CYBERMED LIFE - ORGANIC  & NATURAL LIVING

Cybermedlife - Therapeutic Actions Moxibustion

Electroacupuncture and moxibustion promote regeneration of injured sciatic nerve through Schwann cell proliferation and nerve growth factor secretion. 📎

Abstract Title: Electroacupuncture and moxibustion promote regeneration of injured sciatic nerve through Schwann cell proliferation and nerve growth factor secretion. Abstract Source: Neural Regen Res. 2018 Mar ;13(3):477-483. PMID: 29623933 Abstract Author(s): Lin-Na Hu, Jin-Xin Tian, Wei Gao, Jing Zhu, Fang-Fang Mou, Xiao-Chun Ye, Yu-Pu Liu, Ping-Ping Lu, Shui-Jin Shao, Hai-Dong Guo Article Affiliation: Lin-Na Hu Abstract: Using electroacupuncture and moxibustion to treat peripheral nerve injury is highly efficient with low side effects. However, the electroacupuncture- and moxibustion-based mechanisms underlying nerve repair are still unclear. Here, in vivo and in vitro experiments uncovered one mechanism through which electroacupuncture and moxibustion affect regeneration after peripheral nerve injury. We first established rat models of sciatic nerve injury using neurotomy. Rats were treated with electroacupuncture or moxibustion at acupoints Huantiao (GB30) and Zusanli (ST36). Each treatment lasted 15 minutes, and treatments were given six times a week for 4 consecutive weeks. Behavioral testing was used to determine the sciatic functional index. We used electrophysiological detection to measure sciatic nerve conduction velocity and performed hematoxylin-eosin staining to determine any changes in the gastrocnemius muscle. We used immunohistochemistry to observe changes in the expression of S100-a specific marker for Schwann cells-and an enzyme-linked immunosorbent assay to detect serum level of nerve growth factor. Results showed that compared with the model-only group, sciatic functional index, recovery rate of conduction velocity, diameter recovery of the gastrocnemius muscle fibers, number of S100-immunoreactive cells, and level of nerve growth factor were greater in the electroacupuncture and moxibustion groups. The efficacy did not differ between treatment groups. The serum from treated rats was collected and used to stimulate Schwann cells cultured in vitro. Results showed that the viability of Schwann cells was much higher in the treatment groups than in the model group at 3 and 5 days after treatment. These findings indicate that electroacupuncture and moxibustion promoted nerve regeneration and functional recovery; its mechanism might be associated with the enhancement of Schwann cell proliferation and upregulation of nerve growth factor. Article Published Date : Feb 28, 2018

Improvement of survival quality of the patients with hemodialysis treated with moxibustion for regulating spleen and stomach functions: multi-central randomized controlled study

Abstract Title: [Improvement of survival quality of the patients with hemodialysis treated with moxibustion for regulating spleen and stomach functions: multi-central randomized controlled study]. Abstract Source: Zhongguo Zhen Jiu. 2014 Apr ;34(4):319-24. PMID: 24946626 Abstract Author(s): Shao-Hua Wang, Mo-Yan Qiu, Ai-Hua Cheng, Nan Li, Yan-Ming Xie, Jian-Rong Hao, Qi-Meng Zhang, Jie Luan, Peng Liu, Er-Ping Yan, Jin-Chen Fu, Zong-Yang Yu, Li Zhu, Peng Tian Article Affiliation: Shao-Hua Wang Abstract: OBJECTIVE: To discuss the impacts of moxibustion for regulating spleen and stomach function on the survival quality of the patients of end stage renal disease (ESRD) with maintenance hemodialysis (MHD). METHODS: One hundred and nine cases of uremia with MHD from 3 hemodialysis centers were randomized into an observation group (58 cases) and a control group (51 cases). The regular hemodialysis and conventional medication were used in the two groups. In the observation group, on the basis of the common treatment, moxibustion was applied to Zusanli (ST 36) and Sanyinjiao (SP 6), 2-3 times a day, the treatment of 4 weeks made one session. Totally, 3 sessions were required and the follow-up lasted for 3 months. KDQOL-SF (kidney disease quality of life short form,KDQOL-SFTM 1. 3) was adopted for the questionnaire investigation on survival quality before treatment, after treatment and at the end of follow-up separately in the two groups. RESULTS: After treatment, the survival quality scores in terms of physical functioning (83.62+/-13.27 vs 79.32+/- 22. 17), general health (58. 88+/- 20.24 vs 48.82+/-20.89) and vitality (77.07+/-15.56 vs 70. 59+/-22.61) in the observation group were higher than those in the control group (all P<0. 05). In comparison before and after treatment in the same group, the survival quality scores in terms of physical functioning, general health, vitality and symptoms/problems were all improved in the observation group (all P<0. 05). At the end of follow-up, the survival quality scores in terms of physical functioning, general health, mental health, social functioning, vitality, effects of kidney disease and cognitive function were higher in the observation group as compared with those in the control group (all P<0. 05). In comparison of the results at the end of follow-up with those before treatment, the survival quality scores in terms of vitality, symptoms/problems and cognitive function in the observation group were improved (all P<0. 05). The differences were not significant in all of the 19 fields of survival quality evaluation before and after treatment, and after follow-up in the control group (all P>0. 05). CONCLUSION: Moxibustion for regulating spleen and stomach function improves the survival quality of the patients with hemodialysis in terms of physical functioning, general health and vitality, which benefits the psychological condition of the patients, resulting in the improvements of the survival quality in the fields of mental health, social functioning, effects of kidney disease and cognitive function. Article Published Date : Mar 31, 2014

