CYBERMED LIFE - ORGANIC  & NATURAL LIVING

Stroke: Attenuation/Recovery

  • "Merging Yoga and Occupational Therapy (MY-OT): A feasibility and pilot study".

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    Abstract Title:

    "Merging Yoga and Occupational Therapy (MY-OT): A feasibility and pilot study".

    Abstract Source:

    Complement Ther Med. 2016 Oct ;28:44-9. Epub 2016 Aug 10. PMID: 27670869

    Abstract Author(s):

    Arlene A Schmid, Marieke Van Puymbroeck, Jennifer D Portz, Karen E Atler, Christine A Fruhauf

    Article Affiliation:

    Arlene A Schmid

    Abstract:

    OBJECTIVE:To examine the feasibility and benefits of the Merging Yoga and Occupational Therapy (MY-OT) intervention.

    DESIGN:This is the primary analysis of a non-controlled pretest-posttest pilot study to understand the feasibility and impact of MY-OT on balance, balance self-efficacy, and fall risk factor management in people with chronic stroke.

    SETTING:University research laboratory.

    PARTICIPANTS:People with chronic stroke were included in the study if they: had sustained a fall or had fear of falling, were able to stand, and hand impaired balance and were at risk for falls (≤46 on the Berg Balance Scale (BBS)).

    INTERVENTIONS:Individuals completed an 8 week intervention that included 16 sessions of both yoga and group occupational therapy (OT). Yoga included physical postures, breathing exercises, and meditation. OT focused on post-stroke fall risk factor management.

    MAIN OUTCOME MEASURES:The BBS was used to assess balance, the Activities-specific Balance Confidence Scale (ABC) was used to measure balance self-efficacy. Five fall risk factor management scales were used.

    RESULTS:Overall, the intervention was considered feasible, as individuals were able to safely complete the intervention with little attrition and high attendance. Balance improved by 30% (p=0.002). Balance self-efficacy improved by 15% (p=0.034). Each of the five fall risk factor management scales improved, but only two significantly improved (Fall Prevention and Management Questionnaire, 29%, p=0.004 and Fall Prevention Strategy Survey, 42%, p=0.032).

    CONCLUSION:The results demonstrate that MY-OT is a potential intervention to improve multiple fall related outcomes for people with stroke. Therapists may consider these interventions for people with stroke, but additional research is warranted.

  • "Merging Yoga and Occupational Therapy (MY-OT): A feasibility and pilot study".

    facebook Share on Facebook
    Abstract Title:

    "Merging Yoga and Occupational Therapy (MY-OT): A feasibility and pilot study".

    Abstract Source:

    Complement Ther Med. 2016 Oct ;28:44-9. Epub 2016 Aug 10. PMID: 27670869

    Abstract Author(s):

    Arlene A Schmid, Marieke Van Puymbroeck, Jennifer D Portz, Karen E Atler, Christine A Fruhauf

    Article Affiliation:

    Arlene A Schmid

    Abstract:

    OBJECTIVE:To examine the feasibility and benefits of the Merging Yoga and Occupational Therapy (MY-OT) intervention.

    DESIGN:This is the primary analysis of a non-controlled pretest-posttest pilot study to understand the feasibility and impact of MY-OT on balance, balance self-efficacy, and fall risk factor management in people with chronic stroke.

    SETTING:University research laboratory.

    PARTICIPANTS:People with chronic stroke were included in the study if they: had sustained a fall or had fear of falling, were able to stand, and hand impaired balance and were at risk for falls (≤46 on the Berg Balance Scale (BBS)).

    INTERVENTIONS:Individuals completed an 8 week intervention that included 16 sessions of both yoga and group occupational therapy (OT). Yoga included physical postures, breathing exercises, and meditation. OT focused on post-stroke fall risk factor management.

    MAIN OUTCOME MEASURES:The BBS was used to assess balance, the Activities-specific Balance Confidence Scale (ABC) was used to measure balance self-efficacy. Five fall risk factor management scales were used.

    RESULTS:Overall, the intervention was considered feasible, as individuals were able to safely complete the intervention with little attrition and high attendance. Balance improved by 30% (p=0.002). Balance self-efficacy improved by 15% (p=0.034). Each of the five fall risk factor management scales improved, but only two significantly improved (Fall Prevention and Management Questionnaire, 29%, p=0.004 and Fall Prevention Strategy Survey, 42%, p=0.032).

    CONCLUSION:The results demonstrate that MY-OT is a potential intervention to improve multiple fall related outcomes for people with stroke. Therapists may consider these interventions for people with stroke, but additional research is warranted.

  • A Retrospective Cohort Study Comparing Stroke Recurrence Rate in Ischemic Stroke Patients With and Without Acupuncture Treatment.

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    Abstract Title:

    A Retrospective Cohort Study Comparing Stroke Recurrence Rate in Ischemic Stroke Patients With and Without Acupuncture Treatment.

