Micotherapy

is a white-rot fungus that has been viewed as a traditional Chinese tonic for promoting health and longevity. It has been revealed that several extractions from, such as Ethanol extract, aqueous extract, mycelia extract, water soluble extract of the culture medium ofmycelia, Ganodermasides A, B, C, D, and some bioactive components of, including Reishi Polysaccharide Fraction 3,polysaccharides I, II, III, IV,peptide,polysaccharide peptide, totaltriterpenes and Ganoderic acid C1 could exert lifespan elongation or related activities. Although the use ofas an elixir has been around for thousands of years, studies revealing its effect of lifespan extension are only the tip of the iceberg. Besides which, the kinds of extractions or components being comfrimed to be anti-aging are too few compared with the large amounts ofextractions or constituients being discovered. This review aims to lay the ground for fully elucidating the potential mechanisms ofunderlying anti-aging effect and its clinical application.