Cybermedlife - Therapeutic Actions Magnet Therapy

Combination Therapy Comprising a Static Magnetic Field with Contractility Improves Skin Wounds.

Abstract Title: Combination Therapy Comprising a Static Magnetic Field with Contractility Improves Skin Wounds. Abstract Source: Tissue Eng Part A. 2018 Mar 21. Epub 2018 Mar 21. PMID: 29652610 Abstract Author(s): Byeong-Wook Song, Hyunki Hong, Yu Jin Jung, Ju Hyung Lee, Bong-Soo Kim, Hoon-Bum Lee Article Affiliation: Byeong-Wook Song Abstract: Cutaneous wounds can present significant clinical problems because of abnormal healing after deep dermal damage. Despite technical advances in wound care, there are still unmet needs that result from inefficient treatment. In this study, we aimed to improve skin wound healing using a contractibility band with static magnetic field (SMF), termed a Magnetic band (Mb). To examine the effect of the Mb on wound healing, full-thickness 15 mm× 35 mm excision wounds were surgically created on the dorsum of rats. An elastic and contractile band (non-treatment), or one neodymium magnet (Nd-1) or two magnets with an elastic and contractile band (Nd-2) were topically applied to the wound daily and the wound size was measured from day 1 to 7after surgery. Nd-2 showed a significant (95%) reduction in the wound size at day 3. Histological analysis showed that pro-inflammatory cytokine levels were diminished by Nd-2, and granulation tissue and microvessels were increased compared with those in the sham group. During Mb-induced wound healing, apoptosis was significantly reduced and matrix remodeling-related factors were initially regulated. The results suggest that combination therapy comprising an SMF and an elastic and contractile band could be a promising tool to heal cutaneous wounds rapidly. Article Published Date : Mar 20, 2018

A randomized, controlled trial of magnetic therapy for carpal tunnel syndrome.

Abstract Title: A randomized, controlled trial of magnetic therapy for carpal tunnel syndrome. Abstract Source: Muscle Nerve. 2018 Mar 7. Epub 2018 Mar 7. PMID: 29513382 Abstract Author(s): Vanessa Baute, Vahakn S Keskinyan, Erica R Sweeney, Kayla D Bowden, Allison Gordon, Janet Hutchens, Michael S Cartwright Article Affiliation: Vanessa Baute Abstract: INTRODUCTION: Magnet therapy has been proposed as a treatment for neurologic conditions. In this this trial we assessed the feasibility and efficacy of a magnet inserted into a wristband for carpal tunnel syndrome (CTS). METHODS: Twenty-two patients with mild to moderate CTS were randomized to wear a high-dose or low-dose"sham"magnetic wristband for 6 weeks. The primary outcome was the Symptom Severity Scale (SSS) of the Boston Carpal Tunnel Questionnaire. Secondary measures were nerve conduction studies (NCS), median nerve ultrasound, and compliance. RESULTS: Compliance for both groups was>90%. Improvements in the mean SSS, NCS, and median nerve ultrasound did not reach statistical significance. DISCUSSION: Magnet therapy via wristband is well-tolerated. Further investigations in larger populations are needed to determine efficacy. Muscle Nerve, 2018. Article Published Date : Mar 06, 2018

Nonpharmacological Treatments for Post-Stroke Depression: An Integrative Review of the Literature.

Abstract Title: Nonpharmacological Treatments for Post-Stroke Depression: An Integrative Review of the Literature. Abstract Source: Res Gerontol Nurs. 2017 May 30:1-14. Epub 2017 May 30. PMID: 28556875 Abstract Author(s): Niloufar Niakosari Hadidi, Roberta L Huna Wagner, Ruth Lindquist Article Affiliation: Niloufar Niakosari Hadidi Abstract: Stroke is the fifth leading cause of death and the number one cause of long-term disability. Seventy-five percent of annual stroke victims are older than 65. Post-stroke depression (PSD) is a common consequence of stroke, with the estimated prevalence ranging from 25% to 79%. Although several studies have investigated the impact of pharmacological interventions on PSD, there is a significant gap in knowledge regarding the efficacy of nonpharmacological measures for treatment of PSD. The purpose of the current integrative literature review was to synthesize the state of knowledge on selected nonpharmacological treatments for PSD and present findings regarding the efficacy of investigated treatments. Twenty-one studies published from 1992-2016 were identified and synthesized. Results indicated that studies demonstrating improvement in depressive symptoms included ecosystem-focused therapy, life review therapy, problem solving therapy, meridian acupressure, repetitive transcranial magnetic stimulation, music therapy, exercise, light therapy, motivational interviewing, and robotic-assisted neurorehabilitation. [Res Gerontol Nurs. 2017; x(x):xx-xx.]. Article Published Date : May 29, 2017