Effectiveness of moxibustion treatment as adjunctive therapy in osteoarthritis of the knee: a randomized, double-blinded, placebo-controlled clinical trial. 📎

Abstract Title: Effectiveness of moxibustion treatment as adjunctive therapy in osteoarthritis of the knee: a randomized, double-blinded, placebo-controlled clinical trial. Abstract Source: Arthritis Res Ther. 2014 ;16(3):R133. Epub 2014 Jun 24. PMID: 24962039 Abstract Author(s): Ling Zhao, Ke Cheng, Lizhen Wang, Fan Wu, Haiping Deng, Ming Tan, Lixing Lao, Xueyong Shen Article Affiliation: Ling Zhao Abstract: INTRODUCTION: Our objective was to compare the effectiveness and safety of traditional Chinese moxibustion to that of sham moxibustion in patients with chronic knee osteoarthritis (KOA) pain. METHODS: We conducted a randomized placebo-controlled trial involving 110 patients with KOA who met the inclusion criteria. These patients randomly received either active moxibustion (n = 55) or sham moxibustion control (n = 55) at acupoints Dubi (ST 35), extra-point Neixiyan (EX-LE 4), and an Ashi (tender) point three times a week for 6 weeks. Effects were evaluated with Western Ontario and McMaster Universities' Osteoarthritis Index (WOMAC VA 3.1) criteria at the end ofthe course of treatment and 3, 12, and 24 weeks after the initial treatment. RESULTS: The WOMAC pain scores showed greater improvement in the active treatment group than in control at weeks 3 (P = 0.012), 6 (P<0.001), 12 (P = 0.002), and 24 (P = 0.002) as did WOMAC physical function scores of the active treatment group at week 3 (P = 0.002), 6 (P = 0.015), and 12 (P<0.001) but not 24 (P = 0.058). Patients and practitioners were blinded successfully, and no significant adverse effects were found during the trial. CONCLUSIONS: A 6-week course of moxibustion seems to relieve pain effectively and improve function in patients with KOA for up to 18 weeks after the end of treatment. Moxibustion treatment appears to be safe, and the usefulness of the novel moxa device was validated. TRIAL REGISTRATION: Current controlled trial: ISRCTN68475405. Registered 4 April 2014. Article Published Date : Dec 31, 2013

Effect on moxibustion at Sanyinjiao (SP 6) for uterine contraction pain in labor: a randomized controlled trial