    Abstract Source:

    Medicine (Baltimore). 2015 Sep ;94(39):e1572. PMID: 26426630

    Abstract Author(s):

    Chun-Chuan Shih, Chien-Chang Liao, Mao-Feng Sun, Yi-Chang Su, Chi-Pang Wen, Donald E Morisky, Fung-Chang Sung, Chung Y Hsu, Jaung-Geng Lin

    Article Affiliation:

    Chun-Chuan Shih

    Abstract:

    Little was known about the effects of acupuncture on stroke recurrence. The aim of this study is to investigate whether ischemic stroke patients receiving acupuncture treatment have a decreased risk of stroke recurrence.A retrospective cohort study of 30,058 newly diagnosed cases of ischemic stroke in 2000 to 2004 was conducted based on the claims of Taiwan National Health Insurance Research Database. The use of acupuncture treatment and stroke recurrence were identified during the follow-up period from 2000 to 2009. This study compared the risk of stroke recurrence between ischemic stroke cohorts with and without acupuncture treatment by calculating adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of acupuncture associated with stroke recurrence in the Cox proportional hazard model.The stroke recurrence rate per 1000 person-years decreased from 71.4 without to 69.9 with acupuncture treatment (P < 0.001). Acupuncture treatment was associated with reduced risk of stroke recurrence (HR 0.88; 95% CI 0.84-0.91). The acupuncture effect was noted in patients with or without medical treatment for stroke prevention but its impact decreased with aging of stroke patients. Compared with stroke patients without acupuncture treatment and medication therapy, the hazard ratios of stroke recurrence for those had medication therapy only, acupuncture only, and both were 0.42 (95% CI 0.38-0.46), 0.50 (95% CI 0.43-0.57), and 0.39 (95% CI 0.35-0.43), respectively.This study raises the possibility that acupuncture might be effective in lowering stroke recurrence rate even in those on medications for stroke prevention. Results suggest the need of prospective sham-controlled and randomized trials to establish the efficacy of acupuncture in preventing stroke.

  • A Retrospective Cohort Study Comparing Stroke Recurrence Rate in Ischemic Stroke Patients With and Without Acupuncture Treatment📎

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    Abstract Title:

    A Retrospective Cohort Study Comparing Stroke Recurrence Rate in Ischemic Stroke Patients With and Without Acupuncture Treatment.

    Abstract Source:

    Medicine (Baltimore). 2015 Sep ;94(39):e1572. PMID: 26426630

    Abstract Author(s):

    Chun-Chuan Shih, Chien-Chang Liao, Mao-Feng Sun, Yi-Chang Su, Chi-Pang Wen, Donald E Morisky, Fung-Chang Sung, Chung Y Hsu, Jaung-Geng Lin

    Article Affiliation:

    Chun-Chuan Shih

    Abstract:

    Little was known about the effects of acupuncture on stroke recurrence. The aim of this study is to investigate whether ischemic stroke patients receiving acupuncture treatment have a decreased risk of stroke recurrence.A retrospective cohort study of 30,058 newly diagnosed cases of ischemic stroke in 2000 to 2004 was conducted based on the claims of Taiwan National Health Insurance Research Database. The use of acupuncture treatment and stroke recurrence were identified during the follow-up period from 2000 to 2009. This study compared the risk of stroke recurrence between ischemic stroke cohorts with and without acupuncture treatment by calculating adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of acupuncture associated with stroke recurrence in the Cox proportional hazard model.The stroke recurrence rate per 1000 person-years decreased from 71.4 without to 69.9 with acupuncture treatment (P < 0.001). Acupuncture treatment was associated with reduced risk of stroke recurrence (HR 0.88; 95% CI 0.84-0.91). The acupuncture effect was noted in patients with or without medical treatment for stroke prevention but its impact decreased with aging of stroke patients. Compared with stroke patients without acupuncture treatment and medication therapy, the hazard ratios of stroke recurrence for those had medication therapy only, acupuncture only, and both were 0.42 (95% CI 0.38-0.46), 0.50 (95% CI 0.43-0.57), and 0.39 (95% CI 0.35-0.43), respectively.This study raises the possibility that acupuncture might be effective in lowering stroke recurrence rate even in those on medications for stroke prevention. Results suggest the need of prospective sham-controlled and randomized trials to establish the efficacy of acupuncture in preventing stroke.

  • Acupuncture for insomnia after stroke: a systematic review and meta-analysis.

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    Abstract Title:

    Acupuncture for insomnia after stroke: a systematic review and meta-analysis.

    Abstract Source:

    BMC Complement Altern Med. 2016 ;16(1):228. Epub 2016 Jul 19. PMID: 27430619

    Abstract Author(s):

    Sook-Hyun Lee, Sung Min Lim

    Article Affiliation:

    Sook-Hyun Lee

    Abstract:

    BACKGROUND:Insomnia is the common complaint among patients with stroke. Acupuncture has increasingly been used for insomnia relief after stroke. The aim of the present study was to summarize and evaluate evidence on the effectiveness of acupuncture in relieving insomnia after stroke.

