Cybermedlife - Therapeutic Actions Lifestyle Changes - Positive

Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study.

Abstract Title: Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study. Abstract Source: Int J Food Sci Nutr. 2016 Jun ;67(4):461-9. Epub 2016 Mar 17. PMID: 26983396 Abstract Author(s): Zahra Yari, Mehran Rahimlou, Tannaz Eslamparast, Naser Ebrahimi-Daryani, Hossein Poustchi, Azita Hekmatdoost Article Affiliation: Zahra Yari Abstract: A two-arm randomized open labeled controlled clinical trial was conducted on 50 patients with non-alcoholic fatty liver disease (NAFLD). Participants were assigned to take either a lifestyle modification (LM), or LM +30 g/day brown milled flaxseed for 12 weeks. At the end of the study, body weight, liver enzymes, insulin resistance and hepatic fibrosis and steatosis decreased significantly in both groups (p< 0.05); however, this reduction was significantly greater in those who took flaxseed supplementation (p < 0.05). The significant mean differences were reached in hepatic markers between flaxseed and control group, respectively: ALT [-11.12 compared with -3.7 U/L; P< 0.001], AST [-8.29 compared with -4 U/L; p< 0.001], GGT [-15.7 compared with -2.62 U/L; p < 0.001], fibrosis score [-1.26 compared with -0.77 kPa; p = 0.013] and steatosis score [-47 compared with -15.45 dB/m; p = 0.022]. In conclusion, flaxseed supplementation plus lifestyle modification is more effective than lifestyle modification alone for NAFLD management. Article Published Date : May 31, 2016

Increased telomerase activity and comprehensive lifestyle changes: a pilot study.

Abstract Title: Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Abstract Source: Lancet Oncol. 2008 Nov;9(11):1048-57. Epub 2008 Sep 15. PMID: 18799354 Abstract Author(s): Dean Ornish, Jue Lin, Jennifer Daubenmier, Gerdi Weidner, Elissa Epel, Colleen Kemp, Mark Jesus M Magbanua, Ruth Marlin, Loren Yglecias, Peter R Carroll, Elizabeth H Blackburn Article Affiliation: Department of Medicine, University of California, San Francisco, CA, USA. Abstract: BACKGROUND: Telomeres are protective DNA-protein complexes at the end of linear chromosomes that promote chromosomal stability. Telomere shortness in human beings is emerging as a prognostic marker of disease risk, progression, and premature mortality in many types of cancer, including breast, prostate, colorectal, bladder, head and neck, lung, and renal cell. Telomere shortening is counteracted by the cellular enzyme telomerase. Lifestyle factors known to promote cancer and cardiovascular disease might also adversely affect telomerase function. However, previous studies have not addressed whether improvements in nutrition and lifestyle are associated with increases in telomerase activity. We aimed to assess whether 3 months of intensive lifestyle changes increased telomerase activity in peripheral blood mononuclear cells (PBMC). METHODS: 30 men with biopsy-diagnosed low-risk prostate cancer were asked to make comprehensive lifestyle changes. The primary endpoint was telomerase enzymatic activity per viable cell, measured at baseline and after 3 months. 24 patients had sufficient PBMCs needed for longitudinal analysis. This study is registered on the ClinicalTrials.gov website, number NCT00739791. FINDINGS: PBMC telomerase activity expressed as natural logarithms increased from 2.00 (SD 0.44) to 2.22 (SD 0.49; p=0.031). Raw values of telomerase increased from 8.05 (SD 3.50) standard arbitrary units to 10.38 (SD 6.01) standard arbitrary units. The increases in telomerase activity were significantly associated with decreases in low-density lipoprotein (LDL) cholesterol (r=-0.36, p=0.041) and decreases in psychological distress (r=-0.35, p=0.047). INTERPRETATION: Comprehensive lifestyle changes significantly increase telomerase activity and consequently telomere maintenance capacity in human immune-system cells. Given this finding and the pilot nature of this study, we report these increases in telomerase activity as a significant association rather than inferring causation. Larger randomised controlled trials are warranted to confirm the findings of this study. Article Published Date : Nov 01, 2008
Therapeutic Actions Lifestyle Changes - Positive

NCBI pubmed

[School Agroecology and health-related quality of life to adolescents]

Related Articles [School Agroecology and health-related quality of life to adolescents] Rev Fac Cien Med Univ Nac Cordoba. 2018 06 13;75(2):88-104 Authors: Moyano D, Scándolo MC, Perovic NR Abstract The study aimed to evaluate the contribution of school agroecology to the quality of life related to health of adolescents of a school of Cordoba, Argentina. Feasibility study. It was a study quasi- experimental whit control group carried out in a middle-level public school. The sample consisted of 58 adolescents in the intervention group and 77 in the control group. After the intervention increased consumption of agro-ecological food (from 26% to 74% p<0,05). Changes were detected in acquired knowledge about agroecology in the classroom level going from 37% to 63% (p< 0,05). Positive changes detected in awareness with the environment and relationship (p<0,05). It was evidenced that the implementation of school agroecology can provide resolutive contributions to some of the problems the health related quality of life of adolescents. PMID: 30273532 [PubMed - indexed for MEDLINE]