Abstract Title: [Effect on moxibustion at Sanyinjiao (SP 6) for uterine contraction pain in labor: a randomized controlled trial]. Abstract Source: Zhongguo Zhen Jiu. 2010 Aug;30(8):623-6. PMID: 20942275 Abstract Author(s): Shu-xiang Ma, Fan-wu Wu, Jian-mei Cui, Zi-huan Jin, Ling-jun Kong Article Affiliation: TCM Department, North China Coal Medical University, Tangshan 063000, China. Abstract: OBJECTIVE: To investigate the effect of moxibustion at Sanyinjiao (SP 6) for uterine contraction pain in labor, and evaluate the safety of the parturient and newborn. METHODS: One hundred and seventy-four cases of singleton pregnancy and cephalic presentation primipara were single blinded and randomly divided into three groups: observation group (59 cases), placebo treated group (57 cases) and blank group (58 cases). The observation group was treated with moxibustion at Sanyinjiao (SP 6) for 30 min when the uterus cervix openning at 3 cm, the placebo treated group was treated with moxibustion at no acupoint for 30 min and the blank group was treated with routine labor nursing, the uterine contraction pain and the safety of the mother and infant were compared among three groups. RESULTS: 1) The uterine contraction pain was tested by Visual Analogue Scale (VAS): the scores of VAS in the observation group were obviously decreased after 15 min and 30 min of moxibustion (both P<0.05), there were no obvious changes of the VAS scores in placebo treated group and the blank group, the scores of VAS in observation group decreased much more obviously than those in the other two groups (all P<0.05); 2) Midwife rating of the uterine contraction pain: after 30 min of moxibustion, the effective rate of labor analgesia was 69.5% (41/59) in observation group, which was higher than that of 45.6% (26/57) in placebo treated group and 43.1% (25/58) in blank group, with significant differences between them (both P<0.05); 3) The postpartum hemorrhage amount of the observation group was obviously lower than those of placebo treated group and blank group (both P<0.05); 4) The Apgar score of newborn was higher in observation group and placebo treated group than that of blank group (both P<0.05). CONCLUSION: Moxibustion at Sanyinjiao (SP 6) can relieve the uterine contraction pain, and has no side effect to mother and infant, it is one of the safe, effective and simple non-drug analgesia methods. Article Published Date : Aug 01, 2010

Factors affecting the success of moxibustion in the management of a breech presentation as a preliminary treatment to external cephalic version.

Abstract Title: Factors affecting the success of moxibustion in the management of a breech presentation as a preliminary treatment to external cephalic version. Abstract Source: Immunopharmacol Immunotoxicol. 2010 Mar 17. Epub 2010 Mar 17. PMID: 19853333 Abstract Author(s): Anne Manyande, Christine Grabowska Abstract: OBJECTIVES: to explore the effects of moxibustion treatment, to examine the predictors of its use in causing a breech presentation to spontaneously turn to a cephalic presentation which will result in a vaginal birth (the paper will refer to this as 'successful') and offer external cephalic version (ECV) subsequently after moxibustion treatment when the fetus remains in a breech presentation. DESIGN: a prospective study over a two-year time period from February 2004 until January 2006. PARTICIPANTS: 76 pregnant women from various acupuncture practices in the UK, with a third trimester breech presentation. INTERVENTIONS: the acupuncturist taught the women how to apply moxibustion (sticks of compressed dried herbs-Artemisia vulgaris) treatment at home by stimulating the acupoint on the outer edge at the base of the little toe nail for seven days twice a day (morning and afternoon). If the breech presentation persisted after treatment, ECV was carried out towards the end of the pregnancy. The obstetricians offered this during the routine antenatal hospital visits. FINDINGS: the results show that following treatment with moxibustion, 31 (40.8%) of the breech presentations spontaneously turned to cephalic presentations, and a further 33 (43.4%) breech presentations were turned by ECV. Women who involved other people in the administration of moxibustion were twice as likely to be successful. Multiparous women were also 16% more likely than primiparous women to succeed in achieving a spontaneous version with the use of moxibustion. Fewer side effects reported when using moxibustion were the strongest predictor of successful spontaneous cephalic version with an odds ratio of 12% (p = 0.02). KEY CONCLUSIONS: moxibustion creates a better chance of vaginal birth for expectant mothers. Of the women who were successful in turning their babies using moxibustion, 88% went on to have a normal birth and 12% had a caesarean section. Moxibustion treatment also significantly increases version from a breech presentation to a cephalic presentation where there are fewer side effects reported, if the woman is multiparous and has support during the administration of moxibustion treatment. IMPLICATIONS FOR PRACTICE: moxibustion treatment should be offered to all women with a breech presentation because it is non-invasive and can be self-administered by the woman. It is therefore a simple, cost-effective technique that requires no medical intervention.   Article Published Date : Mar 17, 2010