    METHODS:Seven databases were searched from inception through October 2014 without language restrictions. Randomized controlled trials (RCTs) were included if acupuncture was compared to placebo or other conventional therapy for treatment of insomnia after stroke. Assessments were performed using the Pittsburgh sleep quality index (PSQI), the insomnia severity index (ISI), the Athens insomnia scale (AIS), and the efficacy standards of Chinese medicine.

    RESULTS:A total of 165 studies were identified; 13 RCTs met our inclusion criteria. Meta-analysis showed that acupuncture appeared to be more effective than drugs for treatment of insomnia after stroke, as assessed by the PSQI (weighted mean difference, 4.31; 95 % confidence interval [CI], 1.67-6.95; P = 0.001) and by the efficacy standards of Chinese medicine (risk ratio, 1.25; 95 % CI, 1.12-1.40; P < 0.001). Intradermal acupuncture had significant effects compared with sham acupuncture, as assessed by the ISI (weighted mean difference, 4.44; 95 % CI, 2.75-6.13; P < 0.001) and the AIS (weighted mean difference, 3.64; 95 % CI, 2.28-5.00; P < 0.001).

    CONCLUSIONS:Our results suggest that acupuncture could be effective for treating insomnia after stroke. However, further studies are needed to confirm the role of acupuncture in the treatment of this disorder.

  • Acupuncture for insomnia after stroke: a systematic review and meta-analysis📎

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    Abstract Title:

    Acupuncture for insomnia after stroke: a systematic review and meta-analysis.

    Abstract Source:

    BMC Complement Altern Med. 2016 ;16(1):228. Epub 2016 Jul 19. PMID: 27430619

    Abstract Author(s):

    Sook-Hyun Lee, Sung Min Lim

    Article Affiliation:

    Sook-Hyun Lee

    Abstract:

    BACKGROUND:Insomnia is the common complaint among patients with stroke. Acupuncture has increasingly been used for insomnia relief after stroke. The aim of the present study was to summarize and evaluate evidence on the effectiveness of acupuncture in relieving insomnia after stroke.

    METHODS:Seven databases were searched from inception through October 2014 without language restrictions. Randomized controlled trials (RCTs) were included if acupuncture was compared to placebo or other conventional therapy for treatment of insomnia after stroke. Assessments were performed using the Pittsburgh sleep quality index (PSQI), the insomnia severity index (ISI), the Athens insomnia scale (AIS), and the efficacy standards of Chinese medicine.

    RESULTS:A total of 165 studies were identified; 13 RCTs met our inclusion criteria. Meta-analysis showed that acupuncture appeared to be more effective than drugs for treatment of insomnia after stroke, as assessed by the PSQI (weighted mean difference, 4.31; 95 % confidence interval [CI], 1.67-6.95; P = 0.001) and by the efficacy standards of Chinese medicine (risk ratio, 1.25; 95 % CI, 1.12-1.40; P < 0.001). Intradermal acupuncture had significant effects compared with sham acupuncture, as assessed by the ISI (weighted mean difference, 4.44; 95 % CI, 2.75-6.13; P < 0.001) and the AIS (weighted mean difference, 3.64; 95 % CI, 2.28-5.00; P < 0.001).

    CONCLUSIONS:Our results suggest that acupuncture could be effective for treating insomnia after stroke. However, further studies are needed to confirm the role of acupuncture in the treatment of this disorder.

  • Acupuncture is effective in improving functional communication in post-stroke aphasia : A systematic review and meta-analysis of randomized controlled trials.

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    Abstract Title:

    Acupuncture is effective in improving functional communication in post-stroke aphasia : A systematic review and meta-analysis of randomized controlled trials.

    Abstract Source:

    Wien Klin Wochenschr. 2019 Apr 18. Epub 2019 Apr 18. PMID: 31001680

    Abstract Author(s):

    Binlong Zhang, Yi Han, Xing Huang, Zhaolan Liu, Shuren Li, Jingling Chang, Ying Gao

    Article Affiliation:

    Binlong Zhang

    Abstract:

    OBJECTIVE:In this meta-analysis the authors evaluated the effectiveness of acupuncture in improving functional communication and language function in post-stroke aphasia (PSA) patients.

    METHODS:Data sources: MEDLINE, EMBASE, CENTRAL, AMED, SinoMed, CNKI, VIP, and Wanfang databases, ICTRP, ISRCTN, EUCTR, ClinicalTrials.gov, and Stroke Trials Registries. A search was carried out for randomized controlled trials (RCTs) investigating the effects of acupuncture compared with no treatment or placebo acupuncture on post-stroke aphasia (PSA). The searched records were independently screened by two authors, who extracted the data, and assessed risk of biasof the included RCTs. Data aggregation and risk of bias evaluation were conducted on Review Manager Version 5.3. The protocol was registered in the PROSPERO database (CRD42016037543).