Augmenting melodic intonation therapy with non-invasive brain stimulation to treat impaired left-hemisphere function: two case studies. 📎

Abstract Title: Augmenting melodic intonation therapy with non-invasive brain stimulation to treat impaired left-hemisphere function: two case studies. Abstract Source: Front Psychol. 2014 ;5:37. Epub 2014 Feb 4. PMID: 24550864 Abstract Author(s): Shahd Al-Janabi, Lyndsey A Nickels, Paul F Sowman, Hana Burianová, Dawn L Merrett, William F Thompson Article Affiliation: Shahd Al-Janabi Abstract: The purpose of this study was to investigate whether or not the right hemisphere can be engaged using Melodic Intonation Therapy (MIT) and excitatory repetitive transcranial magnetic stimulation (rTMS) to improve language function in people with aphasia. The two participants in this study (GOE and AMC) have chronic non-fluent aphasia. A functional Magnetic Resonance Imaging (fMRI) task was used to localize the right Broca's homolog area in the inferior frontal gyrus for rTMS coil placement. The treatment protocol included an rTMS phase, which consisted of 3 treatment sessions that used an excitatory stimulation method known as intermittent theta burst stimulation, and a sham-rTMS phase, which consisted of 3 treatment sessions that used a sham coil. Each treatment session was followed by 40 min of MIT. A linguistic battery was administered after each session. Our findings show that one participant, GOE, improved in verbal fluency and the repetition of phrases when treated with MIT in combination with TMS. However, AMC showed no evidence of behavioral benefit from this brief treatment trial. Post-treatment neural activity changes were observed for both participants in the left Broca's area and right Broca's homolog. These case studies indicate that a combination of MIT and rTMS applied to the right Broca's homolog has the potential to improve speech and language outcomes for at least some people with post-stroke aphasia. Article Published Date : Dec 31, 2013

Transcranial magneto- and electrostimulation in patients with obesity and erectile dysfunction

Abstract Title: [Transcranial magneto- and electrostimulation in patients with obesity and erectile dysfunction]. Abstract Source: Vopr Kurortol Fizioter Lech Fiz Kult. 2009 Sep-Oct(5):30-3. PMID: 19886019 Abstract Author(s): G N Ponomarenko, T G Bin'iash, Iu M Raĭgorodskiĭ, A S Guliaev, V A Shul'diakov, A M Kiriliuk, L Iu Vartanova Abstract: The objective of the present study was to evaluate therapeutic efficiency of transcranial magnetotherapy (TcMT) and electric stimulation (ES) included in the combined treatment of 143 patients with erectile dysfunction (ED) and abdominal obesity. The majority of the patients had waist circumference over 102 cm. An AMO-ATOS complex was used to stimulate the hypothalamic region and other brain structures. Transdermal myostimulation of the abdominal and femoral regions was achieved with a Miovolna device. It was shown that both TcM and ES improved lipid metabolism and erectile function; moreover, they exerted hypotensive and sedative action. Specifically, the testosterone level in the patients increased by a mean of 27% compared with the pre-treatment values while the number of patients complaining of erectile dysfunction decreased by 31%. Article Published Date : Sep 01, 2009

Effects of low frequency repetitive transcranial magnetic stimulation (rTMS) on gamma frequency oscillations and event-related potentials during processing of illusory figures in autism.