Forty cases of insomnia treated by suspended moxibustion at Baihui (GV 20). 📎

Abstract Title: Forty cases of insomnia treated by suspended moxibustion at Baihui (GV 20). Abstract Source: J Tradit Chin Med. 2009 Jun;29(2):95-6. PMID: 19663092 Abstract Author(s): Yan-li Ju, Xu Chi, Jian-xin Liu Abstract: OBJECTIVE: To observe the therapeutic effect of suspended moxibustion at Baihui (GV 20) for insomnia. METHODS: 75 cases were divided randomly into two groups, with 40 cases in the treatment group treated by suspended moxibustion over Baihui (GV 20) and 35 cases in the control group treated by oral administration of Estazolam. RESULTS: The difference in therapeutic effect between the two groups was not statistically significant (P > 0.1). CONCLUSION: It was concluded that suspended moxibustion at Baihui (GV 20) is as effective as Estazolam for insomnia. Article Published Date : Jun 01, 2009

Observation on therapeutic effect of moxibustion on temperature-sensitive points for lumbar disc herniation

Abstract Title: [Observation on therapeutic effect of moxibustion on temperature-sensitive points for lumbar disc herniation]. Abstract Source: Zhongguo Zhen Jiu. 2009 May;29(5):382-4. PMID: 19489496 Abstract Author(s): Fu-yu Tang, Cheng-jun Huang, Ri-xin Chen, Min Xu, Bao-xin Liu, Zhu Liang Article Affiliation: Department II of Orthopaedics, Liuzhou Hospital of TCM, Liuzhou 545001, China. This email address is being protected from spambots. You need JavaScript enabled to view it. Abstract: OBJECTIVE: To compare therapeutic effects of traditional moxibustion and moxibustion on temperature-sensitive points for lumbar disc herniation. METHODS: One hundred and twenty cases were randomly divided into a temperature-sensitive point group and a traditional moxibustion group, 60 cases in each group. The temperature-sensitive point group was treated with moxibustion on the temperature-sensitive points in the temperature-sensitive high incidence area such as waist and lower limbs, once each day; the traditional moxibustion group was treated with warming moxibustion at Jiaji (EX-B 2), Ciliao (BL 32), Zhibian (BL 54), Huantiao (GB 30), Weizhong (BL 40), Yanglingquan (GB 34), Kunlun (BI. 60), once each day, 7 days constituting one course. The therapeutic effect and the recurrence rate were observed after one course treatment and six months later. RESULTS: After treatment for one course, the cured-markedly effective rate was 65.00% in the temperature-sensitive point group, superior to 50.0% in the traditional moxibustion group, with a significant difference between the two groups (P<0.05); all effective cases were followed-up for six months, the cured-markedly effective rate and the recurrence rate were 62.3% and 26.4% in the temperature-sensitive point group, and 34.2% and 46.3% in the traditional moxibustion group, the therapeutic effect of the temperature-sensitive point group being superior to the traditional moxibustion group, and the recurrence rate was lower than the traditional moxibustion group (both P<0.05). CONCLUSION: Moxibustion on temperature-sensitive points is a effective therapy for lumbar disc herniation, with stable therapeutic effect and low recurrence rate. Article Published Date : May 01, 2009

Clinical observation on moxibustion combined with intermittent urethral catheterization for treatment of neurogenic vesical dysfunction

Abstract Title: [Clinical observation on moxibustion combined with intermittent urethral catheterization for treatment of neurogenic vesical dysfunction]. Abstract Source: Zhongguo Zhen Jiu. 2009 Feb;29(2):91-4. PMID: 19391528 Abstract Author(s): Xiao-dong Feng, Ya-feng Ren, Da-wen Wei, Cheng-mei Liu Article Affiliation: Rehabilitation Center, The First Affiliated Hospital of Henan College of TCM, Zhengzhou 450000, China. Abstract: OBJECTIVE: To observe the effect of moxibustion combined with intermittent urethral catheterization on vesical function in the patient of neurogenic vesical dysfunction. METHODS: Seventy-six cases were randomly divided into an observation group and a control group, 38 cases in each group. The control group was treated with routine intermittent urethral catheterization and the observation group with the intermittent urethral catheterization and moxibustion on Guanyuan (CV 4), Mingmen (GV 4), Zusanli (ST 36), etc. Changes of residual urine volume, white cell count and the balance state of the urinary bladder were selected as the indexes of therapeutic effect and the therapeutic effects were compared between the two groups. RESULTS: The total effective rate was 97.4% in the observation group and 79.0% in the control group with a significant difference between the two groups (P<0.05); after treatment, there were significant differences between the two groups in the residual urine volume, the bladder volume and the case numbers reaching to the functional balance state of bladder (all P<0.05), and there was no significant difference between the two groups in white cell count change (P>0.05). CONCLUSION: Moxibustion combined with intermittent urethral catheterization can significantly improve vesical function in the patient of neurogenic vesical dysfunction, reducing residual urine volume, increasing volume of bladder, promoting the balance state of vesical function, but it is basically same as intermittent urethral catheterization in prevention of urinary infection and therapeutic effect. Article Published Date : Feb 01, 2009