    RESULTS:A total of 28 RCTs involving 1747 patients (883 patients in the treatment group and 864 patients in the control group) were included in the quantitative synthesis. The results demonstrated significant effects of acupuncture in improving PSA functional communication (P < 0.00001, standardized mean difference (SMD) = 1.01 [0.81, 1.20]), severity of impairment (P < 0.0001, SMD = 0.64 [0.45, 0.84]), spontaneous speech (P = 0.0002, SMD = 1.51 [0.71, 2.32]), auditory comprehension (P < 0.0001, SMD = 0.84 [0.43, 1.26]), repetition (P < 0.00001, SMD = 1.13 [0.75, 1.52]), naming (P = 0.03, SMD = 0.65 [0.08, 1.23]), reading (P < 0.0001, SMD = 1.56 [0.83, 2.29]), and writing (P = 0.009, SMD = 1.03 [0.25, 1.80]).

    CONCLUSION:Acupuncture seems to be effective in improving PSA functional communication and language function.

  • Acupuncture stimulation improves balance function in stroke patients: a single-blinded controlled, randomized study.

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    Abstract Title:

    Acupuncture stimulation improves balance function in stroke patients: a single-blinded controlled, randomized study.

    Abstract Source:

    Am J Chin Med. 2009;37(3):483-94. PMID: 19606509

    Abstract Author(s):

    Sen-Yung Liu, Ching-Liang Hsieh, Ta-Sen Wei, Peng-Ta Liu, Yu-Jun Chang, Tsai-Chung Li

    Abstract:

    The disturbance of balance function is one of main etiology resulting in falling down in stroke patients. A number of studies report that acupuncture may improve the motor function of stroke patients. Therefore, the aim of the present study was to investigate the effect of acupuncture on balance function. We designed a single-blinded, controlled, randomized study. A total of 30 stroke patients were randomized into experimental and control groups. Experimental groups received acupuncture treatment accompanied by the manual twisting of needles and obtaining of qi (the subjects experienced sensations of soreness, numbness, swelling and heaviness, while the acupuncturist experienced a sensation of needle resistance), whereas the control group did not receive manual twisting of needles and without obtaining of qi. All of the subjects were first-time stroke patients; infarction location was limited to either the left or right hemisphere, and all subjects were able to walk for at least 6 meters. Acupuncture stimulation (AS) was applied to Baihui (GV 20) acupoint as well as to 4 spirit acupoints (1.5 cun anterior, posterior, left and right laterals from Baihui acupoint, respectively) for 20 min. Balance function outcome measures were: (1) the displacement area of the patient's center of gravity; (2) the time taken for a patient to stand vertically from a seated position; (3) the time taken for a patient to walk a distance of 6 meters; (4) muscle strength of both lower extremities. Results indicated that the displacement area from the center of gravity decreased in the experimental group, but not in the control group. There was greater reduction in the displacement area in the experimental group than in the control group. Following AS, the time taken to reach a standing position from a seated position, as well as the time taken to walk 6 meters was decreased equally in both the experimental and control groups. The muscle strength of the hip flexor and knee extensor were increased in the paralyzed and non-paralyzed sides of patients in the experimental group, but not in the control group. The results of the present study suggest that acupuncture stimulation may induce an immediate effect that improves balance function in stroke patients.

  • Acupuncture stimulation improves balance function in stroke patients: a single-blinded controlled, randomized study.

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    Abstract Title:

    Acupuncture stimulation improves balance function in stroke patients: a single-blinded controlled, randomized study.

    Abstract Source:

    Am J Chin Med. 2009;37(3):483-94. PMID: 19606509

    Abstract Author(s):

    Sen-Yung Liu, Ching-Liang Hsieh, Ta-Sen Wei, Peng-Ta Liu, Yu-Jun Chang, Tsai-Chung Li

    Abstract:

    The disturbance of balance function is one of main etiology resulting in falling down in stroke patients. A number of studies report that acupuncture may improve the motor function of stroke patients. Therefore, the aim of the present study was to investigate the effect of acupuncture on balance function. We designed a single-blinded, controlled, randomized study. A total of 30 stroke patients were randomized into experimental and control groups. Experimental groups received acupuncture treatment accompanied by the manual twisting of needles and obtaining of qi (the subjects experienced sensations of soreness, numbness, swelling and heaviness, while the acupuncturist experienced a sensation of needle resistance), whereas the control group did not receive manual twisting of needles and without obtaining of qi. All of the subjects were first-time stroke patients; infarction location was limited to either the left or right hemisphere, and all subjects were able to walk for at least 6 meters. Acupuncture stimulation (AS) was applied to Baihui (GV 20) acupoint as well as to 4 spirit acupoints (1.5 cun anterior, posterior, left and right laterals from Baihui acupoint, respectively) for 20 min. Balance function outcome measures were: (1) the displacement area of the patient's center of gravity; (2) the time taken for a patient to stand vertically from a seated position; (3) the time taken for a patient to walk a distance of 6 meters; (4) muscle strength of both lower extremities. Results indicated that the displacement area from the center of gravity decreased in the experimental group, but not in the control group. There was greater reduction in the displacement area in the experimental group than in the control group. Following AS, the time taken to reach a standing position from a seated position, as well as the time taken to walk 6 meters was decreased equally in both the experimental and control groups. The muscle strength of the hip flexor and knee extensor were increased in the paralyzed and non-paralyzed sides of patients in the experimental group, but not in the control group. The results of the present study suggest that acupuncture stimulation may induce an immediate effect that improves balance function in stroke patients.

