Cybermedlife - Therapeutic Actions Negative Ionization

Treatment of seasonal affective disorder with a high-output negative ionizer.

Abstract Title: Treatment of seasonal affective disorder with a high-output negative ionizer. Abstract Source: J Altern Complement Med. 1995 Jan;1(1):87-92. PMID: 9395604 Abstract Author(s): M Terman, J S Terman Abstract: This study was designed to evaluate the antidepressant effect of negative ions in the ambient air as a potential treatment modality for seasonal affective disorder. Twenty-five subjects with winter depression underwent a double-blind controlled trial of negative ions at two exposure densities, 1 x 10(4) ions/cm3 or 2.7 x 10(6) ions/cm3, using an electronic negative ion generator with wire corona emitters. Home treatments were taken in the early morning for 30 min over 20 days, followed by withdrawals. The severity of depressive symptoms (prominently including the reverse neurovegetative symptoms of hypersomnia, hyperphagia, and fatigability) decreased selectively for the group receiving high-density treatment. Standard depression rating scale assessments were corroborated by clinical impressions. When a remission criterion of 50% or greater reduction in symptom frequency/severity was used, 58% of subjects responded to high-density treatment while 15% responded to low-density treatment (chi 2 = 5.00, df = 1, p = 0.025). There were no side effects attributable to the treatment, and all subjects who responded showed subsequent relapse during withdrawal. Treatment with a high-density negative ionizer appears to act as a specific antidepressant for patients with seasonal affective disorder. The method may be useful as an alternative or supplement to light therapy and medications.   Article Published Date : Jan 01, 1995
Therapeutic Actions Negative Ionization

NCBI pubmed

Use of ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry system as valuable tool for an untargeted metabolomic profiling of Rumex tunetanus flowers and stems and contribution to the antioxidant activity.

Related Articles Use of ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry system as valuable tool for an untargeted metabolomic profiling of Rumex tunetanus flowers and stems and contribution to the antioxidant activity. J Pharm Biomed Anal. 2018 Sep 05;162:66-81 Authors: Abidi J, Ammar S, Ben Brahim S, Skalicka-Woźniak K, Ghrabi-Gammar Z, Bouaziz M Abstract Rumex tunetanus is an untapped resource with no available information about their chemical composition. That is why, the present study has conducted comprehensive metabolites profiling of the hydromethanol extracts of the Rumex tunetanus flowers and stems using RP-UHPLC-ESI-QTOF-MS. As results, 60 compounds were characterized for the first time in Rumex tunetanus between them, 18 photochemical were firstly identified in the Polygonaceae family in negative ionization mode. In this regard, quercetin-3-O-glucuronide and (-)-epicatechin gallate were the most abundant phenolic compounds in flowers and stems, respectively. Moreover, positive correlations were found between the antioxidant activity measured by DPPH and FRAP assays with the total phenolic compounds (r = 0.98; r = 0.99, respectively) and the abundance of some phenolic subfamilies such as hydroxycinnamic acids, hydroxybenzoic acids, flavonols and flavones with r > 0.86. The compounds displaying significant (P < 0.01) and good correlations with the antioxidant activity (r > 0.93) were hydroxybenzoic acid, rutin, quercetin-3-O-glucuronide, quercetin-3-O-glucoside, quercetin and luteolin-7-O-rutinoside. In conclusion, Rumex tunetanus flowers and stems showed different bioactive compound profiles and significant antioxidant properties and could be further used in food and nutraceutical industries. PMID: 30223144 [PubMed - as supplied by publisher]

Porous graphite sheet spray ionization ion mobility spectrometry.

Related Articles Porous graphite sheet spray ionization ion mobility spectrometry. J Mass Spectrom. 2018 Sep 17;: Authors: Zargar T, Jafari MT, Khayamian T Abstract In this work, a porous graphite sheet is introduced as the substrate in a spray ionization source for ion mobility spectrometry (PGSI-IMS), for the first time. This ionization source has some important advantages in comparison to the hollow needle, which is conventionally used in electrospray ionization. In order to prepare the hydrophilic surface needed to load samples on a graphite substrate, the graphite sheet was treated with hot sulfuric acid solution for 2 h. Some parameters affecting the ionization efficiency were studied and the optimized conditions were found to be 3.5 kV graphite voltage, 24 μL methanol flow rate, 500 mL min-1 the gas flow rate, and graphite sheet with a 60° tip angle and 3mm distance from the counter electrode. Finally, analyses of some test compounds (imipramine, diclofenac, codeine, morphine, and ethion) were conducted to evaluate the capability of the new ionization source in the positive and negative modes. The satisfactory results proved the capability of the graphite sheet spray ionization, to be conveniently used for routine analysis of chemical compounds by IMS. PMID: 30221428 [PubMed - as supplied by publisher]

Chemical Synthesis and Functional Analysis of VarvA Cyclotide.

Related Articles Chemical Synthesis and Functional Analysis of VarvA Cyclotide. Molecules. 2018 Apr 19;23(4): Authors: Álvarez CA, Santana PA, Luna O, Cárdenas C, Albericio F, Romero MS, Guzmán F Abstract Cyclotides are circular peptides found in various plant families. A cyclized backbone, together with multiple disulfide bonds, confers the peptides’ exceptional stability against protease digestion and thermal denaturation. In addition, the features of these antimicrobial molecules make them suitable for use in animal farming, such as aquaculture. Fmoc solid phase peptide synthesis on 2-chlorotrityl chlorine (CTC) resin using the “tea-bag” approach was conducted to generate the VarvA cyclotide identified previously from Viola arvensis. MALDI-TOF mass spectrometry determined the correct peptide amino acid sequence and the cyclization sites-critical in this multicyclic compound. The cyclotide showed antimicrobial activity against various Gram-negative bacteria, including recurrent pathogens present in Chilean aquaculture. The highest antimicrobial activity was found to be against Flavobacterium psychrophilum. In addition, membrane blebbing on the bacterial surface after exposure to the cyclotide was visualized by SEM microscopy and the Sytox Green permeabilization assay showed the ability to disrupt the bacterial membrane. We postulate that this compound can be proposed for the control of fish farming infections. PMID: 29671790 [PubMed - indexed for MEDLINE]