Influence of garlic moxibustion on the therapeutic effect in re-treatment patients of tuberculosis

Abstract Title: [Influence of garlic moxibustion on the therapeutic effect in re-treatment patients of tuberculosis]. Abstract Source: Zhongguo Zhen Jiu. 2009 Jan;29(1):10-2. PMID: 19186714 Abstract Author(s): Xiu-Ping Zhao, Rui-Xiang Chen, Hong-Qing Lü Abstract: OBJECTIVE: To observe the therapeutic effect of moxibustion in re-treatments patients of tuberculosis. METHODS: Fifty-three cases were randomly divided into an observation group (n = 31) and a control group (n = 22). They were treated with routine chemotherapeutic program of western medicine with garlic moxibustion on main points Feishu (BL 13), Gaohuang (BL 43), Shenzhu (GV 12), etc. added in the observation group. The therapeutic effects were assessed by clinical symptoms and signs, X-ray, CT examination and laboratory indexes. RESULTS: The focus absorbing rate of 87.1% in the observation group was better than 63.6% in the control group (P < 0.05); the rate of bacteria-turned negativity in sputum was 90.5% in the observation group which was better than 56.3% in the control group (P < 0.05); the observation group in improvement of hypodynamia, night sweat and cough was superior to the control group (all P < 0.05). CONCLUSION: Moxibustion can increase the therapeutic effect for the re-treatment patient of tuberculosis. Article Published Date : Jan 01, 2009

Clinically randomized controlled trials of moxibustion with salt in bamboo circle for treatment of periarthritis of shoulder

Abstract Title: [Clinically randomized controlled trials of moxibustion with salt in bamboo circle for treatment of periarthritis of shoulder]. Abstract Source: Zhongguo Zhen Jiu. 2009 Jan;29(1):77-80. PMID: 19186729 Abstract Author(s): Kai-Sheng Xu, Man-Wei Huang, Li-Ying Yao, Jie Chen, Jian Su, Jin-Qing Zheng Abstract: OBJECTIVE: To assess the clinical therapeutic effect of moxibustion with salt in bamboo circle on periarthritis of shoulder. METHODS Eighty-six cases were randomly divided into a salt-moxibustion group and an electroacupuncture group, 43 cases in each group. The salt-moxibustion group was treated by moxibustion with salt in bamboo circle on the part of obvious pain and hot compress moxibustion on its periphery. The electroacupuncture group was treated with electroacupuncture at Jianyu (LI 15), Jianliao (TE 14), Jianzhen (SI 9), etc. After treatment, the analgesic effect and improvement degrees of active function of the shoulder joint were observed and 3 months later they were followed-up. RESULTS: The two therapies had analgesic effect and could improve active function of shoulder joint, but the salt-moxibustion group in the transient analgesic effect and the improvement degree of active function of the shoulder joint was better than the electroacupuncture group (P< 0.01, P < 0.05). Follow-up survey showed good clinical therapeutic effects in the two groups. The effective rates of pain and active function of shoulder joint were 97.7% and 93.0% in the salt-moxibustion group and 93.0% and 88.4% in the electroacupuncture group, respectively, with no significant differences between the two groups. CONCLUSION: Moxibustion with salt in bamboo circle has an obvious therapeutic effect on periarthritis of shoulder, and it has transient analgesic effect and improves active function of shoulder joint, with a stable and long-term therapeutic effect. Article Published Date : Jan 01, 2009

Moxibustion, an alternative therapy, ameliorated disturbed circadian rhythm of plasma arginine vasopressin and urine output in multiple system atrophy. 📎