  • Acupuncture therapy for stroke patients.

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    Abstract Title:

    Acupuncture therapy for stroke patients.

    Abstract Source:

    Int Rev Neurobiol. 2013 ;111:159-79. PMID: 24215922

    Abstract Author(s):

    Xin Li, Qiang Wang

    Article Affiliation:

    Xin Li

    Abstract:

    Acupuncture is one of the most important parts of Traditional Chinese Medicine, has been used for more than 3000 years as prevention and treatment for various diseases in China as well as in adjacent regions, and is widely accepted in western countries in recent years. More and more clinical trials revealed that acupuncture shows positive effect in stroke, not only as a complementary and alternative medicine for poststroke rehabilitation but also as a preventive strategy which could induce cerebral ischemic tolerance, especially when combined with modern electrotherapy. Acupuncture has some unique characteristics, which include acupoint specificity and parameter-dependent effect. It also involves complicated mechanism to exert the beneficial effect on stroke. Series of clinical trials have shown that acupuncture primarily regulates the release of neurochemicals, hemorheology, cerebral microcirculation, metabolism, neuronal activity, and the function of specific brain region. Animal studies showed that the effects of acupuncture therapy on stroke were possibly via inhibition of postischemic inflammatory reaction, stimulation of neurogenesis and angiogenesis, and influence on neural plasticity. Mechanisms for its preconditioning effect include activity enhancement of antioxidant, regulation of the endocannabinoid system, and inhibition of apoptosis. Although being controversial, acupuncture is a promising preventive and treatment strategy for stroke, but further high-quality clinical trials would be needed to provide more confirmative evidence.

  • Acupuncture therapy for stroke patients.

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    Abstract Title:

    Acupuncture therapy for stroke patients.

    Abstract Source:

    Int Rev Neurobiol. 2013 ;111:159-79. PMID: 24215922

    Abstract Author(s):

    Xin Li, Qiang Wang

    Article Affiliation:

    Xin Li

    Abstract:

    Acupuncture is one of the most important parts of Traditional Chinese Medicine, has been used for more than 3000 years as prevention and treatment for various diseases in China as well as in adjacent regions, and is widely accepted in western countries in recent years. More and more clinical trials revealed that acupuncture shows positive effect in stroke, not only as a complementary and alternative medicine for poststroke rehabilitation but also as a preventive strategy which could induce cerebral ischemic tolerance, especially when combined with modern electrotherapy. Acupuncture has some unique characteristics, which include acupoint specificity and parameter-dependent effect. It also involves complicated mechanism to exert the beneficial effect on stroke. Series of clinical trials have shown that acupuncture primarily regulates the release of neurochemicals, hemorheology, cerebral microcirculation, metabolism, neuronal activity, and the function of specific brain region. Animal studies showed that the effects of acupuncture therapy on stroke were possibly via inhibition of postischemic inflammatory reaction, stimulation of neurogenesis and angiogenesis, and influence on neural plasticity. Mechanisms for its preconditioning effect include activity enhancement of antioxidant, regulation of the endocannabinoid system, and inhibition of apoptosis. Although being controversial, acupuncture is a promising preventive and treatment strategy for stroke, but further high-quality clinical trials would be needed to provide more confirmative evidence.

  • Anti-ischemic effect of curcumin in rat brain.

    Abstract Title:

    Anti-ischemic effect of curcumin in rat brain.

    Abstract Source:

    Neurochem Res. 2008 Jun;33(6):1036-43. Epub 2008 Jan 18. PMID: 18204970

    Abstract Author(s):

    Pradeep K Shukla, Vinay K Khanna, Mohd M Ali, Mohd Y Khan, Rikhab C Srimal

    Abstract:

    Turmeric has been in use since ancient times as a condiment and due to its medicinal properties. Curcumin, the yellow colouring principle in turmeric, is polyphenolic and major active constituent. Besides anti-inflammatory, thrombolytic and anticarcinogenic activities, curcumin also possesses strong antioxidant property. In view of the novel combination of properties, neuroprotective efficacy of curcumin was studied in rat middle cerebral artery occlusion (MCAO) model. Rats were subjected to 2 h of focal ischemia followed by 72 h of reperfusion. They were pre-treated with curcumin (100 mg/kg, po) for 5 days prior to MCAO and for another 3 days after MCAO. The parameters studied were behavioural, biochemical and histological. Treatment with curcumin could significantly improve neurobehavioral performance compared to untreated ischemic rats as judged by its effect on rota-rod performance and grid walking. A significant inhibition in lipid peroxidation and an increase in superoxide dismutase (SOD) activity in corpus striatum and cerebral cortex was observed following treatment with curcumin in MCAO rats as compared to MCAO group. Intracellular calcium levels were decreased following treatment with curcumin in MCAO rats. Histologically, a reduction in the infarct area from 33% to 24% was observed in MCAO rats treated with curcumin. The study demonstrates the protective efficacy of curcumin in rat MCAO model.

