children, Steiner-school children, and 2 reference groups. Children attending Steiner schools often have an anthroposophic (holistic) lifestyle in which some immunizations are avoided or postponed. Parental questionnaires provided information on exposure and lifestyle factors as well as symptoms and diagnoses in the children. A sample of the children was invited for additional tests, and 4049 children provided a blood sample for immunoglobulin E analyses. Only children with complete information on measles vaccination and infection were included in the analyses (84%). RESULTS: In the whole group of children, atopic sensitization was inversely associated with measles infection, and a similar tendency was seen for measles vaccination. To reduce risks of disease-related modification of exposure, children who reported symptoms of wheezing and/or eczema debuting during first year of life were excluded from some analyses. After this exclusion, inverse associations were observed between measles infection and "any allergic symptom" and "any diagnosis of allergy by a physician." However, no associations were found between measles vaccination and allergic disease. CONCLUSION: Our data suggest that measles infection may protect against allergic disease in children. Article Published Date : Mar 01, 2009
Therapeutic Actions Measles Infection

NCBI pubmed

Implementation and assessment of vaccination programmes: the importance of vaccination sequence for overall health outcomes.

Related Articles Implementation and assessment of vaccination programmes: the importance of vaccination sequence for overall health outcomes. Hum Vaccin Immunother. 2018 Jul 18;: Authors: Fisker AB, Thysen SM Abstract In addition to their effect on the target infections, accumulating evidence indicates that vaccines have non-specific effects. Live measles vaccine (MV) has beneficial NSEs reducing mortality by more than can be explained by preventing measles infection. In contrast, non-live diphtheria-tetanus-pertussis vaccine (DTP) has negative NSEs; in spite of protecting against diphtheria, tetanus and pertussis, it is associated with increased mortality. The most recent vaccine has the strongest effect on child health, and therefore sequence of vaccines is important. There is consistent evidence that DTP with or after MV is associated with increased mortality compared with having MV as the most recent vaccine, but the sequence of vaccines is not considered in the current evaluation and implementation of vaccination programmes. To maximise the impact of current vaccination programmes on child health, increased emphasis should be placed on receiving MV after DTP. Increasing time with live MV as the most recent vaccine through better adherence to the schedule, and modified recommendations for catch-up vaccinations for children who do not follow the recommended schedule are likely to result in improvements in child health. PMID: 30020019 [PubMed - as supplied by publisher]