Abstract Title: Moxibustion, an alternative therapy, ameliorated disturbed circadian rhythm of plasma arginine vasopressin and urine output in multiple system atrophy. Abstract Source: Intern Med. 2007 ;46(13):1015-8. Epub 2007 Jul 2. PMID: 17603243 Abstract Author(s): Ryuji Sakakibara, Eiko Murakami, Akira Katagiri, Sei Hayakawa, Tomoyuki Uchiyama, Tatsuya Yamamoto, Takamichi Hattori Article Affiliation: Ryuji Sakakibara Abstract: Previously no alternative therapy approach has been made to ameliorate disturbed circadian arginine vasopressin rhythm (C-AVP-R) in multiple system atrophy (MSA). A 65-year-old man with MSA showed loss of C-AVP-R and nocturnal polyuria. We performed moxibustion at specific acupuncture points on the bladder and inside the feet, once a day, 3 times a week, for 6 months. After the treatment, his C-AVP-R appeared to be normal, and the nocturnal urine output decreased to 75% (p<0.01). Together with the previous studies, it seems possible that somatic warm stimulation by moxibustion in specific points might have facilitated AVP secretion in this patient. Article Published Date : Dec 31, 2006

Randomized controlled study on ginger-salt-partitioned moxibustion at shenque (CV 8) on urination disorders poststroke

Abstract Title: [Randomized controlled study on ginger-salt-partitioned moxibustion at shenque (CV 8) on urination disorders poststroke]. Abstract Source: Zhongguo Zhen Jiu. 2006 Sep;26(9):621-4. PMID: 17036477 Abstract Author(s): Hui-lin Liu, Lin-peng Wang Article Affiliation: Acupuncture Section, Beijing TCM Hospital Affiliated to Capital Medical University, Beijing 100010, China. This email address is being protected from spambots. You need JavaScript enabled to view it. Abstract: OBJECTIVE: To probe the therapeutic effect and safety of ginger-salt-partitioned moxibustion on urination disorders poststroke. METHODS: Eighty-two cases of cerebral apoplexy, including cerebral infarction and cerebral hemorrhage, with urination disorders induced by neurogenic bladder at restoration stage were randomly divided into a treatment group treated with ginger-salt-partitioned moxibustion at Shenque (CV 8) and routine acupuncture, and a control group treated with routine acupuncture. Thirty-nine cases in the treatment group and 36 cases in the control group completed all treatments. The treatment was given 5 times each week and the therapeutic effects were observed after treatment of 3 consecutive weeks. RESULTS: Ginger-salt-partitioned moxibustion in improvement of mean urination times of each day, mean times to be asked to awaken for the nursing personnel at night, mean times of urgent urinary incontinence at day for the patient, cases-times of urinary incontinence of the patient at night, and increasing degree of urinary incontinence was better than the control group (P<0.01, P<0.05). CONCLUSION: Ginger-salt-partitioned moxibustion is a safe and effective therapy for urination disorders poststroke. Article Published Date : Sep 01, 2006

Effects of moxibustion at Feishu (BL 13) and Gaohuang (BL 43) on expression of TGF-beta1 in the bleomycin -induced pulmonary fibrosis

Abstract Title: [Effects of moxibustion at Feishu (BL 13) and Gaohuang (BL 43) on expression of TGF-beta1 in the bleomycin -induced pulmonary fibrosis]. Abstract Source: Zhongguo Zhen Jiu. 2005 Nov;25(11):790-2. PMID: 16335208 Abstract Author(s): Rong Li, Wen-Jun Li, Yong-Ning Cai, Zhi-Gang Li, Quan'an Luo, Mi-Juan Zhou, Cui-Xia Li, Fu-Hong Li, Ming-Fang Liu Abstract: OBJECTIVE: To explore the mechanism of moxibustion arresting the pulmonary fibrosis and provide experimental basis for prevention and treatment of pulmonary fibrosis with acupuncture and moxibustion. METHODS: One hundred and forty SD rats were randomly assigned to 4 groups: a blank group, a model group, a moxibustion group and a prednisone group, 35 rats in each group. The 3 groups expect the blank group were injected with bleomycin via trachea to induce experimental pulmonary fibrosis model, and 7 days after modeling, they were treated with moxibustion at bilateral Feishu (BL 13) and Gaohuang (BL 43), 3 cones each point, once each day, 10 days constituting one therapeutic course with an interval of one day between courses. After 3 courses, all rats were killed and expressions of TGF-beta1mRNA were detected with PCR method. RESULTS: The content of TGF-beta1mRNA in the pulmonary tissue in the moxibustion group and the prednisone group was significantly lower than the model group (P<0.01), and there was no significant difference between the moxibustion group and the prednisone group (P>0. 05). CONCLUSION: Both moxibustion at Feishu (BL 13) and Gaohuang (BL 43), and prednisone treatment can significantly suppress the expression of TGF-beta1mRNA in the pulmonary tissue in the rat of bleomycin-induced pulmonary fibrosis. Article Published Date : Nov 01, 2005

