CYBERMED LIFE - ORGANIC  & NATURAL LIVING

Copper

  • Antimicrobial pomegranate rind extracts: enhancement by Cu(II) and vitamin C combinations against clinical isolates of Pseudomonas aeruginosa.

    Abstract Title:

    Antimicrobial pomegranate rind extracts: enhancement by Cu(II) and vitamin C combinations against clinical isolates of Pseudomonas aeruginosa.

    Abstract Source:

    Br J Biomed Sci. 2009;66(3):129-32. PMID: 19839222

    Abstract Author(s):

    S W J Gould, M D Fielder, A F Kelly, W El Sankary, D P Naughton

    Abstract:

    Recently, natural products have been further evaluated as sources of antimicrobial agents with efficacies against a variety of microorganisms. This study reports the antimicrobial activities of pomegranate rind extract (PRE) in combination with Fe(II) and Cu(II) salts against extended-spectrum multidrug-resistant Pseudomonas aeruginosa. Antimicrobial suspension assays were carried out using aqueous extract of pomegranate alone or in combination with metals salts against P. aeruginosa. The extract:metal salt combination was also enhanced with the addition of vitamin C. Marked activities were observed for the aqueous PRE/Cu(II) preparations, which were greatly enhanced by the addition of the reductant vitamin C. In contrast, the aqueous PRE/Fe(II) preparations were inactive, regardless of addition of vitamin C. The combination of PRE and Cu(II) salts and vitamin C showed the greatest activity against clinical isolates of P. aeruginosa. These results warrant further investigation of PRE as a potential source of new antimicrobial agents.

  • Apoptosis induction by Epican Forte in HTLV-1 positive and negative malignant T-cells.

    Abstract Title:

    Apoptosis induction by Epican Forte in HTLV-1 positive and negative malignant T-cells.

    Abstract Source:

    Leuk Res. 2006 Jul;30(7):869-81. Epub 2006 Jan 19. PMID: 16427125

    Abstract Author(s):

    S Harakeh, M Diab-Assaf, A Niedzwiecki, J Khalife, K Abu-El-Ardat, M Rath

    Abstract:

    The effects of a novel nutrient formulation Epican Forte (EF) were evaluated on proliferation and induction of apoptosis using non-cytotoxic concentrations against HTLV-1 positive (HuT-102&C91-PL) and negative (CEM&Jurkat) cells. EF showed anti-proliferative effect as determined by MTT assay and TGF mRNA protein expression using RT-PCR. EF resulted in the down-regulation of TGF-alpha and an up-regulation in TGF-beta2. EF caused a significant increase in apoptotic cells in the preG1 phase. These results were confirmed using Cell Death ELISA and Annexin V-FITC. Induction of apoptosis was caused by an up-regulation of p53, p21 and Bax protein levels and a down-regulation of Bcl-2alpha protein expression level.

  • Glutathione peroxidase in amyotrophic lateral sclerosis: the effects of selenium supplementation.

    Abstract Title:

    Glutathione peroxidase in amyotrophic lateral sclerosis: the effects of selenium supplementation.

    Abstract Source:

    Scand J Rheumatol. 1995;24(2):85-93. PMID: 9726810

    Abstract Author(s):

    S Apostolski, Z Marinković, A Nikolić, D Blagojević, M B Spasić, A M Michelson

    Article Affiliation:

    Institute of Neurology, School of Medicine, University of Belgrade, Yugoslavia.

    Abstract:

    The activity of glutathione peroxidase (GSH-Px) as well as the activities of other antioxidative enzymes: CuZn superoxide dismutase (CuZn SOD), catalase (CAT), glutathione reductase (GR) in erythrocytes, as well as the activity of plasma glutathione transferase (GST), and the plasma content of vitamins E and C were evaluated in 35 sporadic amyotrophic lateral sclerosis (sALS) patients. The results revealed significantly decreased activity of both GSH-Px and CuZn SOD in sALS patients compared with the control. These data showed that a disturbed oxidative/antioxidative balance in sALS patients exists not only in motoneurons but also in the blood. The effect of exogenously administered selenium (Se), antioxidants, amino acids, a Ca2+ channel blocker such as nimodipine, and their combination in Alsamin was evaluated by screening parameter levels after 9 weeks of treatment. Only the use of all components together enhanced the activity of GSH-Px and the amount of vitamin E in sALS patients. Judging by the results of clinical trials, this treatment slowed the course of the disease.

  • Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections📎

    Abstract Title:

    Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections.

    Abstract Source:

    Nutrients. 2020 Apr 23 ;12(4). Epub 2020 Apr 23. PMID: 32340216

    Abstract Author(s):

    Philip C Calder, Anitra C Carr, Adrian F Gombart, Manfred Eggersdorfer

    Article Affiliation:

    Philip C Calder

    Abstract:

    Public health practices including handwashing and vaccinations help reduce the spread and impact of infections. Nevertheless, the global burden of infection is high, and additional measures are necessary. Acute respiratory tract infections, for example, were responsible for approximately 2.38 million deaths worldwide in 2016. The role nutrition plays in supporting the immune system is well-established. A wealth of mechanistic and clinical data show that vitamins, including vitamins A, B, B, C, D, E, and folate; trace elements, including zinc, iron, selenium, magnesium, and copper; and the omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid play important and complementary roles in supporting the immune system. Inadequate intake and status of these nutrients are widespread, leading to a decrease in resistance to infections and as a consequence an increase in disease burden. Against this background the following conclusions are made: (1) supplementation with the above micronutrients and omega-3 fatty acids is a safe, effective, and low-cost strategy to help support optimal immune function; (2) supplementation above the Recommended Dietary Allowance (RDA), but within recommended upper safety limits, for specific nutrients such as vitamins C and D is warranted; and (3) public health officials are encouraged to include nutritional strategies in their recommendations to improve public health.

  • Reversing age-related eye conditions

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    <a href=There seems to be a general acceptance that we will lose sight with age, and little can be done to prevent it. Age-related far-sightedness (hyperopia) is the most common problem, with glaucoma, age-related macular degeneration and cataracts also considered part of the aging process. 

    None of that is true. There are plenty of ways to slow or halt the degeneration of the eyes with just a bit of preventive or corrective medicine. 

    Having followed my own advice, I no longer need glasses for reading. Dr Jose Mendonca, a renowned dental surgeon and jaw specialist, was diagnosed with myopia (short-sightedness) and prescribed glasses since age 11, but he now flies a plane and reads with minimal corrective lenses. He’s continued to improve since 2018.

    I suspect that all the so-called “age-related” eye problems are largely due to the lens stiffening due to deficiency in vitamin C (see box, right), which is why one of the key healers to these issues is vitamin C. 

    The business of sight requires huge amounts of energy. The job of the retina is to convert the stimulus of a photon landing on it into an electrical signal that the brain can work with. 

    The brain makes up 2 percent of our total body weight but consumes 20 percent of all the energy generated. The retina, relative to its weight, demands energy at a rate 10 times higher than the brain. No system can generate energy perfectly without some collateral damage. 

    These damaging units are free radicals. In chemical terms, free radicals have an unpaired electron. This makes them very “sticky” to other substances, and in sticking, they denature and damage those substances, causing degeneration. 

    Indeed, this is the mechanism that results in the three major eye diseases of cataract, glaucoma and macular degeneration. To mop up these free radicals we need an excellent antioxidant system.

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