Functionalized electromagnetic actuation method for aggregated nanoparticles steering.
Conf Proc IEEE Eng Med Biol Soc. 2017 07;2017:885-888
Authors: Hoshiar AK, Tuan-Anh Le, Amin FU, Myeong Ok Kim, Jungwon Yoon
Despite the promising results in magnetic nanoparticles (MNPs) based targeted drug delivery (TDD), the aggregation of the magnetic nanoparticles deteriorates targeting performance. This paper aims to introduce a magnetic actuation function for aggregated nanoparticles steering in vascular network. To improve the drug delivery performance, first the governing dynamics has been introduced, next the modified field function (MFF) concept has been proposed and finally a computational platform for a Y-shape channel has been used to simulate the particles steering performance. The results showed an acceptable agreement with the experimental results. The proposed actuation method enables us to more accurately steer aggregated nanoparticles and improves targeting performance.
PMID: 29060014 [PubMed - indexed for MEDLINE]
Evaluation of folic acid tagged aminated starch/ZnO coated iron oxide nanoparticles as targeted curcumin delivery system.
Carbohydr Polym. 2017 Feb 10;157:391-399
Authors: Saikia C, Das MK, Ramteke A, Maji TK
The role of 'superparamagnetic iron oxide nanoparticles' has gained considerable interest in various biomedical applications. However extensive researches are still going on to modify the nanoparticle size, surface properties etc. in order to get full benefit of the material. In this study, iron oxide nanoparticles have been modified with folic acid tagged aminated starch/ZnO coating to formulate a targeted drug delivery system. The nanoparticles were characterized by Fourier Transform Infra-red Spectroscopy, X-ray Diffraction, Scanning Electron Microscopy and Transmission Electron Microscopy. Both the swelling and in vitro drug release was performed in both acidic and alkaline pH. The cytotoxicity of the drug loaded nanoparticles was analysed by MTT assay in human lymphocytes, HepG2 and MCF7 cell lines. The cell uptake efficiencies and Reactive Oxygen Species generation with the drug loaded nanoparticles was estimated in HepG2 cell lines. The uptake capacity of fluorescein isothiocyanate tagged nanoparticles was assessed by fluorescence microscope.
PMID: 27987943 [PubMed - indexed for MEDLINE]