Observation on therapeutic effect of warming needle moxibustion combined with medicine on 128 cases of myasthenia gravis

Abstract Title: [Observation on therapeutic effect of warming needle moxibustion combined with medicine on 128 cases of myasthenia gravis]. Abstract Source: J Agric Food Chem. 2005 Jun 29;53(13):5479-86. PMID: 16739848 Abstract Author(s): Feng-quan Xu, Hong-xia Li, Tao Huang Abstract: OBJECTIVE: To observe clinical therapeutic effect of warming needle moxibustion combined with medicine on myasthenia gravis. METHODS: One hundred and twenty-eight patients were treated with warming needle moxibustion combined with oral administration of serial preparations of Zhongjiling and intravenous drip of Jiweiling Injectio for one month. RESULTS: Eighty-one cases were cured, 17 cases were basically cured, 12 cases were markedly effective, 11 cases improved and 7 cases were ineffective, with a total effective rate of 94.5%. CONCLUSION: Warming needle moxibustion combined with oral administration of serial preparations of Zhongjiling and intravenous drip of Jiweiling Injectio has a definite therapeutic effect on myasthenia gravis. Article Published Date : Jun 29, 2005

Effects of moxibustion on the expression of cell cycle protein P 16 and retinoblastoma and c-fos in the cerebral cortex of senile mice

Abstract Title: [Effects of moxibustion on the expression of cell cycle protein P 16 and retinoblastoma and c-fos in the cerebral cortex of senile mice]. Abstract Source: Behav Brain Res. 2004 Aug 12;153(1):181-8. PMID: 21090325 Abstract Author(s): Yan Du, Li-Hua Zhao, Hai-Biao Wu, Jin-Sheng Wang Article Affiliation: Department of Acu-moxibustion, the Affiliated Ruikang Hospital of Guangxi College of Chinese Medicine, Nanning 530011, China. This email address is being protected from spambots. You need JavaScript enabled to view it. Abstract: OBJECTIVE: To observe the influence of moxibustion on the cyclin and cellular proliferin of the cerebral cortex in senile mice so as to explore its underlying mechanism in delaying aging. METHODS: Sixty male mice were randomly and equally divided into control, model, moxibustion of "Zusanli" (ST 36) and "Xuanzhong" (GB 39, M-ST 36-GB 39), moxibustion of "Baihui" (GV 20) and "Guanyuan" (CV 4,M-GV 20-COV 4) ,and medication groups. The aging model was established by subcutaneous injection of D-galactose for 42 days. Moxibustion was applied to ST 36, GB 39, GV 20 and CV 4 separately for 3 moxa-cones, once every other day for one month. The expression of cell cycle protein P 16 and retinoblastoma (pRb), and c-fos protein in the cerebral cortex tissue of the senile mice were detected by immunohistochemistry. RESULTS: Compared with control group, the number of P16 immunoreaction (IR) positive neurons in the cerebral cortex increased significantly in the model group (P<0.01), and those of cortical pRb and c-fos IR-positive neurons decreased considerably in model group (P<0.01). In comparison with the model group, the number of cortical P 16 IR-positive neurons reduced significantly in M-ST 36-GB 39, M-GV 20-CV 4 and medication groups (P<0.01), and those of cortical pRb and c-fos IR-positive neurons increased remarkably in M-ST 36-GB 39, M-GV 20-CV 4 and medication groups (P<0.01, P<0.05). No significant differences were found in the aforementioned 3 indexes among M-ST 36-GB 39, M-GV 20-CV 4 and medication groups (P>0.05). CONCLUSION: Moxibustion of ST 36-GB 39 and GV 20-CV 4 can down-regulate the P 16 expression,and up-regulate pRb and c-fos protein expression in the cerebral cortex of senile mice, which possibly contributes to its effect in delaying aging. Article Published Date : Aug 12, 2004

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