  • Ascorbic Acid Reduces the Adverse Effects of Delayed Administration of Tissue Plasminogen Activator in a Rat Stroke Model. 📎

    Abstract Title:

    Ascorbic Acid Reduces the Adverse Effects of Delayed Administration of Tissue Plasminogen Activator in a Rat Stroke Model.

    Abstract Source:

    Basic Clin Pharmacol Toxicol. 2015 Apr 21. Epub 2015 Apr 21. PMID: 25899606

    Abstract Author(s):

    Mohammad Allahtavakoli, Fatemeh Amin, Ali Esmaeeli-Nadimi, Ali Shamsizadeh, Mohammad Kazemi-Arababadi, Derek Kennedy

    Article Affiliation:

    Mohammad Allahtavakoli

    Abstract:

    Delayed treatment of stroke with recombinant tissue plasminogen activator (r-tPA) induces overexpression of matrix metalloproteinase 9 (MMP-9) which leads to breakdown of the blood-brain barrier (BBB) and causes more injuries to the brain parenchyma. In this study, the effect of ascorbic acid (AA), an antioxidant agent, on the delayed administration of r-tPA in a rat model of permanent middle cerebral artery occlusion (MCAO) was investigated. Forty male rats were randomly divided into four groups: untreated control rats (ischaemic animals), AA-treated (500 mg/kg; 5 hr after stroke) rats, r-tPA-treated (5 hr after stroke 1 mg/kg) rats and rats treated with the combination of AA and r-tPA. Middle cerebral artery occlusion was induced by occluding the right middle cerebral artery (MCA). Infarct size, BBB, brain oedema and the levels of MMP-9 were measured at the end of study. Neurological deficits were evaluated at 24 and 48 hr after stroke. Compared to the control or r-tPA-treated animals, AA alone (p < 0.001) or in combination with r-tPA (p < 0.05) significantly decreased infarct volume. Ascorbic acid alone or r-tPA + AA significantly reduced BBB permeability (p < 0.05), levels of MMP-9 (p < 0.05 versus control; p < 0.01 versus r-tPA) and brain oedema (p < 0.001) when compared to either the control or the r-tPA-treated animals. Latency to the removal of sticky labels from the forepaw was also significantly decreased after the administration of AA + r-tPA (p < 0.05) at 24 or 48 hr after stroke. Based on our data, acute treatment with AA may be considered as a useful candidate to reduce the side effects of delayed application of r-tPA in stroke therapy.

  • Can music therapy for patients with neurological disorders? 📎

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    Abstract Title:

    [Can music therapy for patients with neurological disorders?].

    Abstract Source:

    Tidsskr Nor Laegeforen. 2004 Dec 16 ;124(24):3229-30. PMID: 15608775

    Abstract Author(s):

    Audun Myskja

    Article Affiliation:

    Audun Myskja

    Abstract:

    Recent developments in brain research and in the field of music therapy have led to the development of music-based methods specifically aimed at relieving symptoms of Parkinson's disease and other neurologic disorders. Rhythmic auditory stimulation uses external rhythmic auditory cues from song, music or metronome to aid patients improving their walking functioning and has been shown to be effective both within sessions and as a result of training over time. Melodic intonation therapy and related vocal techniques can improve expressive dysphasia and aid rehabilitation of neurologic disorders, particularly Parkinson's disease, stroke and developmental disorders.

  • Clinical observation of acupuncture plus electroacupuncture for hand spasm in stroke patients

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    Abstract Title:

    [Clinical observation of acupuncture plus electroacupuncture for hand spasm in stroke patients].

    Abstract Source:

    Zhongguo Zhen Jiu. 2017 Sep 12 ;37(9):932-5. PMID: 29354912

    Abstract Author(s):

    Meng Tian, Tianwei Lou, Jun Leng

    Article Affiliation:

    Meng Tian

    Abstract:

    OBJECTIVE:To observe the effect difference between acupuncture combined with electroacupuncture (EA) and simple acupuncture for hand spasm in stroke patients.

    METHODS:Sixty patients were randomly assigned into an acupuncture group and a combination group, 30 cases in each one. Patients in the two groups were treated with acupuncture at the affected Jianyu (LI 15), Binao (LI 14), Jianliao (TE 14), Quchi (LI 11), Shousanli (LI 10), Waiguan (TE 5), Futu (ST 32), Liangqiu (ST 34), Xuehai (SP 10), Zusanli (ST 36), Shangjuxu (ST 37), Xiajuxu (ST 39), Yinlingquan (SP 9), Sanyinjiao (SP 6), Taixi (KI 3), Taichong (LR 3), and the points at the middle of all the dorsal muscles between metacarpal bones. EA with discontinuous wave was used in the combination group at Waiguan (TE 5) and the middle point of the dorsal muscle between the second and the third metacarpal bones. The treatment was given for 40 min, once a day for 3 courses, five treatment per week, 4 weeks as a course. The modified Ashworth scale (MAS), the Fugl-Meyer finger motor function rating scale and the modified Barthel index (BI) were observed before and after treatment in the two group.