Abstract Title: Effects of low frequency repetitive transcranial magnetic stimulation (rTMS) on gamma frequency oscillations and event-related potentials during processing of illusory figures in autism. Abstract Source: Lab Invest. 2008 May;88(5):529-40. Epub 2008 Mar 10. PMID: 19030976 Abstract Author(s): Estate M Sokhadze, Ayman El-Baz, Joshua Baruth, Grace Mathai, Lonnie Sears, Manuel F Casanova Abstract: Previous studies by our group suggest that the neuropathology of autism is characterized by a disturbance of cortical modularity. In this model a decrease in the peripheral neuropil space of affected minicolumns provides for an inhibitory deficit and a readjustment in their signal to noise bias during information processing. In this study we proposed using low frequency transcranial magnetic stimulation (rTMS) as a way increasing the surround inhibition of minicolumns in autism. Thirteen patients (ADOS and ADI-R diagnosed) and equal number of controls participated in the study. Repetitive TMS was delivered at 0.5 Hz, 2 times per week for 3 weeks. Outcome measures based on event-related potentials (ERP), induced gamma activity, and behavioral measures showed significant post-TMS improvement. The results suggest that rTMS offers a potential therapeutic intervention for autism. Article Published Date : May 01, 2008

Low intensity permanent magnets in the treatment of chronic lumbar radicular pain.

Abstract Title: Low intensity permanent magnets in the treatment of chronic lumbar radicular pain. Abstract Source: J Pain Symptom Manage. 2007 Oct;34(4):434-45. Epub 2007 Jul 9. PMID: 17618081 Abstract Author(s): Suzan Khoromi, Marc R Blackman, Albert Kingman, Athos Patsalides, Leigh Ann Matheny, Sandra Adams, Arthur A Pilla, Mitchell B Max Abstract: We assessed the pain-relieving efficacy of static magnetic fields produced by 200 Gauss (G) magnets compared with 50G magnets in a double-blind, randomized, two-phase crossover study in patients with chronic lumbar radicular pain. The surface field strengths of the magnets were 200 and 50G. Phase I included four random periods of two-week duration: two periods with 200G, one period with 50G, and one period of "no treatment." The magnets were positioned either vertically or horizontally in standard lumbosacral elastic corsets. Phase II consisted of two five-week periods with the most effective magnet from Phase I and its corresponding 50 or 200G device. The primary outcome was average daily leg pain score (0-10 scale) in each period of Phase II. Thirty-eight of 40 randomized patients completed Phase I, and 28 of 31 Phase II participants completed the study. In Phase I, pain scores did not differ significantly between 200 and 50G magnets. Phase II average leg pain scores tended to be lower with 200 vs. 50G magnets (3.2+/-2.1 for 200G vs. 3.9+/-2.2 for 50G magnets [P=0.08]) after excluding one unblinded patient. The relative treatment effect of the 200G magnets appeared to increase throughout the five-week period. Although these data cannot rule out a chance effect, the positive trends suggest that larger, longer-duration, sham-controlled trials with 200G magnets be considered in patients with chronic lumbar radicular pain. Article Published Date : Oct 01, 2007

Symptom change in women with overactive bladder after extracorporeal magnetic stimulation: a prospective trial.

Abstract Title: Symptom change in women with overactive bladder after extracorporeal magnetic stimulation: a prospective trial. Abstract Source: Int Urogynecol J Pelvic Floor Dysfunct. 2007 Aug;18(8):875-80. Epub 2006 Nov 30. PMID: 17136485 Abstract Author(s): Jin Ho Choe, Myung-Soo Choo, Kyu-Sung Lee Abstract: The purpose of this study was to prospectively evaluate symptom change after discontinuation of extracorporeal magnetic stimulation (EMS) in women with overactive bladder (OAB). A total of 48 women with OAB were included. We applied 10 Hz of repetitive magnetic stimulation with a "magnetic chair" for 20 min, twice weekly for 8 weeks. Changes in OAB symptoms at 2, 12, and 24 weeks after discontinuing the EMS were evaluated. Twenty-seven (56.3%) patients were cured compared with the baseline at 2 weeks: the cure rate was determined as 68.8% (33/48 patients), 56.3% (27/48), and 50% (8/16) for urgency, frequency, and urge incontinence, respectively. The mean number of voids per 24 h was decreased by 42.8% (from 14.5 +/- 4.3, to 8.3 +/- 1.5, P<0.001) at 2 weeks after treatment. Maximum voided volume did not change significantly, but the mean voided volume increased significantly after stimulation. Twenty-six (96.3%) patients among the 27 patients who achieved a cure at 2 weeks, maintained improvement at 24 weeks; the therapeutic effect on urgency, frequency, and urge incontinence persisted in 26 (78.8%) of 33 patients, 26 (96.3%) of 27 patients, and six (75%) of eight patients, respectively. There were no significant changes in urodynamic parameters. Of the 14 patients with detrusor overactivity, the condition was no longer observed in four (28.6%) patients. EMS has a beneficial effect on women with OAB. Our data suggest EMS may have a significant carry-over effect in well-selected OAB patients. Article Published Date : Aug 01, 2007

