Prescription consisting of Vitamin C and Baicalin inhibits tumor growth by enhancing the antioxidant capacity in vivo.
J BUON. 2015 Sep-Oct;20(5):1368-72. PMID: 26537087
Kun Li
PURPOSE: To explore the antitumor effect of prescription consisting of Vitamin C (Vc) and Baicalin (PVB).
METHODS: To explore the antitumor effect of PVB, using U14 cervical tumor-bearing mice model was used and the drugs were administrated through the gavages. Spectrophotometry was used to determine the content of superoxide dismutase (SOD), malondialdehyde (MDA) and cytokines IL-2, Il-4 and IFN-γ.
RESULTS: PVB had a better antitumor effect than baicalin and Vc used alone with an inhibition rate of 58.18% (p<0.05); PVB significantly improved the spleen index (p<0.01), and significantly reduced MDA content (p<0.01) but increased SOD activity in liver tissue and serum (p<0.01).
CONCLUSIONS: PVB shows better antitumor effect than Vc and baicalin used alone, and it can significantly enhance the immunity and antioxidant capacity of the mice.