    RESULTS:The MAS scores after treatment significantly decreased compared with those before treatment in the two groups (both<0.05), with lower score in the combination group (<0.05). The Fugl-Meyer scores and BI scores after treatment increased in the two groups (all<0.05), with higher scores in the combination group (both<0.05).

    CONCLUSION:EA combined with acupuncture can more apparently alleviate hand spasm, promote the recovery of hand function, improve the quality of life for stroke patients than simple acupuncture.

  • Clinical observation on acupuncture treatment of 150 cases of post-stroke depression according to syndrome differentiation

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    Abstract Title:

    [Clinical observation on acupuncture treatment of 150 cases of post-stroke depression according to syndrome differentiation].

    Abstract Source:

    Zhen Ci Yan Jiu. 2010 Aug;35(4):303-6. PMID: 21090335

    Abstract Author(s):

    Jia-Ping Wu

    Article Affiliation:

    Department of Acupuncture and Massage, Fangshan Hospital of Chinese Medicine, Beijing 102400, China.

    Abstract:

    OBJECTIVE:To observe the clinical therapeutic effect of acupuncture in the treatment of post-stroke depression (PSD) in the light of syndrome differentiation.

    METHODS:A total of 300 PSD patients were randomized into acupuncture group and medication group, with 150 cases in each group. For patients of acupuncture group,Sishencong (EX-HN 1), Baihui (GV 20), Shenting (GV 24), etc. were punctured combined with other acupoints according to different syndromes, once daily for 2 months. For patients of medication group, fluoxetine (20 mg/d) was administered orally,continuously for 2 months. Hamilton's depression scale (HAMD) was used to evaluate changes of PSD patients' state after the treatment.

    RESULTS:After the treatment, the scores of HAMD in both groups decreased significantly (P<0.05), and that of acupuncture group was remarkably lower than that of medication group (P<0.05). Of the two 150 PSD patients in medication and acupuncture groups, 35 (23.3%) and 16 (10.7%) cases were cured, 82 (54.7%) and 41 (27.3%) had a marked improvement, 17 (11.3%) and 57 (38.0%) had an improvement, and 16 (10.7%) and 36 (24.0%) were ineffective, with the total effective rates being 89.3% and 76.0% respectively. Chi-square test showed that the therapeutic effect of acupuncture was significantly superior to that of medication group (P<0.05).

    CONCLUSION:Acupuncture is effective in improving post-stroke depression in PSD patients.

  • Clinical observation on acupuncture treatment of 150 cases of post-stroke depression according to syndrome differentiation

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    Abstract Title:

    [Clinical observation on acupuncture treatment of 150 cases of post-stroke depression according to syndrome differentiation].

    Abstract Source:

    Zhen Ci Yan Jiu. 2010 Aug;35(4):303-6. PMID: 21090335

    Abstract Author(s):

    Jia-Ping Wu

    Article Affiliation:

    Department of Acupuncture and Massage, Fangshan Hospital of Chinese Medicine, Beijing 102400, China.

    Abstract:

    OBJECTIVE:To observe the clinical therapeutic effect of acupuncture in the treatment of post-stroke depression (PSD) in the light of syndrome differentiation.

    METHODS:A total of 300 PSD patients were randomized into acupuncture group and medication group, with 150 cases in each group. For patients of acupuncture group,Sishencong (EX-HN 1), Baihui (GV 20), Shenting (GV 24), etc. were punctured combined with other acupoints according to different syndromes, once daily for 2 months. For patients of medication group, fluoxetine (20 mg/d) was administered orally,continuously for 2 months. Hamilton's depression scale (HAMD) was used to evaluate changes of PSD patients' state after the treatment.

    RESULTS:After the treatment, the scores of HAMD in both groups decreased significantly (P<0.05), and that of acupuncture group was remarkably lower than that of medication group (P<0.05). Of the two 150 PSD patients in medication and acupuncture groups, 35 (23.3%) and 16 (10.7%) cases were cured, 82 (54.7%) and 41 (27.3%) had a marked improvement, 17 (11.3%) and 57 (38.0%) had an improvement, and 16 (10.7%) and 36 (24.0%) were ineffective, with the total effective rates being 89.3% and 76.0% respectively. Chi-square test showed that the therapeutic effect of acupuncture was significantly superior to that of medication group (P<0.05).

    CONCLUSION:Acupuncture is effective in improving post-stroke depression in PSD patients.

  • Comparison of the Effectiveness of Whole Body Vibration in Stroke Patients: A Meta-Analysis. 📎

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    Abstract Title:

    Comparison of the Effectiveness of Whole Body Vibration in Stroke Patients: A Meta-Analysis.