Bone healing and biochemical blood parameters after arteficial osteotomy of rabbits' femur treated by low-frequency magnetic field

Abstract Title: [Bone healing and biochemical blood parameters after arteficial osteotomy of rabbits' femur treated by low-frequency magnetic field]. Abstract Source: Radiat Res. 2006 May;165(5):546-52. PMID: 15503621 Abstract Author(s): Z Turk Abstract: Aim of the study was to investigate the effect of magnetic fields on bone fracture healing and biochemical indices of bone turnover. Young male "White Newzealand Rabbits" were exposed after osteotomy of the femur of the hind-paw in narcosis for 31 days in a low-frequency magnetic field (field parameters: frequency 15.3 Hz, signal form: sine, magnetic field strength: 50 microT peak value). Eight animals each were assigned randomly for a single blind study to 3 groups. Controls were kept in a sham-exposition cage without magnetic field influence and were compared with a group in (Pseudo-) Helmholtz-coil arrangement with a horizontal magnetic field and a further group in a cylinder coil (vertical magnetic field). The daily duration of stay in the (sham-) exposition arrangements amounted to 30 minutes respectively. The activities of the alkaline phosphatase (AP) and creatinkinase (CK) were evaluated preoperatively, after the 19th and 31st experimental day, the callus density by means of computertomography after the 31st experimental day (two-tailed t-test). The densitometrically assessed callus densities of the magnetically treated groups were highly significant (p < 0.0001) compared with the controls. In spite of accelerated fracture healing the activities of the ALP were lower at both postoperative examinations than preoperatively, in the cylinder-coil the activity proved to be significantly lower (p < 0.05) compared with the controls after 31 days. Significant differences in CK were detected at no time. In conclusion, we confirm the positive magnetic field effects on fracture healing. The mechanisms of interaction of magnetic field and bone fracture healing remain to be clarified. Article Published Date : May 01, 2006

Effects of therapeutic magnetic stimulation on acute muscle atrophy in rats after hindlimb suspension. 📎

Abstract Title: Effects of therapeutic magnetic stimulation on acute muscle atrophy in rats after hindlimb suspension. Abstract Source: Biomed Res. 2006 Feb;27(1):23-7. PMID: 16543662 Abstract Author(s): Yoichi Shimada, Tsutomu Sakuraba, Toshiki Matsunaga, Akiko Misawa, Masahito Kawatani, Eiji Itoi Abstract: In most subjects with spinal cord injury, the spinal neurons below the level of injury are spared. Therefore, it is conceivable that the skeletal muscles innervated by these spinal nerves can be activated by applying therapeutic magnetic stimulation along the dorsal spine. The purpose of this study was to evaluate the ability of magnetic stimulation to prevent acute muscle atrophy in rats after hindlimb suspension. Forty adult male Wistar rats were randomly assigned to stimulated and non-stimulated (control) groups. Their hindlimbs were unweighted using a suspension method, causing muscle atrophy. In the stimulation group, magnetic stimulation (20 Hz, 60 min per day) was applied to the sciatic nerve for 10 days. After the stimulation period, the tibialis anterior (TA) and extensor digitorum longus (EDL) were surgically removed and histologically measured. The lesser diameters of type 1, 2A, and 2B muscle fibers were significantly greater in the stimulated group than in the non-stimulated group for both the TA and EDL (p < 0.05). The mean difference in lesser fiber diameter was 20% (range, 14%-27%). These results suggest that therapeutic magnetic stimulation is an effective method of preventing muscle atrophy. Article Published Date : Feb 01, 2006
Therapeutic Actions Magnet Therapy

NCBI pubmed

Magnetic delivery of Fe3O4@polydopamine nanoparticle-loaded natural killer cells suggest a promising anticancer treatment.

Related Articles Magnetic delivery of Fe3O4@polydopamine nanoparticle-loaded natural killer cells suggest a promising anticancer treatment. Biomater Sci. 2018 Sep 25;6(10):2714-2725 Authors: Wu L, Zhang F, Wei Z, Li X, Zhao H, Lv H, Ge R, Ma H, Zhang H, Yang B, Li J, Jiang J Abstract Natural killer (NK)-cell-based immunotherapy has been reported to have promising prospects in the treatment of non-small cell lung cancer, one of the most common malignancies in the world. It has been proven that higher the NK cell infiltration into the tumor, the better is the curative effect. Therefore, it would be beneficial to develop a method that increases NK cell recruitment and infiltration into the tumor site. The purpose of this study was to establish an immune-cell delivery system for clear lung cancer cells based on magnetic nanoparticle (NP)-labeled NK cells that can be accumulated at the tumor site by placing a tiny external magnetic device inside animals. We developed superparamagnetic iron oxide NPs consisting of a magnetic Fe3O4 core and a shell of polydopamine (PDA) for magnetic targeting therapy. Fe3O4@PDA NPs possess favorable physiological stability and biocompatibility that facilitate their active uptake by NK cells. The biology of NK cells was not affected by the presence of NPs. In vitro and in vivo studies showed that Fe3O4@PDA NP-labeled NK cells significantly inhibited tumor growth and reduced the expression of Ki-67 and increased the apoptosis of A549 cancer cells. H&E staining showed Fe3O4@PDA NP-labeled NK cells, under a magnetic field, had higher intra-tumoral iron density and increased accumulation of CD56+ NK cells. Our results suggest that Fe3O4@PDA NPs are a promising magnetic nanomaterial that can manipulate immune cells, thereby inhibiting tumor growth. PMID: 30151523 [PubMed - indexed for MEDLINE]

Split Cas9, Not Hairs - Advancing the Therapeutic Index of CRISPR Technology.

Related Articles Split Cas9, Not Hairs - Advancing the Therapeutic Index of CRISPR Technology. Biotechnol J. 2018 Sep;13(9):e1700432 Authors: Schmelas C, Grimm D Abstract The discovery that the bacterial CRISPR/Cas9 system can be translated into mammalian cells continues to have an unprecedented impact on the biomedical research community, as it largely facilitates efforts to experimentally interrogate or therapeutically modify the cellular genome. In particular, CRISPR promises the ability to correct disease-associated genetic defects, or to target and destroy invading foreign DNA, in a simple, efficient, and selective manner directly in affected human cells or tissues. Here, we highlight a set of exciting new strategies that aim at further increasing the therapeutic index of CRISPR technologies, by reducing the size of Cas9 expression cassettes and thus enhancing their compatibility with viral gene delivery vectors. Specifically, we discuss the concept of splitCas9 whereby the Cas9 holo-protein is segregated into two parts that are expressed individually and reunited in the cell by various means, including use of 1) the gRNA as a scaffold for Cas9 assembly; 2) the rapamycin-controlled FKBP/FRB system; 3) the light-regulated Magnet system; or 4) inteins. We describe how these avenues, despite pursuing the identical aim, differ in critical features comprising the extent of spatio-temporal control of CRISPR activity, and discuss additional improvements to their efficiency or specificity that should foster their clinical translation. PMID: 29316283 [PubMed - indexed for MEDLINE]

[Transhepatic arterial embolization with superparamagnetic iron oxide and lipiodol for the treatment of VX2 tumor in rabbits].