    Abstract Source:

    Biomed Res Int. 2018 ;2018:5083634. Epub 2018 Jan 2. PMID: 29487869

    Abstract Author(s):

    Yoo Jung Park, Sun Wook Park, Han Suk Lee

    Article Affiliation:

    Yoo Jung Park

    Abstract:

    Objectives:The goals of this study were to assess the effectiveness of WBV (whole body vibration) training through an analysis of effect sizes, identify advantages of WBV training, and suggest other effective treatment methods.

    Methods:Four databases, namely, EMBASE, PubMed, EBSCO, and Web of Science, were used to collect articles on vibration. Keywords such as"vibration"and"stroke"were used in the search for published articles. Consequently, eleven studies were selected in the second screening using meta-analyses.

    Results:The total effect size of patients with dementia in the studies was 0.25, which was small. The effect size of spasticity was the greatest at 1.24 (high), followed by metabolism at 0.99 (high), balance, muscle strength, gait, and circulation in the decreasing order of effect size.

    Conclusions:The effect sizes for muscle strength and balance and gait function, all of which play an important role in performance of daily activities, were small. In contrast, effect sizes for bone metabolism and spasticity were moderate. This suggests that WBV training may provide a safe, alternative treatment method for improving the symptoms of stroke in patients.

  • Effect of electroacupuncture in patients with post-stroke motor aphasia : Neurolinguistic and neuroimaging characteristics.

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    Abstract Title:

    Effect of electroacupuncture in patients with post-stroke motor aphasia : Neurolinguistic and neuroimaging characteristics.

    Abstract Source:

    Wien Klin Wochenschr. 2016 Sep 2. Epub 2016 Sep 2. PMID: 27590260

    Abstract Author(s):

    Jingling Chang, Hua Zhang, Zhongjian Tan, Juan Xiao, Shuren Li, Ying Gao

    Article Affiliation:

    Jingling Chang

    Abstract:

    BACKGROUND:In this study we investigated the neurolinguistic and neuroimaging characteristics of post-stroke motor aphasia patients. The effects of acupuncture on cortex activation by using magnetic resonance imaging (MRI) in patients with motor aphasia were also studied.

    METHODS:In this study 43 patients with motor aphasia after stroke were assessed according to Clinical Rehabilitation Research Center aphasia examination (CRRCAE) for linguistic evaluation and MRI and computed tomography (CT) were used for the analyses of brain lesions. The MRI imaging data were also examined using statistical parametric mapping (SPM8) software. Cortex activation images during acupuncture were analyzed using generalized linear model analysis.

    RESULTS:The results of MRI and CT showed diverse brain lesion regions of post-stroke motor aphasia including the cortex, subcortex and cortex together with the subcortex. The language-related brain areas are activated by acupuncture including frontal, temporal, parietal and occipital lobes as well as insula, precuneus and other wide range of brain function areas as shown by MRI.

    CONCLUSIONS:Our study showed that the brain lesion regions in post-stroke motor aphasia were not completely consistent with the classical motor speech center. By using MRI our study results suggest that the formation of cognitive language may be involved with the cortical-subcortical functional networks. Acupuncture may be useful for treatment of motor aphasia after stroke.

  • Effect of Tai Chi Training on Dual-Tasking Performance That Involves Stepping Down among Stroke Survivors: A Pilot Study. 📎

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    Abstract Title:

    Effect of Tai Chi Training on Dual-Tasking Performance That Involves Stepping Down among Stroke Survivors: A Pilot Study.

    Abstract Source:

    Evid Based Complement Alternat Med. 2017 ;2017:9134173. Epub 2017 Nov 15. PMID: 29270204

    Abstract Author(s):

    Wing-Nga Chan, William Wai-Nam Tsang

    Article Affiliation:

    Wing-Nga Chan

    Abstract:

    Descending stairs demands attention and neuromuscular control, especially with dual-tasking. Studies have demonstrated that stroke often degrades a survivor's ability to descend stairs. Tai Chi has been shown to improve dual-tasking performance of healthy older adults, but no such study has been conducted in stroke survivors. This study investigated the effect of Tai Chi training on dual-tasking performance that involved stepping down and compared it with that of conventional exercise among stroke survivors. Subjects were randomized into Tai Chi (= 9), conventional exercise (= 8), and control (= 9) groups. Those in the former two groups received 12-week training. Assessments included auditory Stroop test, stepping down test, and dual-tasking test involving both simultaneously. They were evaluated before training (time-1), after training (time-2), and one month after training (time-3). Tai Chi group showed significant improvement in the auditory Stroop test from time-1 to time-3 and the performance was significantly better than that of the conventional exercise group in time-3. No significant effect was found in the stepping down task or dual-tasking in the control group. These results suggest a beneficial effect of Tai Chi training on cognition among stroke survivors without compromising physical task performance in dual-tasking. The effect was better than the conventional exercise group. Nevertheless, further research with a larger sample is warranted.

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