Related Articles [Transhepatic arterial embolization with superparamagnetic iron oxide and lipiodol for the treatment of VX2 tumor in rabbits]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Nov 28;42(11):1248-1256 Authors: Liang Q, Deng L, Feng Z, Liu X, Ding J, Hu P, Wang W Abstract OBJECTIVE: To evaluate the feasibility and therapeutic efficacy of transhepatic arterial embolization with superparamagnetic iron oxide (SPIO) and lipiodol (LIP) for the treatment of VX2 tumor in rabbits.
 Methods: Twenty-four rabbits with hepatic VX2 tumors by surgical implantation were randomly divided into 4 groups and treated with transhepatic arterial embolization of 4 different agents as follows (n=6 each): doxorubicin (DOX) group, DOX-LIP group, SPIO-DOX group, and SPIO-DOX-LIP group. Liver function (AST and ALT) was measured at 0, 1, 3, 5 and 7 d after transhepatic arterial embolization. The serum DOX level was measured at 0, 5, 15, 30, 60, and 120 minutes after transhepatic arterial embolization. MRI was performed at 7 d after the treatment to assess the distribution of SPIO in the SPIO-DOX group and SPIO-DOX-LIP group, while CT was performed to assess the distribution of LIP in the DOX-LIP group and SPIO-DOX-LIP group. All the rabbits were sacrificed and their livers were removed at 7 d after treatment for the detection of tissue DOX level. The histopathologic examinations were performed including HE staining, Prussian blue staining and TUNEL assay, and then the tumor necrosis percentage and apoptosis index were calculated.
 Results: Compared to the DOX group, the levels of AST and ALT in other 3 groups were significantly elevated at 1 and 3 d after embolization (P<0.05). The levels of ALT and AST in the DOX group, DOX-LIP group or SPIO-DOX-LIP group returned to the baseline at day 7, there were no significant differences (P>0.05). The SPIO-DOX-LIP group exhibited the lowest serum DOX level at all time points up to 120 minutes after embolization (P<0.05). However, the tissue DOX level in the SPIO-DOX-LIP group was the highest among all groups at day 7 (P<0.05). The SPIO-DOX group and SPIO-DOX-LIP group showed significantly lower MRI signal intensity of tumors in T2 weighted imaging (T2WI) at day 7. Meanwhile DOX-LIP group and SPIO-DOX-LIP group showed that high-density lipiodol was deposited in the tumors in CT images. Histopathologic findings showed an almost complete central necrosis coagulation of tumors in the SPIO-DOX-LIP group, and the tumor necrosis percentage and tumor apoptosis index were significantly increased in the SPIO-DOX-LIP group compared to those in other 3 groups (P<0.05).
 Conclusion: This novel drug-delivery system of SPIO nano-drug carrier together with LIP is safe and feasible when it is used for transhepatic arterial embolization for liver tumor. It provides an excellent MR and CT visualization and improves the therapeutic efficacy for the treatment of rabbit VX2 liver tumor. PMID: 29187650 [PubMed - indexed for MEDLINE]

Synergistically enhanced selective intracellular uptake of anticancer drug carrier comprising folic acid-conjugated hydrogels containing magnetite nanoparticles.

Related Articles Synergistically enhanced selective intracellular uptake of anticancer drug carrier comprising folic acid-conjugated hydrogels containing magnetite nanoparticles. Sci Rep. 2017 01 20;7:41090 Authors: Kim H, Jo A, Baek S, Lim D, Park SY, Cho SK, Chung JW, Yoon J Abstract Targeted drug delivery has long been extensively researched since drug delivery and release at the diseased site with minimum dosage realizes the effective therapy without adverse side effects. In this work, to achieve enhanced intracellular uptake of anticancer drug carriers for efficient chemo-therapy, we have designed targeted multifunctional anticancer drug carrier hydrogels. Temperature-responsive poly(N-isopropylacrylamide) (PNIPAm) hydrogel core containing superparamagnetic magnetite nanoparticles (MNP) were prepared using precipitation polymerization, and further polymerized with amine-functionalized copolymer shell to facilitate the conjugation of targeting ligand. Then, folic acid, specific targeting ligand for cervical cancer cell line (HeLa), was conjugated on the hydrogel surface, yielding the ligand conjugated hybrid hydrogels. We revealed that enhanced intracellular uptake by HeLa cells in vitro was enabled by both magnetic attraction and receptor-mediated endocytosis, which were contributed by MNP and folic acid, respectively. Furthermore, site-specific uptake of the developed carrier was confirmed by incubating with several other cell lines. Based on synergistically enhanced intracellular uptake, efficient cytotoxicity and apoptotic activity of HeLa cells incubated with anticancer drug loaded hybrid hydrogels were successfully achieved. The developed dual-targeted hybrid hydrogels are expected to provide a platform for the next generation intelligent drug delivery systems. PMID: 28106163 [PubMed - indexed for MEDLINE]